Current treatment outcomes of congenital heart disease and future perspectives

Ma, Kai; He, Qiyu; Dou, Zheng; Hou, Xiaotong; Li, Xi; Zhao, Jun; Rao, Chenfei; Feng, Zhen; Sun, Kun; Chen, Xinxin; He, Yihua; Zhang, Hao; Li, Shoujun

doi:10.1016/s2352-4642(23)00076-7

Cited by 14 publications

(10 citation statements)

References 71 publications

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“…ChiCTR1800014577). 17 All hospitalized patients underwent congenital cardiac surgery were included and clinic patients were excluded due to incomplete profile. The CHD diagnoses were confirmed by ultrasonography and surgical notes, and standardized by the International Classification of Disease and Injuries 10 th edition (ICD-10) during their entry to CDCHS.…”

Section: Methodsmentioning

confidence: 99%

Failure to thrive in pediatric patients with congenital heart disease: a cross-sectional study of 13,256 patients

He,

Lin,

Zhou

et al. 2024

The Lancet Regional Health - Western Pacific

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Section: Methodsmentioning

confidence: 99%

Failure to thrive in pediatric patients with congenital heart disease: a cross-sectional study of 13,256 patients

He,

Lin,

Zhou

et al. 2024

The Lancet Regional Health - Western Pacific

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“…The reported incidence of CHD in neonates ranges from 2 to 10 per 1000 live births, impacting approximately 1.35 million infants worldwide each year 3 4 . Among infants and young children, CHDs constitute a significant proportion of non-infectious morbidity and mortality attributed to congenital anomalies 5 . Therefore, it is important to determine the potential risk factor of CHD.…”

Section: Introductionmentioning

confidence: 99%

Maternal Gestational Diabetes Mellitus and Congenital Heart Disease in Offspring: A Meta-Analysis

Liu,

Yue,

Chang

2024

Horm Metab Res

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Maternal diabetes has been related to an increased risk of congenital heart disease (CHD) in offspring. However, inconsistent results were retrieved for studies evaluating the association between gestational diabetes mellitus (GDM) and CHD in offspring. We therefore performed a systematic review and meta-analysis for comprehensive investigation. Observational studies were identified by searching PubMed, Embase, and Web of Science according to the aim of the meta-analysis. A randomized-effects model was used to pool the data by incorporating the influence of potential heterogeneity. Twenty-three observational studies, involving 46953078 mother-child pairs, were available for the meta-analysis. Among them, 2131800 mothers were diagnosed as GDM and 214379 newborns had CHD. Overall, maternal GDM was associated with a higher incidence of CHD in offspring [odds ratio (OR): 1.32, 95% confidence interval (CI): 1.21 to 1.45, p<0.001; I2=62%]. Sensitivity analysis limited to studies with adjustment of maternal age and other potential confounding factors showed similar results (OR: 1.40, 95% CI: 1.30 to 1.51, p<0.001; I2=47%). Subgroup analysis suggested that the association between maternal GDM and CHD in offspring was not significantly affected by methods for diagnosis of GDM, methods for confirmation of CHD, or study quality scores (p for subgroup difference all>0.05). Subsequent analysis according to types of CHD showed that maternal GDM was associated with higher risks of atrial septal defect, ventricular septal defect, and Tetralogy of Fallot. Maternal GDM may be associated with a higher risk of CHD in offspring.

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“… 1 Approximately 70,000 patients with congenital heart disease undergo annual surgical treatment. 2 All patients require postoperative care in the intensive care unit (ICU). Many factors affect postoperative recovery, and the level of infection prevention and control (IPC) is very important.…”

Section: Introductionmentioning

confidence: 99%

Nosocomial Infections After Pediatric Congenital Heart Disease Surgery: Data from National Center for Cardiovascular Diseases in China

Wang,

Li,

Huo

et al. 2024

IDR

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Purpose Infection prevention and control (IPC) has a significant impact on the prognosis after pediatric cardiac surgery. This study aimed to provide surveillance data on the incidence and density of various infections during the COVID-19 epidemic and explore the influence of multi-drug resistant organisms (MDRO) on in-hospital prognosis after congenital heart disease surgery. Methods This single-center retrospective study included pediatric patients who underwent cardiac surgery between 2021 and 2022. The results of the postoperative bacterial and fungal cultures and antimicrobial stewardship were collected. The demographic characteristics (age and weight), operation-related parameters (RACHS-1 grade, duration of cardiopulmonary bypass, and aortic cross clamp), and surgical outcomes (extracorporeal membrane oxygenation, delayed sternal closure, mortality, duration of mechanical ventilation, length of intensive care unit stay and hospital stay, and hospitalization costs) of MDRO and non-MDRO patients were compared. Results A total of 4776 patients were included. There were 101 infectious culture results after the operation, with a nosocomial infection rate of 2.1%. There were 40 MDRO specimens from 36 patients, 50 non-MDRO specimens from 30 patients, and 11 fungal specimens from 10 patients. The incidence of pneumonia was 1.5%, with a ventilator-associated pneumonia incidence density of 7.2/1000 patient-days. The incidence of sepsis was 0.4%, with a catheter-related bloodstream infection incidence density of 0.24/ 1000 patient-days. The incidence density of catheter-associated tract infection was 0.45/ 1000 patient-days. The incidence of surgical site infection was 0.06%. The culture proportion before commencing antibiotics was 93% and the antibiotic consumption intensity was 30.7 DDD/100 bed-days. The length of intensive care unit stay in MDRO infection patients increased compared with that in non-MDRO infection patients, 30 (18,52) vs 17 (7,62) days, p=0.05). Conclusion The IPC performance of Fuwai Hospital achieved satisfactory results. MDRO infection can lead to prolonged intensive care unit stay.

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Current treatment outcomes of congenital heart disease and future perspectives

Cited by 14 publications

References 71 publications

Failure to thrive in pediatric patients with congenital heart disease: a cross-sectional study of 13,256 patients

Failure to thrive in pediatric patients with congenital heart disease: a cross-sectional study of 13,256 patients

Maternal Gestational Diabetes Mellitus and Congenital Heart Disease in Offspring: A Meta-Analysis

Nosocomial Infections After Pediatric Congenital Heart Disease Surgery: Data from National Center for Cardiovascular Diseases in China

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