Current trends of benzothiazoles in drug discovery: a patent review (2015–2020)

Multifunctional Catalysis of Nanosheet Defective Molybdenum Sulfide Basal Planes for Tandem Reactions Involving Alcohols and Molecular Hydrogen

“…In situ infrared spectroscopy studies confirm the vital role of the multifunctional character of the catalyst {Mo 3 S 4 } n , containing both Lewis acid and Lewis basic sites distributed along the basal planes, for the reaction to be successfully accomplished. In addition, in view of this uncommon catalytic behavior, we also generalize the applicability of the catalyst {Mo 3 S 4 } n to prepare other valuable benzene-fused heterocycles, such as 2-arylbenzothiazoles, − via this rare straightforward coupling reaction strategy combining alcohols, molecular hydrogen, and, in this particular case, 2,2′-dinitrodiphenyl disulfide.…”

A β-ketoenamine-linked covalent organic framework as a heterogeneous photocatalyst for the synthesis of 2-arylbenzothiazoles by cyclization reaction

“…Benzothiazole along with its derivatives are widely found in nature, and used in drugs and materials as a valuable organic molecular skeleton. [1][2][3][4][5][6][7][8] In particular, 2-arylbenzothiazole and its derivatives have excellent physiological and pharmacological value as the basic structural and functional units of various drug intermediates 9 which are widely used in antitumor drugs, 10,11 antibacterial agents, 12,13 antiproliferative agents and anti-inflammatory drugs (Fig. 1).…”

Synthesis of 2-Cyanobenzothiazoles via Pd-Catalyzed/Cu-Assisted C-H Functionalization/Intramolecular C-S Bond Formation from N-Arylcyanothioformamides

“…Benzothiazole is a heterocyclic system originally discovered in marine natural molecules and also present in terrestrial specimens. Its numerous applications in therapeutics are regularly patented and published in comprehensive reviews describing their role against metabolic, inflammatory, neurodegenerative, viral and bacterial diseases [ 1 , 2 , 3 , 4 , 5 , 6 ]. In recent years, researchers have focused their efforts on the anti-cancer potential of benzothiazoles or their derivatives [ 7 , 8 , 9 , 10 , 11 , 12 , 13 ].…”

“…All these studies have shown that the biological activities of benzothiazoles are highly dependent on the nature and position of their substituents. The most favorable positions are carbon C2, C5 and C6 of the benzothiazole skeleton, and the number of functional groups can vary from 1 to 3 and range from a simple chemical function to more complex aliphatic or heterocyclic systems [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 ]. It is important to note that the benzothiazoles showing significant biological activity are mainly substituted at the C2 position of the thiazole ring.…”