Current Trends in Fabrication of Biomaterials for Bone and Cartilage Regeneration: Materials Modifications and Biophysical Stimulations

Przekora, Agata

doi:10.3390/ijms20020435

Cited by 76 publications

(61 citation statements)

References 123 publications

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“…The organic part of biomaterial provides biomaterial flexibility and improves its biocompatibility [21][22][23], whereas the inorganic part provides load-bearing strength and stiffness [22]. In organic-inorganic composites, the organic matrix may be composed of natural polymers (e.g., chitosan, collagen, hyaluronic acid, fibrin, silk fibroin, alginate, amylopectin, carrageenan, agar, dextran, xanthan gum, pullulan) [15,[23][24][25][26] and/or synthetic polymers (e.g., polylactic acid (PLA), polycaprolactone (PCL), poly(glycolic acid) (PGA), polyanhydride, polyphosphazene, polyether ether ketone (PEEK), polypropylene fumarate (PPF)) [27], whereas the inorganic part may be made of metal alloys [16] and ceramics, such as hydroxyapatite (HA), calcium phosphate bone cements (CPS), α-tricalcium phosphate (α-TCP), β-tricalcium phosphate (β-TCP), Bioglass (BG), glass-ceramics, as well as carbon nanotubes [15,24,27,28].…”

Section: Bone Regenerative Medicinementioning

confidence: 99%

“…Moreover, the piezoelectric biomaterials may generate a bioelectrical signal influenced by mechanical stress exposure, that may mimic the stress-generated potentials of natural bone. This type of biomaterials may also be subjected to electrical stimulation or ultrasound to promote bone healing [25]. Fan et al [46] used BaTiO 3 to modify the surface of Ti scaffold.…”

Section: Inorganic and Composite Coatingsmentioning

confidence: 99%

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Osteoconductive and Osteoinductive Surface Modifications of Biomaterials for Bone Regeneration: A Concise Review

Kazimierczak

Przekora

2020

Coatings

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The main aim of bone tissue engineering is to fabricate highly biocompatible, osteoconductive and/or osteoinductive biomaterials for tissue regeneration. Bone implants should support bone growth at the implantation site via promotion of osteoblast adhesion, proliferation, and formation of bone extracellular matrix. Moreover, a very desired feature of biomaterials for clinical applications is their osteoinductivity, which means the ability of the material to induce osteogenic differentiation of mesenchymal stem cells toward bone-building cells (osteoblasts). Nevertheless, the development of completely biocompatible biomaterials with appropriate physicochemical and mechanical properties poses a great challenge for the researchers. Thus, the current trend in the engineering of biomaterials focuses on the surface modifications to improve biological properties of bone implants. This review presents the most recent findings concerning surface modifications of biomaterials to improve their osteoconductivity and osteoinductivity. The article describes two types of surface modifications: (1) Additive and (2) subtractive, indicating biological effects of the resultant surfaces in vitro and/or in vivo. The review article summarizes known additive modifications, such as plasma treatment, magnetron sputtering, and preparation of inorganic, organic, and composite coatings on the implants. It also presents some common subtractive processes applied for surface modifications of the biomaterials (i.e., acid etching, sand blasting, grit blasting, sand-blasted large-grit acid etched (SLA), anodizing, and laser methods). In summary, the article is an excellent compendium on the surface modifications and development of advanced osteoconductive and/or osteoinductive coatings on biomaterials for bone regeneration.

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Section: Bone Regenerative Medicinementioning

confidence: 99%

Section: Inorganic and Composite Coatingsmentioning

confidence: 99%

Osteoconductive and Osteoinductive Surface Modifications of Biomaterials for Bone Regeneration: A Concise Review

Kazimierczak

Przekora

2020

Coatings

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“…Scaffolds are useful substrates to study the effect of plasma-derived ROS on growth and invasion of cancer cells. Previous studies have shown that plasma can change the biophysical properties of polymers, as it can enhance the polymerization and biophysical stimulation of biomaterials used for bone and cartilage regeneration [290,291]. Thus, it could be expected that plasma would oxidize or modify the properties of these scaffolds in 3D cultures, therefore providing relevant information about the effect of plasma on the ECM and cells of the TME under oxidative stress.…”

Section: Scaffoldsmentioning

confidence: 99%

Modifying the Tumour Microenvironment: Challenges and Future Perspectives for Anticancer Plasma Treatments

