2014
DOI: 10.1007/s00335-014-9549-4
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Current transcriptomics in pig immunity research

Abstract: Swine performance in the face of disease challenge is becoming progressively more important. To improve the pig's robustness and resilience against pathogens through selection, a better understanding of the genetic and epigenetic factors in the immune response is required. This review highlights results from the most recent transcriptome research, and the meta-analyses performed, in the context of pig immunity. A technological overview is given including wholegenome microarrays, immune-specific arrays, small-s… Show more

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Cited by 28 publications
(26 citation statements)
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References 171 publications
(118 reference statements)
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“…Changes in expression of combinations of smaller subsets of genes may be coordinated and detection of these changes as biomarkers of production disease could be of immense value in improved diagnosis and risk analysis to determine best practice with an impact on increased economic output and animal welfare. In the last ten years we have seen a rise in the number of publications using whole genome arrays to analyse the pig transcriptome which Schroyen and Tuggle, 2015 reviewed in greater detail (Schroyen and Tuggle, 2015). In particular, there has been a great deal of focus on the pig's immune system and the response to various pathogens such as PRRSV (Miller et al, 2012;Wilkinson et al, 2016).…”
Section: Introductionmentioning
confidence: 99%
“…Changes in expression of combinations of smaller subsets of genes may be coordinated and detection of these changes as biomarkers of production disease could be of immense value in improved diagnosis and risk analysis to determine best practice with an impact on increased economic output and animal welfare. In the last ten years we have seen a rise in the number of publications using whole genome arrays to analyse the pig transcriptome which Schroyen and Tuggle, 2015 reviewed in greater detail (Schroyen and Tuggle, 2015). In particular, there has been a great deal of focus on the pig's immune system and the response to various pathogens such as PRRSV (Miller et al, 2012;Wilkinson et al, 2016).…”
Section: Introductionmentioning
confidence: 99%
“…Blood constitutes a relevant tissue for phenotyping immune capacity (Flori et al, 2011;Mach et al, 2013;Schroyen and Tuggle, 2015), and evaluating the health status of pigs. To study the health status in piglets during the period after weaning, we conducted correlation analyses between the haematological traits collected at weaning (28 d) and one week after weaning (34 d), and the model parameter data.…”
Section: Applicability Of the Model In Porcine Productionmentioning
confidence: 99%
“…The domestic pig (Sus scrofa) is an important farm animal for meat source worldwide and has been used as alternative models for studying genetics, nutrition, and disease as reviewed recently (Houpt et al 1979; Verma et al 2011; Bailey and Carlson 2019). The swine genome community has created a large amount of useful data about the transcriptome of pigs (Schroyen and Tuggle 2015). The recently released pig genome sequence (Sscrofa 10.2) (Groenen et al 2012) and associated annotation greatly enhance our knowledge of the pig biology (Dawson et al 2013; Beiki et al 2019).…”
Section: Introductionmentioning
confidence: 99%
“…In the pig, several Expressed Sequence Tag (EST) sequencing projects, microarray platforms, and deep sequencing projects have developed gene expression profiles across a range of tissues (Hornshoj et al 2007; Freeman et al 2012). Compared to the model organisms, the information of the pig transcriptome is still limited in terms of comprehensive tissue and gene coverage (Schroyen and Tuggle 2015). Here we present Super deepSAGE (serial analysis of gene expression by deep sequencing) profiling data for the normal pig tissues with wide gene coverage and annotation.…”
Section: Introductionmentioning
confidence: 99%