Current Success and Efficiency of Autologous Ovarian Transplantation: A Meta-Analysis

Pacheco, Fernanda; Oktay, Kutluk

doi:10.1177/1933719117702251

Cited by 192 publications

(146 citation statements)

References 51 publications

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“…21,22 Recent studies also have demonstrated the effectiveness of the technique in patients who have previously undergone chemotherapy, opening FP options to select patients between cycles and after treatment. Laparoscopic unilateral oophorectomy (partial or complete) is the preferred surgical technique.…”

Section: Ovarian Tissue Cryopreservationmentioning

confidence: 99%

“…24 Although slow-freeze techniques for cryopreservation currently are the standard, initial data from more recent studies have shown vitrification (rapid freeze) to be at least comparable if not favored. 21,23,[25][26][27] To the best of our knowledge, all live births to date have used orthotopic transplantation without specific data available regarding the ideal orthotopic location. 20 Studies also have demonstrated successful pregnancies in patients with ovarian tissue specimens that were transported overnight (up to 20 hours) prior to cryopreservation.…”

Section: Ovarian Tissue Cryopreservationmentioning

confidence: 99%

“…More data are needed because the majority of reproductive centers currently use vitrification techniques for oocyte/embryo cryopreservation and may more easily integrate OTC with similar processing. 21 To our knowledge, to date there have been >130 live births and several ongoing pregnancies from OTT, mostly from patients who were adult women at the time of cryopreservation. 25 Ovarian tissue transplantation (OTT) is the process of thawing and then surgically returning the ovarian cortical strips to patients.…”

Section: Ovarian Tissue Cryopreservationmentioning

confidence: 99%

See 2 more Smart Citations

Fertility preservation options in pediatric and adolescent patients with cancer

Burns

Hoefgen

Strine

et al. 2018

Cancer

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The incidence of childhood cancer has steadily increased since the 1950s, with approximately 16,000 children diagnosed each year. However, with the advent of more effective multimodal therapies, childhood cancer survival rates have continued to improve over the past 40 years, with >80% of patients now surviving into adulthood. Fertility preservation (FP) has become an important quality-of-life issue for many survivors of childhood cancer. As a result, the therapeutic options have become less gonadotoxic over time and more patients are being offered FP options. This review examines the indications for consultation, male and female FP options both in the prepubertal patient and adolescent patient, and the unique ethical issues surrounding FP in this vulnerable population. Cancer 2018;124:1867-76. © 2018 American Cancer Society.

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Section: Ovarian Tissue Cryopreservationmentioning

confidence: 99%

Section: Ovarian Tissue Cryopreservationmentioning

confidence: 99%

Section: Ovarian Tissue Cryopreservationmentioning

confidence: 99%

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Fertility preservation options in pediatric and adolescent patients with cancer

Burns

Hoefgen

Strine

et al. 2018

Cancer

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“…The potential of the stored ovarian tissue to support fertility restoration when the individual wishes to start her family is demonstrated by the delivery of more than 130 healthy babies world wide after autotransplantation of the frozen-thawed tissue and the restoration of endocrine and ovarian function (Pacheco and Oktay, 2017) with more ongoing pregnancies being recorded. Although the overall efficiency of fertility restoration following ovarian tissue preservation and transplantation is unknown, recent evidence from defined cohorts of patients suggests a ~30% live birth rate after autotransplantation of slow frozen-thawed ovarian cortex, (Jadoul et al, 2017;Keden et al, 2018).…”

Section: Ovarian Tissue Preservationmentioning

confidence: 99%

Preservation of female fertility in humans and animal species

Picton¹

2018

Anim Reprod

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A detailed understanding of the cryobiology of gametes and complex tissues has led to the development of methods that facilitate the successful low temperature banking of isolated mature human oocytes, or immature oocytes in situ within fragments of human ovarian cortex. Although many outstanding research challenges remain to be addressed, the successful development of new treatments to preserve female fertility for a range of clinical indications has largely been underpinned by the conduct of extensive, fundamental research on oocytes and ovarian tissues from a number of laboratory and commercially important farm species. Indeed, the most recent evidence from large animals suggests that it is also possible to cryopreserve intact whole ovaries along with their supporting vasculature for later autotransplantation and restoration of natural fertility. This review will explore how the methods developed to preserve human oocytes and ovarian tissues can now be used strategically to support the development of conservation strategies aimed at safeguarding the genetic diversity of commercially important domestic animals and also of preserving the female germplasm for wild animals and endangered species.

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“…When followed by autotransplantation, success rates are high regarding the reestablishment of ovarian activity (63.9%) and natural live births (57.5%), according to a meta-analysis performed in 2017 [12]. …”

Section: Indications For Otcmentioning

confidence: 99%

Cryopreservation of Human Ovarian Tissue: A Review

Leonel

Lucci

Amorim

2019

Transfus Med Hemother

117

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Background: Cryopreservation of human ovarian tissue has been increasingly applied worldwide to safeguard fertility in cancer patients, notably in young girls and women who cannot delay the onset of their treatment. Moreover, it has been proposed to patients with benign pathologies with a risk of premature ovarian insufficiency. So far, more than 130 live births have been reported after transplantation of cryopreserved ovarian tissue, and almost all patients recovered their ovarian function after tissue reimplantation. Summary: This review aims to summarize the recent results described in the literature regarding human ovarian tissue cryopreservation in terms of methods and main results obtained so far. To cryopreserve human ovarian tissue, most studies describe a slow freezing/rapid thawing protocol, which is usually an adaptation of a protocol developed for sheep ovarian tissue. Since freezing has been shown to have a deleterious effect on ovarian stroma and granulosa cells, various research groups have been vitrifying ovarian tissue. Despite promising results, only 2 babies have been born after transplantation of vitrified/warmed ovarian tissue. Optimization of both cryopreservation strategies as well as thawing/warming protocols is therefore necessary to improve the survival of follicles in cryopreserved ovarian tissue. Key Messages: Human ovarian tissue cryopreservation has been successfully applied worldwide to preserve fertility in patients with malignant or nonmalignant pathologies that have a detrimental effect on fertility. Human ovarian tissue cryopreservation could also be applied as an alternative to postpone pregnancy or menopause in healthy women. Slow freezing and vitrification procedures have been applied to cryopreserve human ovarian tissue, but both alternatives require optimization.

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Current Success and Efficiency of Autologous Ovarian Transplantation: A Meta-Analysis

Abstract: Success rates with cryopreserved OTT have reached promising levels. Given these recent data, ovarian tissue cryopreservation should be considered as a viable option for FP.

Cited by 192 publications

References 51 publications

Fertility preservation options in pediatric and adolescent patients with cancer

Fertility preservation options in pediatric and adolescent patients with cancer

Preservation of female fertility in humans and animal species

Cryopreservation of Human Ovarian Tissue: A Review

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