Current Surgical Therapy of Locally Advanced cSCC: From Patient Selection to Microsurgical Tissue Transplant. Review

Brambullo, Tito; Azzena, Gian Paolo; Toninello, Paolo; Masciopinto, Giuseppe; Lazzari, Alberto De; Biffoli, Bernardo; Vindigni, Vincenzo; Bassetto, Franco

doi:10.3389/fonc.2021.783257

Cited by 4 publications

(6 citation statements)

References 106 publications

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“…Although the standard of care remains tumor excision with clear margins, the reconstructive process may be challenging in cases of locally advanced neoplasms [38]. This may imply that the risk of secondary complications could overweigh the benefits of the surgery, and if the second step cannot be successfully accomplished, maybe the entire procedure should be abandoned in favor of other non-surgical treatments.…”

Section: Discussionmentioning

confidence: 99%

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A Misdiagnosed Familiar Brooke–Spiegler Syndrome: Case Report and Review of the Literature

Brambullo,

De Lazzari,

Franchi

et al. 2024

JCM

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Aim of the report: Brooke–Spiegler syndrome (BSS) is a rare autosomal dominant disease characterized by the growth of cylindromas, spiradenomas, trichoepitheliomas, or their combination. These neoplasms usually begin in the second decade and progressively increase in number and size over the years. Diagnosis necessitates consideration of family history, clinical examination, histological findings, and genetic analysis. The aim of this paper is to explore the clinical overlap between Brooke–Spiegler syndrome (BSS) and neurofibromatosis type 1 (NF1). We aim to highlight the challenges associated with their differential diagnosis and emphasize the lack of standardized diagnostic criteria and treatment approaches. Case presentation: Hereby, we introduce the case of a 28-year-old male referred for suspicion of neurofibromatosis type 1 (NF1) who initially declined the recommended surgical excision for a scalp mass. After four years, he returned with larger masses of the scalp, and underwent excision of multiple masses, revealing cylindromas, spiradenomas, and spiradenocylindromas. Family history reported similar tumors in his father, who was also diagnosed with NF1 for the presence of multiple subcutaneous lesions on the scalp. Clinical overlap led to a genetic consultation, but testing for CYLD mutations yielded no significant variations. Despite this, the strong family history and consistent findings led to a revised diagnosis of Brooke–Spiegler syndrome, correcting the initial misdiagnosis of NF1 syndrome. Conclusions: Thanks to the evolving landscape of BSS research over the past two decades, its molecular underpinnings, clinical presentation, and histopathological features are now clearer. However, a thorough family history assessment is mandatory when BSS is suspected. It is our belief that a multidisciplinary approach and cooperation between specialists are essential when dealing with BSS. By sharing this case, we hope to underscore the importance of considering BSS as a differential diagnosis, especially in cases with atypical presentations or overlapping features with other syndromes like NF1.

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Section: Discussionmentioning

confidence: 99%

“…For all the above-mentioned reasons, surgeons find the MTB to be particularly beneficial when dealing with complex and advanced cases [38].…”

Section: Discussionmentioning

confidence: 99%

A Misdiagnosed Familiar Brooke–Spiegler Syndrome: Case Report and Review of the Literature

Brambullo,

De Lazzari,

Franchi

et al. 2024

JCM

Self Cite

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“…Different from the study by Chen et al that observed a significant increase in treatment costs in the advanced stages of the disease, we observed an approximately 4-fold increase in the treatment costs of stage IV compared with stage I, but our results had no statistical significance [ 15 ]. However, the costs may be related to the more complex surgical procedure and to the more careful postoperative medical attention in advanced stages compared to early stages [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

