Current treatment methods to improve the bioactivity and bonding strength of PEEK for dental application: A systematic review

Ma, Tran; Zhang, Jiajia; Sun, Shuoyao; Meng, Weixiao; Zhang, Yan; Wu, Jianhua

doi:10.1016/j.eurpolymj.2022.111757

Cited by 14 publications

(8 citation statements)

References 137 publications

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“…Interestingly, ALP activity was also signicantly improved on hPEEK without BMP-2 loading compared to PEEK or PEEK/BMP2. Some studies have reported that introducing sulfonate groups onto titanium surface, 51,52 as well as PEEK surface, 45,53 signicantly increased the adhesion, spreading, proliferation, and osteogenic differentiation of osteoblasts or stem cells. Although no clear mechanism explaining why sulfonation enhanced osteoblast responses was elucidated, it might be associated with improved surface hydrophilicity aer sulfonation.…”

Section: 4mentioning

confidence: 99%

Chemically heparinized PEEK via a green method to immobilize bone morphogenetic protein-2 (BMP-2) for enhanced osteogenic activity

Goh,

Min,

Kim

et al. 2024

RSC Adv.

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Section: 4mentioning

confidence: 99%

Chemically heparinized PEEK via a green method to immobilize bone morphogenetic protein-2 (BMP-2) for enhanced osteogenic activity

Goh,

Min,

Kim

et al. 2024

RSC Adv.

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“…Beacuse of its anti-wear performance, it is used in knee and hip joint replacements [18]. It is a radiolucent polymer; therefore, the defects can be observed easily by x-ray compared to metal implants [19].…”

Section: Introductionmentioning

confidence: 99%

Methods to improve antibacterial properties of PEEK: A review

Uysal,

Tezcaner,

Evis

2024

Biomed. Mater.

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As a thermoplastic and bioinert polymer, polyether ether ketone (PEEK) serves as spine implants, femoral stems, cranial implants, and joint arthroplasty implants due to its mechanical properties resembling the cortical bone, chemical stability, and radiolucency. Although there are standards and antibiotic treatments for infection control during and after surgery, the infection risk is lowered but can not be eliminated. The antibacterial properties of PEEK implants should be improved to provide better infection control. This review includes the strategies for enhancing the antibacterial properties of PEEK in four categories: immobilization of functional materials and functional groups, forming nanocomposites, changing surface topography, and coating with antibacterial material. The measuring methods of antibacterial properties of the current studies of PEEK are explained in detail under quantitative, qualitative, and in vivo methods. The mechanisms of bacterial inhibition by reactive oxygen species (ROS) generation, contact killing, trap killing, and limited bacterial adhesion on hydrophobic surfaces are explained with corresponding antibacterial compounds or techniques. The prospective analysis of the current studies is done, and dual systems combining osteogenic and antibacterial agents immobilized on the surface of PEEK are found the promising solution for a better implant design.

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“…However, these surface treatment methods, such as ion implantation, were reported to be much more energetic and easily injured the surface of polymers such as PEEK ( Popok, 2019 ). Although the method of thermal spraying could endow the PEEK surface with a good biological effect, the prepared coating was usually reported to possess weak bonding with the PEEK substrate and easily peeled off ( Ma et al, 2023 ).…”

Section: Introductionmentioning

confidence: 99%

A self-assembling graphene oxide coating for enhanced bactericidal and osteogenic properties of poly-ether-ether-ketone

Huang,

Gu,

Yuan

et al. 2024

Front. Bioeng. Biotechnol.

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Poly-ether-ether-ketone (PEEK) is a biomedical plastic that can be used for orthopedic implants, but it offers poor antibacterial properties and bioactivity. In this study, PEEK was sulfonated with the obtained porous structure adsorbing graphene oxide (GO). The surface microstructures and properties of the original PEEK, sulfonated PEEK (SPEEK), and GO-grafted PEEK (GO-SPEEK) were characterized. The results revealed that the GO-SPEEK surface is a 3D porous structure exhibiting superior hydrophilicity to the original PEEK. Although SPEEK was shown to possess antimicrobial properties against both Escherichia coli and Staphylococcus aureus, the bactericidal effect was even more significant for GO-SPEEK, at about 86% and 94%, respectively. In addition, the in vitro simulated-body-fluid immersion and cell experiments indicated that GO-SPEEK had much better hydroxyapatite (HA)-precipitation induction capacity and cell–material interactions (e.g., cell adhesion, proliferation, osteodifferentiation, and extracellular matrix mineralization. The tensile test revealed that the mechanical properties of PEEK were maintained after surface modification, as GO-SPEEK has comparable values of elastic modulus and tensile strength to PEEK. Our investigation sought a method to simultaneously endow PEEK with both good antimicrobial properties and bioactivity as well as mechanical properties, providing a theoretical basis for developing high-performance orthopedic implants in the clinic.

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Current treatment methods to improve the bioactivity and bonding strength of PEEK for dental application: A systematic review

Cited by 14 publications

References 137 publications

Chemically heparinized PEEK via a green method to immobilize bone morphogenetic protein-2 (BMP-2) for enhanced osteogenic activity

Chemically heparinized PEEK via a green method to immobilize bone morphogenetic protein-2 (BMP-2) for enhanced osteogenic activity

Methods to improve antibacterial properties of PEEK: A review

A self-assembling graphene oxide coating for enhanced bactericidal and osteogenic properties of poly-ether-ether-ketone

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