Current therapeutic interventions in the glycation pathway: evidence from clinical studies

Engelen, L.; Stehouwer, Coen D. A.; Schalkwijk, Casper G.

doi:10.1111/dom.12058

Cited by 105 publications

(90 citation statements)

References 163 publications

(220 reference statements)

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“…2e). Low thiamine blood levels have been linked to complications of T1DM 48 and colonic uptake transporters of thiamine have been described 49 . However, the observed patterns in transcript abundances of thiazole synthase and plasma thiamine levels were not correlated in the small subset of individuals who did not take thiamine supplements, precluding any conclusions (Supplementary Section 18 and Supplementary Fig.…”

Section: Human Protein Excretion In T1dm and Microbial Functionsmentioning

confidence: 99%

Integrated multi-omics of the human gut microbiome in a case study of familial type 1 diabetes

et al. 2016

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The gastrointestinal microbiome is a complex ecosystem with functions that shape human health. Studying the relationship between taxonomic alterations and functional repercussions linked to disease remains challenging. Here, we present an integrative approach to resolve the taxonomic and functional attributes of gastrointestinal microbiota at the metagenomic, metatranscriptomic and metaproteomic levels. We apply our methods to samples from four families with multiple cases of type 1 diabetes mellitus (T1DM). Analysis of intra-and inter-individual variation demonstrates that family membership has a pronounced effect on the structural and functional composition of the gastrointestinal microbiome. In the context of T1DM, consistent taxonomic differences were absent across families, but certain human exocrine pancreatic proteins were found at lower levels. The associated microbial functional signatures were linked to metabolic traits in distinct taxa. The methodologies and results provide a foundation for future large-scale integrated multi-omic analyses of the gastrointestinal microbiome in the context of host-microbe interactions in human health and disease.

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Section: Human Protein Excretion In T1dm and Microbial Functionsmentioning

confidence: 99%

Integrated multi-omics of the human gut microbiome in a case study of familial type 1 diabetes

et al. 2016

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“…Indeed, it has been shown that alagebrium is able to reduce large artery stiffening in animal models. 36 One double-blind randomized controlled trial correspondingly showed a decrease in pulse pressure and cfPWV in individuals who received alagebrium. 37 However, another double-blind randomized controlled trial Figure. Associations between measures of advanced glycation end product (AGE) accumulation and carotid to femoral pulse-wave velocity (cfPWV) or central pulse pressure (cPP) in individuals with normal glucose metabolism (NGM), impaired glucose metabolism (IGM), and type 2 diabetes mellitus (T2DM).…”

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confidence: 99%

Skin Autofluorescence and Pentosidine Are Associated With Aortic Stiffening

et al. 2016

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Abstract-Arterial stiffening, as characterized by an increase in carotid-femoral pulse-wave velocity or pulse pressure, increases the risk of cardiovascular disease, especially among individuals with type 2 diabetes mellitus. Advanced glycation end products are hypothesized to play a role in the development of arterial stiffness. Therefore, we investigated the association between skin autofluorescence, an estimate of tissue advanced glycation end products, and plasma advanced glycation end products on the one hand and arterial stiffening on the other in 862 participants of The Maastricht Study (mean age of 60 years; 45% women) with normal glucose metabolism (n=469), impaired glucose metabolism (n=140), or type 2 diabetes (n=253). Associations were analyzed with linear regression analysis and adjusted for potential confounders. We found that higher skin autofluorescence as measured by the AGE Reader and plasma pentosidine were independently associated with higher carotid-femoral pulse-wave velocity (sβ 0.10; 95% confidence interval, 0.03-0.17 and 0.10; 0.04-0.16, respectively) and central pulse pressure (sβ 0.08; 95% confidence interval 0.01-0.15 and 0.07; 0.01-0.13, respectively). The associations between skin autofluorescence and pentosidine, and carotid-femoral pulsewave velocity were more pronounced in individuals with type 2 diabetes mellitus (P-interaction<0.10). These results support the hypothesis that accumulation of advanced glycation end products is involved in arterial stiffening and may explain part of the increased risk of cardiovascular disease in individuals with type 2 diabetes mellitus. carotid to femoral pulse-wave velocity (cfPWV) or pulse pressure, both measures of aortic stiffening, in a population-based setting, including individuals with normal glucose metabolism (NGM), impaired glucose metabolism (IGM), and T2DM. In view of these considerations, the aims of our study were, first, to evaluate the independent association between SAF and plasma AGEs on the one hand and measures of arterial stiffening, ie, cfPWV, central pulse pressure, and 24-hour ambulatory pulse pressure, on the other. Second, to examine whether these associations differed between individuals with NGM, IGM, or T2DM. Methods Study Population and DesignIn this study, we used data from The Maastricht Study, an observational prospective population-based cohort study. The rationale and methodology have been described previously. 22 In brief, the study focuses on the cause, pathophysiology, complications, and comorbidities of type 2 diabetes mellitus (T2DM) and is characterized by an extensive phenotyping approach. Eligible for participation were all individuals aged between 40 and 75 years and living in the southern part of the Netherlands. Participants were recruited through mass media campaigns and from the municipal registries and the regional Diabetes Patient Registry via mailings. Recruitment was stratified according to known T2DM status for reasons of efficiency. The present report includes cross-sectional data from the ...

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“…[42][43][44] As GNPs can be used in vivo and can be readily prepared, a deeper understanding of their antiglycation potential may lead to novel therapeutic approaches for treating diseases whose complications relate to the formation of AGEs.…”

Section: Discussionmentioning

confidence: 99%

Inhibitory effect of gold nanoparticles on the D-ribose glycation of bovine serum albumin

Liu¹,

Cohenford²,

Frost³

et al. 2014

IJN

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Formation of advanced glycation end products (AGEs) by nonenzymatic glycation of proteins is a major contributory factor to the pathophysiology of diabetic conditions including senile dementia and atherosclerosis. This study describes the inhibitory effect of gold nanoparticles (GNPs) on the D-ribose glycation of bovine serum albumin (BSA). A combination of analytical methods including ultraviolet–visible spectrometry, high performance liquid chromatography, circular dichroism, and matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry were used to determine the extent of BSA glycation in the presence of citrate reduced spherical GNPs of various sizes and concentrations. GNPs of particle diameters ranging from 2 nm to 20 nm inhibited BSA’s AGE formation. The extent of inhibition correlated with the total surface area of the nanoparticles. GNPs of highest total surface area yielded the most inhibition whereas those with the lowest total surface area inhibited the formation of AGEs the least. Additionally, when GNPs’ total surface areas were set the same, their antiglycation activities were similar. This inhibitory effect of GNPs on BSA’s glycation by D-ribose suggests that colloidal particles may have a therapeutic application for the treatment of diabetes and conditions that promote hyperglycemia.

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Current therapeutic interventions in the glycation pathway: evidence from clinical studies

Cited by 105 publications

References 163 publications

Integrated multi-omics of the human gut microbiome in a case study of familial type 1 diabetes

Integrated multi-omics of the human gut microbiome in a case study of familial type 1 diabetes

Skin Autofluorescence and Pentosidine Are Associated With Aortic Stiffening

Inhibitory effect of gold nanoparticles on the D-ribose glycation of bovine serum albumin

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