Current treatment status of polycystic liver disease in Japan

Abstract

Considering the therapeutic effects and complications, AS, LR and LT showed good results for type I, type II and type III PLD, respectively. However, LT for PLD was performed in a small number of patients. In Japan, the transplantation therapy is expected to be common in the future.

Prediction of hepatic cyst recurrence after minocycline hydrochloride aspiration sclerotherapy using cyst computed tomography values

“…Percutaneous cyst aspiration sclerotherapy using minocycline is considered effective for type 1 disease according to Gigot's classification for polycystic liver disease, that is, small numbers of huge liver cysts. However, the relapse rate is significant and mass‐reduction effect was blunted after 1 year in some patients.…”

Comparison of volume‐reductive therapies for massive polycystic liver disease in autosomal dominant polycystic kidney disease

“…Few studies have compared the outcomes from different volume‐reductive therapies in PLD patients at single centers, and consensus regarding treatment selection has not been reached . In this study, we compared the outcomes of TAE, liver resection and LT for symptomatic PLD in ADPKD at a single center.…”

Repeated Minocycline Hydrochloride Injections for Symptomatic Polycystic Liver Disease

“…The recurrence rate after liver resection has been reported to be 3% to 33% [56][57][58] . In Japan, postoperative complications of liver resection include ascites, bile leakage, and intra abdominal abscess, with an incidence of 31.8% [59] . Cyst fenestration, i.e., surgical de roofing of a cyst, is a minimally invasive surgical treatment, but the recurrence rate has been reported to range from 20% to 72%, with large differences among previous studies [60][61][62][63] .…”

“…Aspiration sclerotherapy involves cyst aspiration followed by the injection of a sclerosing agent, which destroys the epithelial cells lining the cyst cavity. However, aspiration sclerotherapy for PLD was reported to be impractical because of its high recurrence rate, ranging from 50% to 78% [36,59] . The most commonly used sclerosing agent is ethanol or MINO.…”

“…It reflects disease severity and is useful when choosing treatment options. Recently, several reports on PLD treatment have recommended aspiration sclerotherapy, cyst fenestration, and liver resection for Gigot type 1 or 2 PLD and liver transplantation for type 3 PLD; however, no standardized criteria for the selection of treatment exist [5,23,35,46,59,64,65,[73][74][75] . In our series, all patients had Gigot type 2 PLD.…”