Current understanding of the intratumoral microbiome in various tumors

Xue, Chen; Chu, Qingfei; Zheng, Qiuxian; Su, Yuanshuai; Bao, Zhengyi; Lu, Juan; Li, Lanjuan

doi:10.1016/j.xcrm.2022.100884

Cited by 33 publications

(31 citation statements)

References 121 publications

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“…The enrichment of the metabolic pathways of differential metabolites indicates significant upregulation of the tryptophan (Trp) metabolic pathway, which is involved in the regulation of various physiological processes, including inflammation, immune responses, and neurological functions (Figure S12c,d, Supporting Information). [35] In the Trp metabolic pathway, the significant upregulation of Nacetylserotonin (NAS) with neuroprotective properties superior to melatonin as an antioxidant evidences that the Au@BT + US treatment can exert neuroprotective effects by inhibiting oxidative stress. [36] The above results inspire us that such Au@BT + US treatment can function as a potential neuroprotective agent not only through the free radical scavenging effect of H 2 but also by regulating the tryptophan metabolic pathway for further protection.…”

Section: The Therapeutic Mechanism Of H 2 Generated Through Piezoelec...mentioning

confidence: 99%

In Situ Piezoelectric‐Catalytic Anti‐Inflammation Promotes the Rehabilitation of Acute Spinal Cord Injury in Synergy

You,

Jiang,

Zheng

et al. 2024

Advanced Materials

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Relieving inflammation via scavenging toxic reactive oxygen species (ROS) during the acute phase of spinal cord injury (SCI) has been proved to be an effective strategy to mitigate secondary spinal cord injury and improve recovery of motor function. However, commonly used corticosteroid anti‐inflammatory drugs such as methylprednisolone show adverse side effects which may induce gastrointestinal bleeding, femoral head necrosis and an increased risk of wound infection. Fortunately, hydrogen (H2), featuring selective antioxidant performance, easy penetrability and excellent biosafety, is being extensively investigated as a potential anti‐inflammatory therapeutic gas for the treatment of SCI. In this work, by a facile in situ growth approach of gold nanoparticles (AuNPs) on the piezoelectric BaTiO3, a particulate nanocomposite with Schottky heterojunction (Au@BT) has been synthesized, which can generate H2 continuously by catalyzing H+ reduction through piezoelectric catalysis. Furthermore, theoretical calculations were employed to reveal the piezoelectric catalytic mechanism of Au@BT. Transcriptomics analysis and nontargeted large‐scale metabolomic analysis reveal that the deeper mechanism of the neuroprotective effect of H2 therapy based on Au@BT + US. The as‐prepared Au@BT nanoparticles have been first explored as a flexible hydrogen gas generator for efficient anti‐inflammatory and pro‐repair application for SCI therapy. This study highlights a promising prospect of nanocatalytic medicine for disease treatments by catalyzing H2 production, thus offering a significant alternative to conventional approaches against refractory spinal cord injury.This article is protected by copyright. All rights reserved

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Section: The Therapeutic Mechanism Of H 2 Generated Through Piezoelec...mentioning

confidence: 99%

In Situ Piezoelectric‐Catalytic Anti‐Inflammation Promotes the Rehabilitation of Acute Spinal Cord Injury in Synergy

You,

Jiang,

Zheng

et al. 2024

Advanced Materials

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“…In overall, a complex conjunction of the microbial abundances and presence of specific pathogenic species in the tumour microenvironment determine the fate of the disease progression. A compilation of studies characterising the microbiome, its function and implications across various tumour types including the HNSCC has been provided in a review 55 . Another recent review provides an exhaustive compilation the clinical studies investigating HNSCC associated microbes, their tumour stage specific presence and their relation to prognostic outcomes 56 .…”

Section: Microbes Associated With Head and Neck Squamous Cell Carcinomamentioning

confidence: 99%

Influence of pathogens on host genome and epigenome in development of head and neck cancer

Desai

2023

Cancer Reports

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BackgroundHead and neck cancer (HNSCC) is a heterogeneous group of cancers, affecting multiple regions such as oral cavity, pharynx, larynx, and nasal region, each showing a distinct molecular profile. HNSCC accounts for more than 6 million cases worldwide, soaring mainly in the developing countries.Recent findingsThe aetiology of HNSCC is complex and multifactorial, involving both genetic and environmental factors. The critical role of microbiome, which includes bacteria, viruses, and fungi, is under spotlight due to the recent reports on their contribution in the development and progression of HNSCC. This review focuses on the effect of opportunistic pathogens on the host genome and epigenome, which contributes to the disease progression. Drawing parallels from the host‐pathogen interactions observed in other tumour types arising from the epithelial tissue such as colorectal cancer, the review also calls attention to the potential explorations of the role of pathogens in HNSCC biology and discusses the clinical implications of microbiome research in detection and treatment of HNSCC.ConclusionOur understanding of the genomic effects of the microbes on the disease progression and the mechanistic insights of the host‐pathogen interaction will pave way to novel treatment and preventive approaches in HNSCC.

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“…Despite rapid technological advances, cancer, as the secondleading cause of death worldwide, remains one of the greatest threats to human life. [1][2][3] Although much effort has been taken to treat cancer, chemotherapy and radiotherapy remain the dominant therapeutic methods, with several negative and serious side effects. [4][5][6][7] In recent years, phototherapy, including photodynamic therapy (PDT) and photothermal therapy (PTT), 8 has been developed as an innovative approach for cancer treatment and has attracted considerable attention for being less invasive, more selective, and having fewer side effects compared to traditional cancer protocols.…”

Section: Introductionmentioning

confidence: 99%