Current Understanding of Antitumor Immunity

Жановна, Шубина Ирина; Сергеев, А. В.; Мамедова, Л. Т.; Соколов, Н. Ю.; Киселевский, М В

doi:10.17650/1726-9784-2015-14-3-19-28

Cited by 3 publications

(2 citation statements)

References 51 publications

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“…Стойкое снижение функциональной активности CD4 +и CD8 + -клеток у ВИЧ-инфицированных пациентов обеспечивает ускользание опухолевых клеток из-под иммунного ответа [40]. Среди основных факторов формирования противоопухолевого иммунного ответа можно условно выделить эффективное функционирование антиген-презентирующих клеток (АПК), NK-клеток [натуральные (естественные) киллеры, Natural killer cells], CD4 + -и CD8 + -лимфоцитов, а также синтез специфических антител, способствующих реализации эффекторных механизмов как врожденного, так и приобретенного иммунитета [41].…”

Section: развитие диффузной в-крупноклеточной лимфомы на фоне инфицир...unclassified

Pathogenetic properties of HIV-related diffuse large B-cell lymphoma

Chernysheva,

Gadzhikulieva,

Tsyganova

2023

Infectious diseases: News, Opinions, Training

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АНАЛИТИЧЕСКИЕ ОБЗОРЫ Патогенетические аспекты развития диффузной В-крупноклеточной лимфомы при ВИЧ-инфекции 1 Федеральное государственное бюджетное научное учреждение «Научноисследовательский институт нормальной физиологии имени П.К. Анохина», 125315, г. Москва, Российская Федерация 2 Федеральное государственное бюджетное образовательное учреждение высшего образования «Московский государственный медико-стоматологический университет имени А.И. Евдокимова» Министерства здравоохранения Российской Федерации, 127473, г. Москва, Российская Федерация 3 Московский городской центр профилактики и борьбы со СПИДом Департамента здравоохранения г. Москвы, 105275, г. Москва, Российская Федерация

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Section: развитие диффузной в-крупноклеточной лимфомы на фоне инфицир...unclassified

Pathogenetic properties of HIV-related diffuse large B-cell lymphoma

Chernysheva,

Gadzhikulieva,

Tsyganova

2023

Infectious diseases: News, Opinions, Training

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“…Активное взаимодействие раковых и иммунокомпетентных клеток представляет комплекс молекулярноклеточных событий в ходе воспалительной реакции. Воспалительный опухолевый инфильтрат представлен клетками врожденного и адаптивного иммунного ответа: гранулоцитами, макрофагами, дендритными клетками, NK-, Т-, NKT-лимфоцитами [19,20] Диагностика и лечение опухолей мочеполовой системы. Рак мочевого пузыря как это свойственно норме.…”

Section: роль микроокружения в развитии злокачественных новообразованийunclassified

Study of association between molecular marker expression on tumor and immunocompetent cells and sensitivity to adjuvant and neoadjuvant therapy of bladder cancer

et al. 2019

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Use of immunotherapy in treatment of muscle-invasive bladder cancer remains the most promising method in case of impossibility of chemotherapy with cisplatin or progression during cisplatin treatment. This approach is the method of choice and can prolong patient’s life. In particular, use of checkpoint inhibitors allows to obtain effective treatment of bladder cancer. However, to prescribe immunotherapeutic medication, patient must have point of application for these drugs. Individualized approach will allow to increase treatment effectiveness and disease prognosis while maximally improving the quality of life.

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Assessment of cellular and humoral immunity in sentinel lymph node in breast cancer

Neryakhin

Gallyamov

Kamilianov

et al. 2022

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Introduction The morphofunctional status of the sentinel lymph node (SLN) is a prognostic factor of tumor metastasis. According to the modern concept, lymphagenic metastasis of the tumor is highest in the SLN, and in the absence of metastases in it, the probability of the absence of metastases in other lymph nodes is high. In the era of the development of new immune treatments for breast cancer, the identification of biomarkers that can predict the status of lymph nodes becomes an important task.The aim is immunohistochemical study of the expression level of T- and B-lymphocyte markers in breast cancer in the absence and presence of metastases in them.Materials and methods Sentinel lymph nodes without metastases and with metastases obtained during breast cancer surgery in 18 patients were studied using the immunohistochemical method.Results Comparative morphological analysis revealed that the number of CD3- and CD20-immunopositive cells was significantly higher in the SLN without metastases.Discussions The humoral and cellular immune systems take part in the antitumor immune response. Control over the growth of the tumor is carried out mainly by T cells. The results of our study showed a relatively high level of them in the SLN without metastatic lesion. The information about the antitumor activity of B-lymphocytes is contradictory since both the positive and negative role of B-cells in anticancer immunity is shown. The results of the studies showed that in the case of secondary foci of tumor growth, the number of CD20+ B cells is significantly lower, which indicates the important role of humoral immunity in addition to cell-mediated immunity in breast cancer.Conclusion Quantitative evaluation of (CD3+CD20) cells in the SLN can be used as a possible prognostic marker for breast tumor metastasis.

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Current Understanding of Antitumor Immunity

Cited by 3 publications

References 51 publications

Pathogenetic properties of HIV-related diffuse large B-cell lymphoma

Pathogenetic properties of HIV-related diffuse large B-cell lymphoma

Study of association between molecular marker expression on tumor and immunocompetent cells and sensitivity to adjuvant and neoadjuvant therapy of bladder cancer

Assessment of cellular and humoral immunity in sentinel lymph node in breast cancer

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