Current strategies towards hemocompatible coatings

Werner, Carsten; Maitz, Manfred F.; Sperling, Claudia

doi:10.1039/b703416b

Cited by 240 publications

(214 citation statements)

References 165 publications

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“…Hydrophobic surfaces (for example, ePTFE, which is a porous perfluorinated solid material) are clinically approved as vascular grafts 36 ; however, these fail to improve the performance of medical devices 37 because they contain trapped air that can be thrombogenic 5,38 . To our knowledge, there is no other known medical material coating that can effectively suppress occlusive thrombosis in vivo under high pressure and high shear arterial flow in the complete absence of heparin.…”

Section: Discussionmentioning

confidence: 99%

“…Cleavage of fibrinogen to fibrin leads to the formation of polymerized fibrin networks that form the backbone of the clot, which becomes intertwined with aggregates of platelets that are simultaneously activated by either interacting directly with the material surface or with surface-bound proteins 5 . We exposed smooth plastic surfaces to fresh, whole human blood containing a low dose of heparin (0.25 U/ml) because otherwise clotting would initiate immediately.…”

Section: Reduced Adhesion and Activation Of Fibrinogen And Plateletsmentioning

confidence: 99%

“…However, the need to co-administer soluble anticoagulant drugs, such as heparin, with many of these procedures, significantly reduces their safety and hampers their effectiveness 3,4 . Without systemic anticoagulation, these extracorporeal and indwelling devices can rapidly occlude due to thrombosis because clots form when fibrin and platelets in the flowing blood adhere to the surfaces of these artificial materials 5 . Unfortunately, heparin causes significant morbidity and mortality including post-operative bleeding, thrombocytopenia, hypertriglyceridemia, hyperkalemia and hypersensitivity 6 , and its use is contraindicated in several patient populations 7 .…”

Section: ____________________________________________________________mentioning

confidence: 99%

“…The TLP coating more closely resembles silicone liquid thin films previously used in vitro to delineate blood coagulation mechanisms without anticoagulants for short durations 34 . However, this surface did not prevent platelet adhesion or activation 35 , and it has not been shown to reduce thrombosis in vivo.Hydrophobic surfaces (for example, ePTFE, which is a porous perfluorinated solid material) are clinically approved as vascular grafts 36 ; however, these fail to improve the performance of medical devices 37 because they contain trapped air that can be thrombogenic 5,38 . To our knowledge, there is no other known medical material coating that can effectively suppress occlusive thrombosis in vivo under high pressure and high shear arterial flow in the complete absence of heparin.…”

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confidence: 99%

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A bioinspired omniphobic surface coating on medical devices prevents thrombosis and biofouling

et al. 2014

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________________________________________________________________Countless lives have been saved by implantable medical devices (e.g., total artificial hearts, ventricular assist devices, pacemakers, cardioverterdefibrillators, and central lines) and extracorporeal devices that flow whole human blood outside the body through indwelling catheters and external circuits, during cardiopulmonary bypass (CPB), hemodialysis, and extracorporeal membrane oxygenation (ECMO) 1,2 . However, the need to co-administer soluble anticoagulant drugs, such as heparin, with many of these procedures, significantly reduces their safety and hampers their effectiveness 3,4 . Without systemic anticoagulation, these extracorporeal and indwelling devices can rapidly occlude due to thrombosis because clots form when fibrin and platelets in the flowing blood adhere to the surfaces of these artificial materials 5 . Unfortunately, heparin causes significant morbidity and mortality including post-operative bleeding, thrombocytopenia, hypertriglyceridemia, hyperkalemia and hypersensitivity 6 , and its use is contraindicated in several patient populations 7 . In fact, the majority of drug-related deaths from adverse clinical events in the UnitedStates are due to systemic anticoagulation 8 .This need to prevent blood clotting while minimizing administration of anticoagulant drugs has led to the search for biomaterial surface coatings that can directly suppress blood clot formation. The most successful approach to date has been to chemically immobilize heparin on blood-contacting surfaces to reduce thrombosis and lower anticoagulant administration 9,10 . Although this approach has been widely adopted, major limitations persist because the surface-bound heparin leaches, resulting in a progressive loss of anticoagulation 24,25 . Importantly, the TP continues to retain the free LP as a thin mobile liquid layer even when the surface is challenged with a flowing immiscible fluid, such as blood (Fig. 1a). We refer to this unique anti-thrombogenic bilayer composed of the TP and LP coating as a Tethered-Liquid Perfluorocarbon (TLP) surface. RESULTS A generic blood repellent surface coatingTo test the anti-adhesive properties of the TLP coating method, we examined surface adhesion of fresh whole human blood on an acrylic surface sloped at an angle of 30 degrees, with or without a TLP coating composed of tethered perfluorohexane and liquid perfluorodecalin. Blood droplets immediately adhered to the control uncoated acrylic surface and left a trail of blood components over the course of 5 sec (Fig. 1b, top, Supplementary Fig. 1 and Supplementary Movie 1).In contrast, when the same surface was coated with TLP, the blood droplet almost immediately slid off the surface (< 0.3 sec), and remarkably, there was no evidence of any residual blood trail (Fig. 1b, Supplementary Fig. 1 and Supplementary Movie 2). We quantified blood adhesion to surfaces by measuring the minimum angle required to cause a droplet to slide ("sliding angle") ( Fig. 1c). Control uncoated s...

