“…In this study, we used MindTriggers app ( Moussavi, 2020 ) that includes a series of seven cognitive exercises (games) targeting strengthening the executive function of the brain, its left-right hemisphere connectivity and spatial orientation. We tested the efficacy of an intense cognitive exercises program (4 weeks, 5 days/week) on 28 individuals with dementia at mild and moderate stages in two groups: A) tACS + Exr Group: receiving tACS simultaneously with cognitive exercises, and B) Exr Group: receiving only cognitive exercises; both groups received the cognitive exercises with a trainer at our labs.…”
Section: Discussionmentioning
confidence: 99%
“…The treatment protocol is to deliver the cognitive exercises of MindTriggers app ( Moussavi, 2020 ) on an iPad with a trained tutor of our team on a daily basis for 4 weeks consecutively (excluding weekends, 20 sessions in total). Each daily treatment includes two 30 min duration cognitive exercises.…”
Section: Methodsmentioning
confidence: 99%
“…We used the exercises within the MindTriggers app ( Moussavi, 2020 ) delivered on an iPad. The exercises in this app were conceptually designed by the first author based on neuroplasticity of the brain and the most impaired cognitive functions in individuals with dementia, particularly Alzheimer’s.…”
The effects of cognitive exercises on the healthy aging population is controversial. Transcranial alternating current stimulation (tACS) is considered a promising tool for modulating brain oscillation. Research is lacking on its long-lasting cognitive/therapeutic effect. This is the first pilot study to explore the effect of a regimen of cognitive exercises with and without tACS on older adults with dementia. The study groups were 28 individuals (age 56–83 years) enrolled into two groups: Exr Group, who received cognitive exercises only and the Exr + tACS Group who received tACS at 40 Hz simultaneously with cognitive exercises for a period of 4 consecutive weeks, 5 days/week, two 30 min-sessions/day; all the training sessions were tutored. The cognitive exercises were applied using the MindTriggers app. They were assessed at pre and post intervention and also one month after the end of trial (follow-up) with an independent assessment (WMS-IV) as the primary outcome measure. The results show significant cognitive improvement at post-intervention in both groups, while the Exr + tACS protocol lead to superior cognitive improvement at follow-up session. The most important outcomes of this study are: 1) The tutored repeated practice of the MindTriggers app exercises does significantly improve the cognitive functions of older adults with dementia and that that improvement lasts for at least one month after the end of the intervention, and 2) The application of tACS increases the positive effects of cognitive exercises with the positive effect lasting an even longer period of time than exercises alone; in other words we speculate that it may lead to long-term potentiation.
“…In this study, we used MindTriggers app ( Moussavi, 2020 ) that includes a series of seven cognitive exercises (games) targeting strengthening the executive function of the brain, its left-right hemisphere connectivity and spatial orientation. We tested the efficacy of an intense cognitive exercises program (4 weeks, 5 days/week) on 28 individuals with dementia at mild and moderate stages in two groups: A) tACS + Exr Group: receiving tACS simultaneously with cognitive exercises, and B) Exr Group: receiving only cognitive exercises; both groups received the cognitive exercises with a trainer at our labs.…”
Section: Discussionmentioning
confidence: 99%
“…The treatment protocol is to deliver the cognitive exercises of MindTriggers app ( Moussavi, 2020 ) on an iPad with a trained tutor of our team on a daily basis for 4 weeks consecutively (excluding weekends, 20 sessions in total). Each daily treatment includes two 30 min duration cognitive exercises.…”
Section: Methodsmentioning
confidence: 99%
“…We used the exercises within the MindTriggers app ( Moussavi, 2020 ) delivered on an iPad. The exercises in this app were conceptually designed by the first author based on neuroplasticity of the brain and the most impaired cognitive functions in individuals with dementia, particularly Alzheimer’s.…”
The effects of cognitive exercises on the healthy aging population is controversial. Transcranial alternating current stimulation (tACS) is considered a promising tool for modulating brain oscillation. Research is lacking on its long-lasting cognitive/therapeutic effect. This is the first pilot study to explore the effect of a regimen of cognitive exercises with and without tACS on older adults with dementia. The study groups were 28 individuals (age 56–83 years) enrolled into two groups: Exr Group, who received cognitive exercises only and the Exr + tACS Group who received tACS at 40 Hz simultaneously with cognitive exercises for a period of 4 consecutive weeks, 5 days/week, two 30 min-sessions/day; all the training sessions were tutored. The cognitive exercises were applied using the MindTriggers app. They were assessed at pre and post intervention and also one month after the end of trial (follow-up) with an independent assessment (WMS-IV) as the primary outcome measure. The results show significant cognitive improvement at post-intervention in both groups, while the Exr + tACS protocol lead to superior cognitive improvement at follow-up session. The most important outcomes of this study are: 1) The tutored repeated practice of the MindTriggers app exercises does significantly improve the cognitive functions of older adults with dementia and that that improvement lasts for at least one month after the end of the intervention, and 2) The application of tACS increases the positive effects of cognitive exercises with the positive effect lasting an even longer period of time than exercises alone; in other words we speculate that it may lead to long-term potentiation.
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