Privat-Maldonado

Bengtson

Razzokov

et al. 2019

Cancers

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Tumours are complex systems formed by cellular (malignant, immune, and endothelial cells, fibroblasts) and acellular components (extracellular matrix (ECM) constituents and secreted factors). A close interplay between these factors, collectively called the tumour microenvironment, is required to respond appropriately to external cues and to determine the treatment outcome. Cold plasma (here referred as ‘plasma’) is an emerging anticancer technology that generates a unique cocktail of reactive oxygen and nitrogen species to eliminate cancerous cells via multiple mechanisms of action. While plasma is currently regarded as a local therapy, it can also modulate the mechanisms of cell-to-cell and cell-to-ECM communication, which could facilitate the propagation of its effect in tissue and distant sites. However, it is still largely unknown how the physical interactions occurring between cells and/or the ECM in the tumour microenvironment affect the plasma therapy outcome. In this review, we discuss the effect of plasma on cell-to-cell and cell-to-ECM communication in the context of the tumour microenvironment and suggest new avenues of research to advance our knowledge in the field. Furthermore, we revise the relevant state-of-the-art in three-dimensional in vitro models that could be used to analyse cell-to-cell and cell-to-ECM communication and further strengthen our understanding of the effect of plasma in solid tumours.

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“…In the field of biomaterials engineering, cold plasma technology is primarily used for surface functionalization with hydrophilic chemical groups to enhance cell adhesion and proliferation on the implants [ 10 ]. Atmospheric pressure plasma is also used to improve surface properties of the biomaterials, especially wettability and roughness that are known to significantly influence biocompatibility of the implants [ 11 , 12 ]. Materials scientists frequently use atmospheric pressure plasma combined with oxygen, argon, air, ammonia, or nitrogen gas for biocompatibility improvement of various polymeric biomaterials [ 5 , 6 , 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Positive Effect of Cold Atmospheric Nitrogen Plasma on the Behavior of Mesenchymal Stem Cells Cultured on a Bone Scaffold Containing Iron Oxide-Loaded Silica Nanoparticles Catalyst

Przekora

Audemar

Pawłat

et al. 2020

IJMS

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Low-temperature atmospheric pressure plasma was demonstrated to have an ability to generate different reactive oxygen and nitrogen species (RONS), showing wide biological actions. Within this study, mesoporous silica nanoparticles (NPs) and FexOy/NPs catalysts were produced and embedded in the polysaccharide matrix of chitosan/curdlan/hydroxyapatite biomaterial. Then, basic physicochemical and structural characterization of the NPs and biomaterials was performed. The primary aim of this work was to evaluate the impact of the combined action of cold nitrogen plasma and the materials produced on proliferation and osteogenic differentiation of human adipose tissue-derived mesenchymal stem cells (ADSCs), which were seeded onto the bone scaffolds containing NPs or FexOy/NPs catalysts. Incorporation of catalysts into the structure of the biomaterial was expected to enhance the formation of plasma-induced RONS, thereby improving stem cell behavior. The results obtained clearly demonstrated that short-time (16s) exposure of ADSCs to nitrogen plasma accelerated proliferation of cells grown on the biomaterial containing FexOy/NPs catalysts and increased osteocalcin production by the cells cultured on the scaffold containing pure NPs. Plasma activation of FexOy/NPs-loaded biomaterial resulted in the formation of appropriate amounts of oxygen-based reactive species that had positive impact on stem cell proliferation and at the same time did not negatively affect their osteogenic differentiation. Therefore, plasma-activated FexOy/NPs-loaded biomaterial is characterized by improved biocompatibility and has great clinical potential to be used in regenerative medicine applications to improve bone healing process.

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Current Trends in Fabrication of Biomaterials for Bone and Cartilage Regeneration: Materials Modifications and Biophysical Stimulations

Cited by 76 publications

References 123 publications

Osteoconductive and Osteoinductive Surface Modifications of Biomaterials for Bone Regeneration: A Concise Review

Osteoconductive and Osteoinductive Surface Modifications of Biomaterials for Bone Regeneration: A Concise Review

Modifying the Tumour Microenvironment: Challenges and Future Perspectives for Anticancer Plasma Treatments

Positive Effect of Cold Atmospheric Nitrogen Plasma on the Behavior of Mesenchymal Stem Cells Cultured on a Bone Scaffold Containing Iron Oxide-Loaded Silica Nanoparticles Catalyst

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