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Section: Discussionmentioning

confidence: 99%

Section: Reduced Adhesion and Activation Of Fibrinogen And Plateletsmentioning

confidence: 99%

Section: ____________________________________________________________mentioning

confidence: 99%

mentioning

confidence: 99%

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A bioinspired omniphobic surface coating on medical devices prevents thrombosis and biofouling

et al. 2014

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“…1 In order to get blood compatible surfaces, many studies focused on surface modification by imitating the endothelial surface layer (ESL). [2][3][4][5][6][7][8][9][10] The ESL is a three dimensional network composed of biomolecules lining the luminal surface of endothelial cells. [11][12][13] It is highly hydrated and forms a protective mechanical interface for the blood vessels and prevents adsorption of blood cells and other plasma molecules.…”

Section: Introductionmentioning

confidence: 99%

Theoretical and experimental study of the porous film using quartz crystal microbalance

Zhang

Tian

et al. 2016

Biomicrofluidics

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The self-assembled multilayers have been studied by many researchers to modify the surfaces of artificial implants for increasing biocompatibility. The accurate mechanical properties of the film can only be obtained from the experimental results using appropriate theoretical models. As the film is composed of both solid polymers and fluid, this paper proposes a two-phase model. Based on the volume average method, the momentum equations are derived for both solid and liquid phases. In order to test our model, we built the porous film on the gold chip of the quartz crystal microbalance using the layer-by-layer method. The buildup process is based on the electrostatic interactions between anionic sodium hyaluronate and cationic chitosan by imitating the endothelial surface layer. By fitting our model to the experimental changes of the resonant frequency and dissipation factor, we get reasonable values of the film thickness, the porosity, the shear modulus of the solid phase, and the permeability. Compared with the existing models, the newly introduced permeability is an important property of the porous layer affecting the values of other parameters. Our model can provide more intrinsic properties of the selfassembled polymeric network and explain its interaction with the permeating fluid. Published by AIP Publishing. [http://dx

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Poly(2‐oxazoline)s

Verbraeken

Lava

Hoogenboom

2014

Encyclopedia of Polymer Science and Technology

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Research in the field of poly(2‐oxazoline)s (PAOx) is rapidly expanding as this polymer class combines high synthetic versatility and biocompatibility, opening up the way to highly functional (biocompatible) materials. PAOx are prepared by living cationic ring‐opening polymerization (CROP) of 2‐oxazolines. The variety of 2‐oxazoline monomers that are readily available or can easily be synthesized allows for tuning of polymer properties and introduction of diverse functionalities. Moreover, thanks to the living nature of CROP, well‐defined polymers with narrow molar mass distribution and high end group fidelity can be obtained. This article covers all aspects of PAOx ranging from the synthesis of 2‐oxazoline monomers, via in‐depth discussion on the CROP mechanism to the synthesis and properties of functional PAOx (co)polymers. The presented research demonstrates that owing to their structural adaptability and the so‐called “stealth” behavior, PAOx are well suited for a range of biomedical applications, including polymer therapeutics, scaffolds for three‐dimensional cell culture, surface modification, matrix excipient for solid dispersions, and antimicrobial agents.

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Current strategies towards hemocompatible coatings

Cited by 240 publications

References 165 publications

A bioinspired omniphobic surface coating on medical devices prevents thrombosis and biofouling

A bioinspired omniphobic surface coating on medical devices prevents thrombosis and biofouling

Theoretical and experimental study of the porous film using quartz crystal microbalance

Poly(2‐oxazoline)s

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