Current treatment strategies in pediatric gastrointestinal stromal cell tumor

Willobee, Brent A.; Quiroz, Hallie J.; Sussman, Matthew S.; Thorson, Chad M.; Sola, Juan E.; Pérez, Eduardo A.

doi:10.21037/tgh.2018.07.09

Cited by 10 publications

(5 citation statements)

References 42 publications

(45 reference statements)

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“…All tumours of mesenchymal origin that express the membrane protein kit (CD117) or which have a mutation in platelet-derived-growth factor a (PDGFRA) should be considered as GISTs [ 3 – 6 ].…”

Section: Epidemiology Biology and Clinical Aspectsmentioning

confidence: 99%

International Society of Paediatric Surgical Oncology (IPSO) Surgical Practice Guidelines

Abib¹,

Chui²,

Cox³

et al. 2022

ecancer

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Most children with tumors will require one or more surgical interventions as part of the care and treatment, including making a diagnosis, obtaining adequate venous access, performing a surgical resection for solid tumors (with staging and reconstruction), performing procedures for cancer prevention and its late effects, and managing complications of treatment; all with the goal of improving survival and quality of life. It is important for surgeons to adhere to sound pediatric surgical oncology principles, as they are closely associated with improved local control and survival. Unfortunately, there is a significant disparity in survival rates in low and middle income countries, when compared to those from high income countries.The International Society of Paediatric Surgical Oncology (IPSO) is the leading organization that deals with pediatric surgical oncology worldwide. This organization allows experts in the field from around the globe to gather and address the surgical needs of children with cancer. IPSO has been invited to contribute surgical guidance as part of the World Health Organization Initiative for Childhood Cancer. One of our goals is to provide surgical guidance for different scenarios, including those experienced in High-(HICs) and Low-and Middle-Income Countries (LMICs). With this in mind, the following guidelines have been developed by authors from both HICs and LMICs. These have been further validated by experts with the aim of providing evidence-based information for surgeons who care for children with cancer.We hope that this initiative will benefit children worldwide in the best way possible.

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Section: Epidemiology Biology and Clinical Aspectsmentioning

confidence: 99%

International Society of Paediatric Surgical Oncology (IPSO) Surgical Practice Guidelines

Abib¹,

Chui²,

Cox³

et al. 2022

ecancer

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“…Due to the complexity of the mutations involved in pediatric GIST and its consequences in therapeutic management, the importance of referral to specialized centers should be emphasized when determining adjuvant therapies for the pediatric patient presenting with GIST. [15] Taking into account all of the above, we can conclude that pediatric GISTs are extremely rare, therefore, diagnoses are usually made with delays. GISTs should be considered as a differential diagnosis in patients with anemia and gastrointestinal bleeding.…”

Section: Discussionmentioning

confidence: 99%

Gastrointestinal stromal tumor as an unusual cause of gastrointestinal bleeding in pediatrics.

2021

J Med Case Rep Case Ser

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Background: Gastrointestinal stromal tumors are defined as tumors of mesenchymal origin, specifically of the interstitial cells of Cajal.In pediatric age it is very rare and a different entity from the adult form.Objective: Due to the unusualness of this entity, and the difficulties that may exist for its diagnosis and behavior, we present this case in pediatric age. Case presentation:A 10-year-old schoolchild who started with anemia and high digestive bleeding, usually in the form of a melena, which required blood transfusion. She was admitted several times without reaching an accurate etiology. The performance of abdominal ultrasound, Upper Digestive Endoscopy with Echoendoscope, Computed Tomography of the abdomen and histological study allowed the diagnosis of a gastric stromal gastric tumor, without metastatic lesion. Subtotal gastrectomy was performed, with good evolution of the patient. The presented case corresponds to some of the clinical characteristics described for patients with pediatric gastrointestinal stromal tumor. Conclusions:Pediatric gastrointestinal stromal tumors are extremely rare; therefore, diagnosis is usually made late. These should be considered as a possible diagnosis in those patients with anemia and gastrointestinal bleeding. The diagnostic approach of this type of tumors is multidisciplinary.

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“…It also allows for the classification of GIST: some children have an adult-type tumor that possesses KIT or PDGFRA mutations, which may allow for the use of imatinib (especially exon 9 or 11 KIT mutations that are sensitive to imatinib treatment) [ 8 ]. Pediatric-type GIST may be treated with different agents compatible with the exact genetic alterations [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Latest Advances in the Management of Pediatric Gastrointestinal Stromal Tumors

Andrzejewska

Czarny

Derwich

2022

Cancers

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Gastrointestinal stromal tumor is the most common mesenchymal neoplasm of the gastrointestinal tract, usually found in elderly adults. It is infrequent among pediatric patients and usually differs biologically from adult-type diseases presenting mutations of KIT and PDGFR genes. In this population, more frequent is the wild-type GIST possessing SDH, TRK, RAS, NF1 mutations, among others. Both tumor types require individualized treatment with kinase inhibitors that are still being tested in the pediatric population due to the different neoplasm biology. We review the latest updates to the management of pediatric gastrointestinal tumors with a particular focus on the advances in molecular biology of the disease that enables the definition of possible resistance. Emerging treatment with kinase inhibitors that could serve as targeted therapy is discussed, especially with multikinase inhibitors of higher generation, the effectiveness of which has already been confirmed in the adult population.

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Current treatment strategies in pediatric gastrointestinal stromal cell tumor

Cited by 10 publications

References 42 publications

International Society of Paediatric Surgical Oncology (IPSO) Surgical Practice Guidelines

International Society of Paediatric Surgical Oncology (IPSO) Surgical Practice Guidelines

Gastrointestinal stromal tumor as an unusual cause of gastrointestinal bleeding in pediatrics.

Latest Advances in the Management of Pediatric Gastrointestinal Stromal Tumors

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