Current trends in the analytical determination of vitamin D

Vázquez-Lorente, Héctor; Herrera-Quintana, Lourdes; Quintero-Osso, Bartolomé; Molina-López, Jorge; Planells, Elena

doi:10.20960/nh.02713

Cited by 4 publications

(2 citation statements)

References 27 publications

(15 reference statements)

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“…Also, several physical factors, including clothing, sunscreen, residential location and shielding provided by buildings, may influence the amount of absorbable 25(OH)D. Despite the introduction of schemes/programmes to improve the accuracy of assays to measure 25(OH)D, significant differences might still happen. Although LC-MS/MS has emerged as a gold standard for reliable, accurate and high-throughput quantification of vitamin D metabolites, and the Elecsys concentrations recorded by Modular E analyser were in good overall agreement with those determined with LC-MS/MS (48,49) , it is necessary to harmonise the methodologies so they can be decisive in assessing a large number of subjects (49). Therefore, differences in these factors could result in the outcomes being not generalisable to other populations.…”

Section: Strengths and Limitations Of The Present Studymentioning

confidence: 81%

Association between serum vitamin D and depressive symptoms in apparently healthy male adults undergoing routine health check-ups at a single centre

Kim

Lee

Chae

et al. 2020

Public Health Nutr.

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Objective: To determine the level of vitamin D and to identify the association between vitamin D and depressive symptoms in apparently healthy Korean male adults. Design: A retrospective study design. Among 43 513 participants between 1 March and 30 November 2018, after eliminating participants with a history of depression or vitamin D deficiency, 9058 were included. To determine the level of vitamin D, serum 25-hydroxyvitamin D [25(OH)D] was measured. To assess the level of depression, the Korean version of the Center for Epidemiologic Studies Depression Scale (CES-D) was used. Setting: South Korea. Participants: Male adults who underwent routine health check-ups. Results: The average vitamin D level was 22·31 ± 7·09 ng/ml as 25(OH)D, while the number of subjects in the vitamin D insufficiency group with a finding of <20 ng/ml was 3783 (41·8 %). The mean CES-D score in all subjects was 8·31 ± 5·97 points, and the proportion of the depressive symptoms group with a score of ≥16 was 8·71 %. The OR of patients in the depressive symptoms group also being in the insufficiency group was found to be 1·49 (95 % CI 1·12, 2·00). Conclusions: A total of 41·8 % of apparently healthy male adults had vitamin D levels <20 ng/ml. We identified an association between vitamin D insufficiency and depressive symptoms in apparently healthy Korean male adults.

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Section: Strengths and Limitations Of The Present Studymentioning

confidence: 81%

Association between serum vitamin D and depressive symptoms in apparently healthy male adults undergoing routine health check-ups at a single centre

Kim

Lee

Chae

et al. 2020

Public Health Nutr.

View full text Add to dashboard Cite

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“…Выделяют «классические» эффекты витамина D, связанные с его влиянием на кальцие-во-фосфорный обмен и минеральную плотность костной ткани, и «неклассические» биологические эффекты. К «неклассическим» (внекостным) эффектам витамина относят торможение клеточной пролиферации и ангиогенеза, стимуляцию продукции инсулина и кателицидинов (противомикробных пептидов), ингибирование продукции ренина, противовоспалительное, иммуномодулирующее, антибактериальное, противоопухолевое и ряд других свойств [2,5,6,7,8].…”

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Current trends in analytical determination of vitamin D

Хабаров

Vislotskiy

Denisova

et al. 2020

Medicinskij alfavit

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Measurement of vitamin D has increased significantly in recent years. Most studies focused on 25(OH)D, which is considered the best indicator of vitamin D status, while there is now more interest in the combined measurement of several clinically significant vitamin D metabolites using the LC–MS/MS technique, which allows simultaneous determination of various vitamin D metabolites over a wide dynamic range. Multi-panel LC–MS/MS analyses are likely to improve future research on the optimal combination of metabolites to assess vitamin D sufficiency, as well as help us better understand its metabolism in normal and pathological changes in the human body. The review examines current trends in analytical determination of vitamin D status and their application in clinical studies.

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Sufficient Status of Vitamin D, Cobalamin and Folate in Healthy and Active German Home-Dwelling People Over 70 Years of Age

Kerlikowsky

Hahn

2023

Preprint

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Background: Ageing is characterised by physiological changes that can affect the nutrient availability and requirements. In particular, the status of vitamin D, cobalamin and folate has often been found to be critical in older people living in residential care. However, there is a lack of studies investigating the status of these nutrients in healthy and active home-dwelling elderly people. Methods: The aim of this cross-sectional study was to assess the status of vitamin D based on serum concentrations of 25-hydroxycholecalciferol [25-(OH)D], cobalamin based on serum concentrations of holotranscobalamin (holoTC) and folate based on red blood cell (RBC) folate in unsupplemented, healthy and active German home-dwelling subjects ≥70 years of age (n=134, mean±SD: 75.8±4.5 years). Dietary intake was assessed by 3-day food recalls. The study was conducted between March and November of 2021 (during the COVID-19 pandemic). Results: The mean 25-(OH)D concentration was unexpectedly high at 85.1±26.0 nmol/L, while the majority of women (63%) and men (84%) had 25-(OH)D concentrations ≥75 nmol/L. Less than 10% of men and women had 25-(OH)D concentrations <50 nmol/L. The mean holoTC concentration was 88.9±33.7 pmol/L. Women had significantly higher holoTC concentrations (94.8±34.6 pmol/L) than men (73.6±25.6 pmol/L), despite lower consumption of meat, eggs and meat products. Only 8% of the women were cobalamin deficient (<50 pmol/L holoTC) compared to 22% of the men. The mean RBC folate concentration was 831±244 nmol/L, while the prevalence of folate deficiency was 10%. Linear regression analysis showed that age (range: 70 to 100 years) was not associated with the nutrient status. Conclusion: Our findings suggest that healthy, independently living older people with high levels of education, physical activity, and health awareness are not necessarily at higher risk of vitamin D, folate and cobalamin deficiency. However, it should be noted that about 10 % of the study collective were deficit in these vitamins. Further studies are needed to verify these findings and to identify lifestyle and dietary patterns that can predict adequate nutrient status for healthy ageing. Trial registration: This study is officially recorded in the German Clinical Trials Register (DRKS00021302).

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Current trends in the analytical determination of vitamin D

Abstract: We thank the company Traducciones Bienza, as well as its translator Megan Mundt, for having made possible the translation of this review.

Cited by 4 publications

References 27 publications

Association between serum vitamin D and depressive symptoms in apparently healthy male adults undergoing routine health check-ups at a single centre

Association between serum vitamin D and depressive symptoms in apparently healthy male adults undergoing routine health check-ups at a single centre

Current trends in analytical determination of vitamin D

Sufficient Status of Vitamin D, Cobalamin and Folate in Healthy and Active German Home-Dwelling People Over 70 Years of Age

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