Current trends in antimalarial chemotherapy

Kumar, Arun; Katiyar, Sanjay Babu; Agarwal, Anu; Chauhan, Prem M. S.

doi:10.1358/dof.2003.028.03.720299

Cited by 33 publications

(7 citation statements)

References 8 publications

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“…Malaria is an old age tropical infectious parasitic disease, which affects 300-500 million people worldwide with 1-3 million deaths every year. [1][2][3][4][5][6][7][8] It is caused by infections of protozoan parasite of the genus Plasmodium. Five species of Plasmodium parasite viz P. vivax, P. ovale, P. malariae, P. knowlein and P. falciparum can infect humans; out of these P. falciparum is the most dangerous and it accounts half of all clinical cases of malaria.…”

Section: Introductionmentioning

confidence: 99%

Tetraoxanes: Synthetic and Medicinal Chemistry Perspective

Kumar¹,

Savan²,

Rawat

2010

Medicinal Research Reviews

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The discovery of artemisinin from Chinese medicinal plant, Artemisia annua in 1971, opened a new era in the malarial chemotherapy. This discovery was the beginning of exploring peroxides as potential replacements for the traditional antimalarial drugs such as chloroquine and mefloquine. The structurally simple class of peroxides that emerged from these studies was the 1,2,4,5-tetraoxanes. This study describes the current status of tetraoxane-based antimalarials that show significant promises because of their artemisinin-like activity. Literature from 1999 has been critically reviewed and an attempt has been made to discuss various synthetic methods and structure-activity relationship study among the series of tetraoxane-based compounds. © 2010 Wiley Periodicals, Inc. Med Res Rev.

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Section: Introductionmentioning

confidence: 99%

Tetraoxanes: Synthetic and Medicinal Chemistry Perspective

Kumar¹,

Savan²,

Rawat

2010

Medicinal Research Reviews

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“…[1][2][3] Plasmodium falciparum, the causative agent of the most malignant forms of malaria is a particularly resistant parasite, which is known to have high adaptability by mutation. This mutability makes quite likely the development of resistance to chemotherapies currently being introduced.…”

Section: Introductionmentioning

confidence: 99%

Syntheses of 2,4,6-trisubstituted triazines as antimalarial agents

Agarwal

Srivastava

Puri

et al. 2005

Bioorganic & Medicinal Chemistry Letters

113

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“…The main progress refers to research in the area of steroids, alkaloids, nucleosides, macrolides, prostaglandins, and amino acids ( Kumar et al, 2008 ). Quinine isolated from chinchona bark led successive and innovative class of antimalarials ( Kumar et al, 2003 ) such as chloroquine, mefloquine, and primaquine. Another example is the fluorocorticoid and fluorouracil derivatives, these drugs are still clinically used ( Bégué and Bonnet-Delpon, 2006 ).…”

Section: Introductionmentioning

confidence: 99%

Novel Alkyl(aryl)-Substituted 2,2-Difluoro-6-(trichloromethyl)-2H-1,3,2-oxazaborinin-3-ium-2-uides: Synthesis, Antimicrobial Activity, and CT-DNA Binding Evaluations

et al. 2020

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The synthesis, antimicrobial activity evaluations, biomolecule-binding properties (DNA), and absorption and emission properties of a new series of (Z)-1,1,1-trichloro-4-alkyl(aryl) amino-4-arylbut-3-en-2-ones (4, 5) and 2,2-difluoro-3-alkyl(aryl)amino-4-aryl-6-(trichloromethyl)-2H-1,3,2-oxazaborinin-3-ium-2-uides (6, 7) in which 3(4)-alkyl(aryl) = H, Me, iso-propyl, n-butyl, C 6 H 5 , 4-CH 3 C 6 H 4 , 4-CH 3 OC 6 H 4 , 4-NO 2 C 6 H 4 , 4-FC 6 H 4 , 4-BrC 6 H 4 , 2-naphthyl, is reported. A series of b-enaminoketones (4, 5) is synthesized from the O,N-exchange reaction of some amines (3) with (Z)-1,1,1-trichloro-4-methoxy-4-arylbut-3-en-2-ones (1, 2) at 61-90% yields. Subsequently, reactions of the resulting benaminoketones with an appropriate source of boron (BF 3 .OEt 2) gave the corresponding oxazaborinine derivatives (6, 7) at 50-91% yields. UV-Vis and emission properties of biomolecule-binding properties for the DNA of these new BF 2-b-enamino containing CCl 3 units were also evaluated. Some compounds from the present series also exhibited potent antimicrobial effects on various pathogenic microorganisms at concentrations below those that showed cytotoxic effects. Compounds 4d, 4e, 6e, and 6f showed the best results and are very significant against P. zopfii, which causes diseases in humans and animals.

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Current trends in antimalarial chemotherapy

Cited by 33 publications

References 8 publications

Tetraoxanes: Synthetic and Medicinal Chemistry Perspective

Tetraoxanes: Synthetic and Medicinal Chemistry Perspective

Syntheses of 2,4,6-trisubstituted triazines as antimalarial agents

Novel Alkyl(aryl)-Substituted 2,2-Difluoro-6-(trichloromethyl)-2H-1,3,2-oxazaborinin-3-ium-2-uides: Synthesis, Antimicrobial Activity, and CT-DNA Binding Evaluations

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