Current Trends of Plants Having Antidiabetic Activity: A Review

Kayarohanam, Saminathan

doi:10.4172/1948-593x.1000124

Cited by 39 publications

(28 citation statements)

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“…whereas herbal medicine is considered as less toxic than synthetic medicine 5 . According to the ethnobotanical information, approximately 800 plants have antidiabetic activity 6 . Musa balbisina commonly found in our country belongs to the Musaceae family and cultivated in Eastern South Asia, Northern Southeast Asia, and Southern China.…”

Section: Introductionmentioning

confidence: 99%

Untitled

2019

IJPSR

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Background: Musa balbisiana Colla (Musaceae family) is used as folkloric medicine throughout India. Objective: To search out the potent dose of a hydro-methanolic extract of Musa balbisiana flower for antidiabetic and antioxidative activities in streptozotocin-induced diabetic rat. Material and Methods: The extract of the said plant part was administered orally at the dose of 5, 10 or 20 mg /100 g body weight for 28 days. Diabetes was induced by a single intramuscular injection of streptozotocin at the dose of 4 mg / 0.1 ml of citrate buffer / 100 g body weight to Wistar stain albino male rat. Biochemical, histological and thin layer chromatographic profiles were studied. Results: Treatment with 10 mg or 20 mg doses exhibited a significant recovery from diabetes by decreasing fasting blood glucose and glycated hemoglobin levels along with increasing the serum insulin level. Significant recovery was noted in antioxidative and carbohydrate metabolic enzymes' activities in hepatic and skeletomuscular tissues in diabetic rat. The extract had no metabolic toxicity. From the qualitative phytochemical analysis of said extract, the presence of flavonoids, alkaloids, phenols, and triterpenes was noted. Discussion and Conclusion: Results indicated that 10 mg dose was considered as a minimum but effective dose. The higher dose was not more effective probably due to the saturation of the receptors of the concerned phytomolecules present in the extract, and therefore the remedial effect was not improved by higher doses. So, it may be concluded that 10 mg is the potent dose for the correction of diabetes as well as diabetes-induced oxidative stress.

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Section: Introductionmentioning

confidence: 99%

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2019

IJPSR

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“…Through in vivo studies using animal models, a number of plants with anti-diabetic activity have been discovered (Bnouham et al, 2006;Kayarohanam et al, 2015;Mussie et al, 2015;Tsabang et al, 2017), but there is paucity of studies on V. major in relation to diabetic activity and other biochemical parameters. The present study investigated the effect of ethanolic leaf extract of Vinca major L. on biochemical parameters and glucose level of alloxan induced diabetic rats.…”

Section: Introductionmentioning

confidence: 99%

Effect of ethanolic leaf extract of Vinca major L. on biochemical parameters and glucose level of alloxan induced diabetic rats

Comfort¹,

Majesty²,

Adindu³

et al. 2019

Afr. J. Biotechnol.

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In view of World Health Organization (WHO) recommendation on the use of medicinal plants for the management of diabetes mellitus, this study evaluated the effect of ethanolic leaf extract of Vinca major L. on biochemical parameters and glucose level of alloxan induced diabetic rats as objective. Sixty-four male Wistar albino rats were induced with diabetes by a single intraperitoneal injection and were separated into four groups (1-4) of sixteen rats each. Group 1 served as the control while groups 2 to 4 served as the test groups. Apart from the control, the test groups were treated with different concentrations of the leaf extract, and four rats from each group were sacrificed every seven days for assessment. The treatment period lasted for 28 days. Haemoglobin (Hb) levels in groups 3 and 4 rats significantly increased (p<0.05) against the control throughout the number of days of the study. Red blood cell (RBC) levels in groups 2 and 4 increased significantly (p<0.05) against the control on the 14 th day, while all the test group rats had significantly increased (p<0.05) RBC levels on the 21 st and 28 th days of the study. The observed trend followed by electrolyte ions, urea and creatinine in test rats against the control in the present study, may be attributed to V. major leaf extract trying to salvage the excretory organs of alloxan battered diabetic rats. Glucose level, aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) liver enzymes reduced significantly (p<0.05) in test rats against the control. Diabetic rats treated with V. major leaf extract in this study, showed significant improvements on those associate problems of diabetes which include anaemia, dyslipidaemia, and hepatic necrosis and inflammation. Rats treated with the leaf extract also showed reduced glucose level (Hypoglycemia). From the observations of this study, extract from leaf of V. major may be effective against diabetes and some of its associate problems.

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“…Diabetes Mellitus (DM) is one of the most prevalent metabolic disorders characterized by increased blood glucose level and improper primary metabolism resulting from the defects in insulin secretion, insulin action, or both. It is one of the most common health problem worldwide, and the prevalence of this disease is rapidly increasing, leading to microvascular (retinopathy, neuropathy and nephropathy) and macrovascular (heart attack, stroke and peripheral vascular disease) complication 13,14 . Reactive oxygen species (ROS) produced during hyperglycemia, which plays a major role in complications of diabetes.…”

Section: Introductionmentioning

confidence: 99%

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2018

IJPSR

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The Pharmacological effects of silver nanoparaticle of Stemodia viscosa aqueous plant extract on albino wistar rats was explored. The plant extract 40 ml was added to 10 ml of 10mM silver nitrate aqueous solution and kept at room temperature for synthesizing silver nanoparaticle. Diabetes was induced in overnight fasted mice by single intra-peritoneal injection of 55 mg/kg of Streptozotozin (STZ), freshly dissolved in 0.1M cold citrate buffer, pH 4.5. After five days of STZ administration, blood was collected and plasma glucose levels were determined. For wound healing activity, a control ointment base was formulated without any drug content. Two creams were formulated by using 5% extract were incorporated in 100gm of cream base. The observation of the percentage wound contraction were made on 4 th , 8 th , 12 th , 16 th and 22 nd day of post wounding days. All the values were statistically analyzed by unpaired student test comparing with control. The administrations of plant extract to STZ induce diabetic mice, significantly lowered the plasma glucose level as compared to diabetic control. The study is further, extended to analyze lipid profile which was significant that Streptozotocin induced mice was found to be higher with 67.05 mg/dl than the normal control mice. The ointment formation were prepared from the plant extract the results given in that wound contracting ability of Stemodia viscosa ointment (5% w/w) was found significant than the control. Stemodia viscosa exhibit a remarkable wound healing and anti-lipedmic activity.

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Current Trends of Plants Having Antidiabetic Activity: A Review

Cited by 39 publications

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Effect of ethanolic leaf extract of Vinca major L. on biochemical parameters and glucose level of alloxan induced diabetic rats

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