Current use and development of fish vaccines in China

Wang, Qingchao; Ji, Wei; Xu, Zhen

doi:10.1016/j.fsi.2019.12.010

Cited by 91 publications

(57 citation statements)

References 127 publications

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“…Chemotherapy by antibiotics against infections caused by bacterial pathogens antibiotics against infections caused by bacterial pathogens leads to the emergence and spread of antibiotic resistance. Although several vaccines have been approved by the national veterinary drug certificate agency in China, these products have not been achieved real industrialized use due to a number of limits [6]. Thus, alternative strategies are urgently needed for combating resistant A. hydrophila.…”

Section: Introductionmentioning

confidence: 99%

Thymol Protects Channel Catfish from Aeromonas hydrophila Infection by Inhibiting Aerolysin Expression and Biofilm Formation

et al. 2020

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Aeromonas hydrophila is an opportunistic pathogen responsible for a number of diseases in freshwater farming. Moreover, the bacterium has been identified as a zoonotic pathogen that threatens human health. Antibiotics are widely used for treatments of infectious diseases in aquaculture. However, the abuse of antibiotics has led to the emergence of antimicrobial resistant strains. Thus, novel strategies are required against resistant A. hydrophila strains. The quorum sensing (QS) system, involved in virulence factor production and biofilm formation, is a promising target in identifying novel drugs against A. hydrophila infections. In this study, we found that thymol, at sub-inhibitory concentrations, could significantly reduce the production of aerolysin and biofilm formation by inhibiting the transcription of genes aerA, ahyI, and ahyR. These results indicate that thymol inhibits the quorum sensing system. The protective effects of thymol against A. hydrophila mediated cell injury were determined by live/dead assay and lactate dehydrogenase (LDH) release assay. Moreover, the in vivo study showed that thymol could significantly decrease the mortality of channel catfish infected with A. hydrophila. Taken together, these findings demonstrate that thymol could be chosen as a phytotherapeutic candidate for inhibiting quorum sensing system-mediated aerolysin production and biofilm formation in A. hydrophila.

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Section: Introductionmentioning

confidence: 99%

Thymol Protects Channel Catfish from Aeromonas hydrophila Infection by Inhibiting Aerolysin Expression and Biofilm Formation

et al. 2020

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“…been the largest producer and consumer of aquaculture in the world, counting for approximately 60% of the global productions [31]. However, the expansion of breeding scale results in the emergence of fish diseases and other problems [32]. Among of which, bacterial infections have become the main obstruction to freshwater farming [33].…”

Section: Discussionmentioning

confidence: 99%

Luteolin decreases the pathogenicity of Aeromonas hydrophila via inhibiting the activity of aerolysin

et al. 2020

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“…These shrimp and fish diseases cause severe economic losses and consequently preclude the sustainability of this industry [3,5]. Vaccination is an effective measure to deal with V. alginolyticus infection [6,7], which belongs to the low-cost and "green" approaches against bacterial pathogens [8]. Despite the advantages of vaccination, the approach is not applicable to small fish that are frequently raised in developing countries like China.…”

Section: Introductionmentioning

confidence: 99%

Malate enhances survival of zebrafish against Vibrio alginolyticus infection in the same manner as taurine

Yang

et al. 2020

Virulence

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Development of low-cost and eco-friendly approaches to fight bacterial pathogens is especially needed in aquaculture. We previously showed that exogenous malate reprograms zebrafish's metabolome to potentiate zebrafish survival against Vibrio alginolyticus infection. However, the underlying mechanism is unknown. Here, we use GC-MS based metabolomics to identify the malate-triggered metabolic shift. An activated TCA cycle and elevated taurine are identified as the key metabolic pathways and the most crucial biomarker of the reprogrammed metabolome, respectively. Taurine elevation is attributed to the activated TCA cycle, which is further supported by the increased expression of genes in the metabolic pathway of taurine biosynthesis from the isocitrate of the TCA cycle to taurine. Exogenous taurine increases the survival of zebrafish against V. alginolyticus infection as malate did. Moreover, exogenous taurine and malate regulate the expression of innate immunity genes and promote the generation of reactive oxygen species and nitrogen oxide in a similar way. The two metabolites can alleviate the excessive immune response to bacterial challenge, which protects fish from bacterial infection. These results indicate that malate enhances the survival of zebrafish to V. alginolyticus infection via taurine. Thus, our study highlights a metabolic approach to enhance a host's ability to fight bacterial infection.

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Current use and development of fish vaccines in China

Cited by 91 publications

References 127 publications

Thymol Protects Channel Catfish from Aeromonas hydrophila Infection by Inhibiting Aerolysin Expression and Biofilm Formation

Thymol Protects Channel Catfish from Aeromonas hydrophila Infection by Inhibiting Aerolysin Expression and Biofilm Formation

Luteolin decreases the pathogenicity of Aeromonas hydrophila via inhibiting the activity of aerolysin

Malate enhances survival of zebrafish against Vibrio alginolyticus infection in the same manner as taurine

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