Current Trends in the Development of Wound dressings, Biomaterials and Devices

Abstract

Wound management covers all aspects of patient care from initial injury, treatment of infection, fluid loss, tissue regeneration, wound closure to final scar formation and remodeling. There are many wound-care products available including simple protective layers, hydrogels, metal ion-impregnated dressings and artificial skin substitutes, which facilitate surface closure. This review examines recent developments in wound dressings, biomaterials and devices. Particular attention is focused on the design and manufacture of hydrogel-based dressings, their polymeric constituents and chemical modification. Finally, topical negative pressure and hyperbaric oxygen therapy are considered. Current wound-management strategies can be expensive, time consuming and labor intensive. Progress in the multidisciplinary arena of wound care will address these issues and be of immense benefit to patients, by improving both clinical outcomes and their quality of life.

Evaluation of genipin-crosslinked chitosan hydrogels as a potential carrier for silver sulfadiazine nanocrystals

“…Several reviews had summarized and analyzed the merits of polymer hydrogels applied for wound care [18][19][20][21]. In our previous work CHI hydrogels were prepared by using natural genipin as crosslinking agent.…”

Evaluation of a bilayered, micropatterned hydrogel dressing for full-thickness wound healing

“…45 Despite many advances in our understanding of wound healing, [45][46][47][48][49] the treatment of full-thickness wounds has focused primarily on regenerating dermis, 50,51 while neglecting or even impeding re-epithelialization of the epidermal layer. No clinically available dressings have all of the characteristics required to repair the dermis and epidermis concurrently.…”

Effectiveness of Modern Wound Dressing on the Growth of Staphylococcus Aureus Bacteria

“…Modern wound dressing yang telah dikembangkan terbuat dari polimer sintetis dan diklasifikasikan sebagai produk pasif, interaktif dan bioaktif (Dhivya et al, 2015), dalam bentuk hidrokoloid, alginat, hidrogel, film, dan busa (Borda, Macquhae, & Kirsner, 2016). Modern wound dressing yang mengandung antimikroba telah dikembangkan sejak dua puluh tahun terakhir, efektif membunuh bakteri dan jamur pada luka, mencegah infeksi berulang selama penyembuhan (Boateng & Catanzano, 2015), dan efektif untuk pengobatan luka yang terinfeksi (Martin et al, 2013). Meningkatnya pertumbuhan bakteri Staphylococcus Aureus akan menghambat proses penyembuhan luka yang terinfeksi (Shahzad et al, 2015 …”

“…Namun, modern wound dressing berjenis hidrogel memiliki beberapa polimer yang telah dikembangkan dalam beberapa tahun terakhir untuk diaplikasikan dalam perawatan luka (Martin et al, 2013). polimer alam dan sintetis yang banyak digunakan dalam perawatan luka akut dan kronis karena memiliki aktivitas antimikroba (Sarheed et al, 2016).…”

“…Selain itu, Alginat juga digunakan untuk luka yang dalam (Dissemond et al, 2014). Oleh sebab itu, alginat mampu membuktikan pembentukan jaringan atau granulasi dan re-epitelisasi lebuh cepat (Martin et al, 2013). alginat dengan komposisi pektin yang mengandung gentamicine sulfat mampu merangsang cytokine, diproduksi oleh monosit manusia yang sangat berguna untuk mempercepat penyembuhan luka dalam (De Cicco, Reverchon, et al, 2014;De Cicco, Porta, Sansone, Aquino, & Del Gaudio, 2014).…”