The Prevalence and Treatment Costs of Non-Melanoma Skin Cancer in Cluj-Napoca Maxillofacial Center

et al. 2023

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Background and Objectives: An increasing incidence of non-melanoma skin cancer (NMSC) is noted, as well as an increasing cost of the treatment, with NMSC becoming a public health problem. We aimed to investigate the prevalence and treatment costs of surgically treated NMSC from the Oral and Maxillofacial Surgery Department of Cluj-Napoca County Hospital. Materials and Methods: We retrospectively analyzed the clinical data and the charge data of hospitalization from the informatic system of Cluj-Napoca County Hospital. All patients benefited from standard surgical excision with the reconstruction of the post-excisional defect. A statistical analysis of the costs related to the patients’ features, period and conditions of hospitalization, materials, medication, and paraclinical investigations was performed. Results: Between 2015 and 2019, 133 patients with NMSC were addressed to our department, with basal cell carcinoma (BCC) being four-fold higher than squamous cell carcinoma (SCC). Most NMSC cases were diagnosed in stage I or II, and they benefited from local reconstruction. The treatment costs progressively increased in the last five years, reaching a total cost of EUR ~13.000 in 2019. The treatment cost per episode was higher for SCC compared to BCC, while the total cost of treatment in 5 years was higher for BCC. Low income, immunosuppression, comorbidities, flap reconstruction option, long-lasting surgery, and prolonged hospitalization were associated with an increased cost of the treatment. Conclusion: The prevalence and treatment cost of surgically treated NMSC of the head and neck region increased in the last five years, with high-cost drivers being related to patients and treatment options.

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“…Flap surgery is commonly employed for wound repair or tissue transplantation, 7 with the key objective of ensuring flap viability. To achieve optimal surgical outcomes, it is crucial to preoperatively select the most suitable vascular pedicle for blood supply 8 . IRT can provide thermal distribution images of blood vessels, revealing temperature variations in different regions 9 .…”

Section: Introductionmentioning

confidence: 99%

“…To achieve optimal surgical outcomes, it is crucial to preoperatively select the most suitable vascular pedicle for blood supply. 8 IRT can provide thermal distribution images of blood vessels, revealing temperature variations in different regions. 9 Generally, areas with larger vessel diameters and faster blood flow tend to exhibit higher surface temperatures.…”

Section: Introductionmentioning

confidence: 99%

The application of infrared thermography technology in flap: A perspective from bibliometric and visual analysis

Sun

et al. 2023

International Wound Journal

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The application of infrared thermography technology (IRT) in flap has become a major focus of research, as it provides a non‐invasive, real‐time, and quantitative approach for monitoring flap perfusion. In this regard, we conducted a comprehensive visualization and scientometric analysis to systematically summarize and discuss the current state of research in this field. We systematically reviewed publications on the application of IRT in flap procedures from 1999 to 2022, using the Web of Science Core Collection (WoSCC). Through scientometric analysis, we examined annual trends, affiliations, countries, journals, authors, and their relationships, providing insights into current hotspots and future developments in this area. We analysed 522 English studies and found a steady increase in annual publications. The United States and Germany had the highest publication rates, with Beth Israel Deaconess Medical Center and Shanghai Jiaotong University being leading institutions. Notably, Lee BT and Alex Keller emerged as influential authors in this field. Compared to existing techniques, infrared‐based technology offers significant advantages for non‐invasive monitoring of flap perfusion, including simplicity of operation and objective results. Future trends should focus on interdisciplinary collaborations to develop new infrared devices and achieve intelligent image processing, enabling broader application in various clinical scenarios. This bibliometric study summarizes the progress and landscape of research on ‘the Application of infrared thermography technology in flap’ over the past two decades, providing valuable insights and serving as a reliable reference to drive further advancements and spark researchers' interest in this field.

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Current Surgical Therapy of Locally Advanced cSCC: From Patient Selection to Microsurgical Tissue Transplant. Review

Cited by 4 publications

References 106 publications

A Misdiagnosed Familiar Brooke–Spiegler Syndrome: Case Report and Review of the Literature

A Misdiagnosed Familiar Brooke–Spiegler Syndrome: Case Report and Review of the Literature

The Prevalence and Treatment Costs of Non-Melanoma Skin Cancer in Cluj-Napoca Maxillofacial Center

The application of infrared thermography technology in flap: A perspective from bibliometric and visual analysis

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