Current status on performance of CT colonography and clinical indications

Laghi, Andréa; Rengo, Marco; Graser, Anno; Iafrate, Franco

doi:10.1016/j.ejrad.2012.05.026

Cited by 32 publications

(17 citation statements)

References 96 publications

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“…Fourth, the superiority of CCE appears mainly to be related with a higher accuracy for small and/or non-polypoid lesions (table 4). This is in line with the suboptimal sensitivity of CTC for such lesions already shown in previous head-to-head CTC colonoscopy series 16 17 18 34–44. Of note, a more accelerated pathway towards cancer progression has been advocated for these lesions.…”

Section: Discussionsupporting

confidence: 88%

“…Exclusion criteria were those previously reported for small bowel capsule enteroscopy, CCE and CTC 23 24 25 28 17. In detail, patients with dysphagia or any swallowing disorder, congestive heart failure, renal insufficiency, prior abdominal surgery of the gastrointestinal tract (other than uncomplicated procedures that would be unlikely to lead to bowel obstruction), cardiac pacemaker or other implanted electromedical device, allergy or other known contraindication to the medications used in the study; patients expected to undergo MRI examination within 7 days after ingestion of the capsule, with any condition believed to have an increased risk for capsule retention (such as Crohn's disease, intestinal tumours, radiation enteritis, or non-steroidal anti-inflammatory drugs enteropathy), women either pregnant or nursing at the time of screening, who intended to be pregnant during the study period, or were of childbearing potential and were not practicing medically acceptable methods of contraception.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Colon capsule versus CT colonography in patients with incomplete colonoscopy: a prospective, comparative trial

Spada

Hassan

Barbaro³

et al. 2014

Gut

Self Cite

110

108

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Section: Discussionsupporting

confidence: 88%

Section: Methodsmentioning

confidence: 99%

Colon capsule versus CT colonography in patients with incomplete colonoscopy: a prospective, comparative trial

Spada

Hassan

Barbaro³

et al. 2014

Gut

Self Cite

110

108

View full text Add to dashboard Cite

show abstract

“…In addition to this 2 left sided cancers was confirmed endoscopically. Conclusion In this small cohort CTC seems comparable to colonoscopy for detection of polyps and cancers 1 .In the patient group selected almost 44% of cases thought to have significant comorbidity who had primary CTC ended up having a lower GI endoscopy along with a need for therapy. It is also noted that the majority of significant polyps and all cancers were located in the left colon.…”

Section: Pth-017mentioning

confidence: 99%

PTH-016 Defecating Scintigraphic Photography at St George’S Hospital: Review of Findings and Correlation with Patient Symptoms

Rusu

Beharry

Irwin³

et al. 2013

Gut

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BSG abstractsand endoscopic investigations performed up to 5 years previously were reviewed. Episodes of negative investigations were considered 'missed' opportunities for diagnosis. Clinical outcomes were compared using chi-squared test and Kaplan-Meier survival curves. Results 396 colorectal cancers were identified with 214 (54%) males and median age 72. Of these, 29 (7%) patients had undergone negative investigations including colonoscopy (n = 8), flexible sigmoidoscopy (n = 7), barium enema (n = 7) and CT for abdominal symptoms (n = 20) ('missed' group) within the previous 5 years, median 817 days prior to diagnosis. Age, mode of presentation, tumour site, pT and pN stage were comparable between groups. Metastases at presentation were more common in the 'missed' group (28% vs. 14%, p = 0.046) and survival at median follow-up of 416 days was significantly reduced (66% vs. 88%, p = 0.0004). Conclusion A small proportion (7%) of patients with colorectal cancer has undergone previous negative abdominal or colonic investigation. Such episodes may represent missed opportunities for diagnosis and survival is significantly reduced in such patients. The recognition that endoscopic and radiological investigations may miss lesions should encourage repeat or alternative interval investigations where concerning symptoms exist. Disclosure of Interest None Declared. Introduction Studies have reported a high prevalence of lower gastrointestinal (LGI) symptoms in bowel cancer screening (BCSP) patients. However, symptoms are often vague and without characterisation their significance is unclear. This study investigates the prevalence and characteristics of lower gastrointestinal symptoms in screening patients and aims to determine the relevance of two week wait (2ww) symptoms in this cohort. Methods A prospective cohort study was performed. BCSP patients presenting for colonoscopy over a 7-month period were included. Data on symptom prevalence, frequency and duration was collected and assessed against 2-week wait criteria. Associations between symptom prevalence and outcome were investigated using the two-tailed χ 2 test. Results Symptom and outcome data was collected in 397 patients. TWO WEEK WAIT SYMPTOMS ARE PREVALENT IN BOWEL CANCER SCREENING PATIENTS WITH A POSITIVE FAECAL OCCULT BLOOD TEST BUT DO NOT PREDICT CANCERLGI symptoms were reported by 282 (71%) patients and 37 patients (9%) were found to have colorectal cancer (CRC). Symptom prevalence was comparable between those with or without CRC (65% vs.72%, p = 0.473). Meanwhile, 2ww symptoms were reported in 148 (37%) of all patients. 2ww symptom prevalence was comparable in those with and without cancer (38% vs. 39%, p = 0.915). Conclusion This study demonstrates that while 2ww symptoms are highly prevalent in a FOB positive cohort, they do not predict a finding of colorectal cancer. These findings suggest that 2ww symptoms could not be used to prioritise investigation in this cohort while in those patients referred with 2ww symptoms, additional FOB testing would offer ...

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“…The most widely accepted CT technique for large bowel evaluation is CT-colonography with air or carbon dioxide [6][7][8][9] but the colonic distension may also be obtained using water as intraluminal contrast media. This technique, called E-CT with water enema (ECT-WE), is based on colonic distension with water and it offers an excellent visualization of the colonic wall due to parietal enhancement by iodine contrast, as well as a good contrast between wall, water-filled lumen and pericolic fat [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Enterography CT without and with water enema in patients with Crohn’s disease: Results from a comparative observational study in comparison with endoscopy

Minordi

Scaldaferri

Marra

et al. 2016

European Journal of Radiology

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Current status on performance of CT colonography and clinical indications

Cited by 32 publications

References 96 publications

Colon capsule versus CT colonography in patients with incomplete colonoscopy: a prospective, comparative trial

Colon capsule versus CT colonography in patients with incomplete colonoscopy: a prospective, comparative trial

PTH-016 Defecating Scintigraphic Photography at St George’S Hospital: Review of Findings and Correlation with Patient Symptoms

Enterography CT without and with water enema in patients with Crohn’s disease: Results from a comparative observational study in comparison with endoscopy

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