Current treatment strategies: Collagen vascular diseases in children

Palit, Aparna; Inamadar, Arun C

doi:10.4103/0019-5154.103064

Cited by 5 publications

(3 citation statements)

References 49 publications

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“…NLE can affect the cardiac system which mostly manifest cardiac block, and the other systems such as dermal, hepatic, hematological and sometimes central nervous system [15]. Poor prognosis is seen in cardiac block patients [5].…”

Section: Discussionmentioning

confidence: 99%

High-risk groups of neonatal lupus erythematosus in term infants: a birth cohort study

Ma,

Li,

Song

et al. 2023

Eur J Pediatr

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Purpose: This study aims to analyse the clinical characteristics and risk factors of high-risk groups of neonatal lupus erythematosus (NLE) in term infants.Methods: The high-risk groups of NLE whose mothers were positive of anti-SSA, SSB or U1RNP antibodies during pregnancy were enrolled.They were born from February 2013 to February 2020, with a gestational age not less than 37 weeks. We analyzed their clinical data from birth to 24 months after birth.Results: A total number of 105 cases of NLE high-risk groups were included. Among them, 30 cases were diagnosed with NLE (NLE group) and 75 cases were not (non-NLE group). The affected systems of the NLE group included dermal (13.3%), hepatic (76.0%), and hematological system (43.3%). Hepatic involvement, anemia and thrombocytopenia could not emerge until 60 days, 41 days and 22 days after birth in some cases. The systems involvement could be cured within 3 to 12 months after birth. The clearance time of speci c autoantibodies was 12 months after birth. There was no signi cant difference in clinical characteristics of babies and their mothers between the two groups, neither of the positive rate or clearance time of speci c autoantibodies.Conclusion: After standardized prenatal health care, there is still a high risk of dermal, hepatic, or hematological system involvement for high-risk groups of NLE. There are no speci c indicators to predict whether the babies will develop to NLE or not. All of them need to be followed up closely within one year after birth.

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Section: Discussionmentioning

confidence: 99%

High-risk groups of neonatal lupus erythematosus in term infants: a birth cohort study

Ma,

Li,

Song

et al. 2023

Eur J Pediatr

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“…Autoimmune conditions such as systemic lupus erythematosus and other collagen vascular diseases can cause pulmonary fibrosis in children. [34][35][36] Juvenile idiopathic arthritis (JIA) comprises a group of inflammatory disorders characterized by systemic symptoms and multiorgan damage. 37 While ILD is a relatively rare occurrence in JIA, the presence of ILD is associated with severe symptoms and a high mortality rate.…”

Section: Pulmonary Fibrosis With Acquired Causes In Childrenmentioning

confidence: 99%

“…However, pulmonary function testing may be more challenging in children and changes that occur with lung growth continue to make diagnosis, treatment, and monitoring of lung health challenging. Autoimmune conditions such as systemic lupus erythematosus and other collagen vascular diseases can cause pulmonary fibrosis in children 34–36 . Juvenile idiopathic arthritis (JIA) comprises a group of inflammatory disorders characterized by systemic symptoms and multiorgan damage 37 .…”

Section: Pulmonary Fibrosis In Childrenmentioning

confidence: 99%

Imaging of pulmonary fibrosis in children: A review, with proposed diagnostic criteria

DeBoer,

Weinman,

Ley‐Zaporozhan

et al. 2024

Pediatric Pulmonology

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Computed tomography (CT) imaging findings of pulmonary fibrosis are well established for adults and have been shown to correlate with prognosis and outcome. Recognition of fibrotic CT findings in children is more limited. With approved treatments for adult pulmonary fibrosis, it has become critical to define CT criteria for fibrosis in children, to identify patients in need of treatment and those eligible for clinical trials. Understanding how pediatric fibrosis compares with idiopathic pulmonary fibrosis and other causes of fibrosis in adults is increasingly important as these patients transition to adult care teams. Here, we review what is known regarding the features of pulmonary fibrosis in children compared with adults. Pulmonary fibrosis in children may be associated with genetic surfactant dysfunction disorders, autoimmune systemic disorders, and complications after radiation, chemotherapy, transplantation, and other exposures. Rather than a basal‐predominant usual interstitial pneumonia pattern with honeycombing, pediatric fibrosis is primarily characterized by reticulation, traction bronchiectasis, architectural distortion, or cystic lucencies/abnormalities. Ground‐glass opacities are more frequent in children with fibrotic interstitial lung disease than adults, and disease distribution appears more diffuse, without clearly defined axial or craniocaudal predominance. Following discussion and consensus amongst a panel of expert radiologists, pathologists and physicians, distinctive disease features were integrated to develop criteria for the first global Phase III trial in children with pulmonary fibrosis.

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Collagen Vascular Disease: Cutaneous Lupus Erythematosus

Marimar¹,

Luz²

2015

Pediatric Skin of Color

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Current treatment strategies: Collagen vascular diseases in children

Cited by 5 publications

References 49 publications

High-risk groups of neonatal lupus erythematosus in term infants: a birth cohort study

High-risk groups of neonatal lupus erythematosus in term infants: a birth cohort study

Imaging of pulmonary fibrosis in children: A review, with proposed diagnostic criteria

Collagen Vascular Disease: Cutaneous Lupus Erythematosus

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