“…Further elucidation of the latter and how it is modulated by viruses thus presents as important aspect of focus. After cholesterol-dependent steps in endocytosis, shuttling of the lipid within virus-containing endosomes further is important for the uncoating, and therefore for final cellular entry, of enveloped viruses, such as members of the Filoviridae family, IAV, HIV, SARS-CoV-2, and Alphaviruses ( Schroeder, 2010 ; Carette et al, 2011 ; Côté et al, 2011 ; Garcia-Dorival et al, 2020 ; Martyna et al, 2020 ; Sousa et al, 2020 ). This process is reported to be mediated via cholesterol-shuttling proteins, such as NPC1.…”