Current status on clinical applications of magnesium-based orthopaedic implants: A review from clinical translational perspective

Zhao, Dewei; Witte, Frank; Lu, Fangfang; Wang, Jiali; Li, Junlei; Qin, Ling

doi:10.1016/j.biomaterials.2016.10.017

Cited by 740 publications

(456 citation statements)

References 111 publications

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“…Lambotte also used pure Mg nails alone to fix supracondylar fractures of four children. He observed the formation of gas cavities due to the high corrosion rate of magnesium in vivo [37]. Mainly, because of this problem, the application of Mg wires was restricted, and SS wires were introduced instead.…”

Section: The Evolution Of Metallic Wires In Bone Fixation Devicesmentioning

confidence: 99%

Biodegradable Metallic Wires in Dental and Orthopedic Applications: A Review

Asgari

Hang

Chang

et al. 2018

Metals

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Abstract:Owing to significant advantages of bioactivity and biodegradability, biodegradable metallic materials such as magnesium, iron, and zinc and their alloys have been widely studied over recent years. Metallic wires with superior tensile strength and proper ductility can be fabricated by a traditional metalworking process (drawing). Drawn biodegradable metallic wires are popular biodegradable materials, which are promising in different clinical applications such as orthopedic fixation, surgical staples, cardiovascular stents, and aneurysm occlusion. This paper presents recent advances associated with the application of biodegradable metallic wires used in dental and orthopedic fields. Furthermore, the effects of some parameters such as the surface modification, alloying elements, and fabrication process affecting the degradation rate as well as biocompatibility, bioactivity, and mechanical stability are reviewed in the most recent works pertaining to these materials. Finally, possible pathways for future studies regarding the production of more efficient biodegradable metallic wires in the regeneration of bone defects are also proposed.

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Section: The Evolution Of Metallic Wires In Bone Fixation Devicesmentioning

confidence: 99%

Biodegradable Metallic Wires in Dental and Orthopedic Applications: A Review

Asgari

Hang

Chang

et al. 2018

Metals

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“…Stainless steel and titanium are current metals used as bioinert and permeant Class-III implants for orthopaedic applications. Recently, bioactive or biodegradable metals have attracted great attention in research and development (R&D) of biomaterials for clinical applications [1][2][3][4]. Our recent clinical work showed that the bone grafting fixation using biodegradable pure Mg screw was beneficial for successful fixation of bony flap used for treatment of osteonecrosis of the femoral head (ONFH) in patients with steroid-associated osteonecrosis https://doi.org/10.1016/j.biomaterials.2020.119828 Received 4 October 2019; Received in revised form 7 January 2020; Accepted 25 January 2020 (SAON) where bony flap displacement was avoided and local bone density was increased accompanied by Mg-screw degradation, partially explained by the biologic effects of degraded Mg ions, yet like many available related clinical studies the scientific or mechanistic evidence was lacking [5].…”

Section: Introductionmentioning

confidence: 99%

Magnesium and vitamin C supplementation attenuates steroid-associated osteonecrosis in a rat model

Wang

et al. 2020

Biomaterials

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A B S T R A C TMagnesium (Mg)-based biometal attracts clinical applications due to its biodegradability and beneficial biological effects on tissue regeneration, especially in orthopaedics, yet the underlying anabolic mechanisms in relevant clinical disorders are lacking. The present study investigated the effect of magnesium (Mg) and vitamin C (VC) supplementation for preventing steroid-associated osteonecrosis (SAON) in a rat experimental model. In SAON rats, 50 mg/kg Mg, or 100 mg/kg VC, or combination, or water control was orally supplemented daily for 2 or 6 weeks respectively. Osteonecrosis was evaluated by histology. Serum Mg, VC, and bone turnover markers were measured. Microfil-perfused samples prepared for angiography and trabecular architecture were evaluated by micro-CT. Primary bone marrow cells were isolated from each group to evaluate their potentials in osteoblastogenesis and osteoclastogenesis. The mechanisms were tested in vitro. Histological evaluation showed SAON lesions in steroid treated groups. Mg and VC supplementation synergistically reduced the apoptosis of osteocytes and osteoclast number, and increased osteoblast surface. VC supplementation significantly increased the bone formation marker PINP, and the combination significantly decreased the bone resorption marker CTX. TNFα expression and oxidative injury were decreased in bone marrow in Mg/VC/combination group. Mg significantly increased the blood perfusion in proximal tibia and decreased the leakage particles in distal tibia 2 weeks after SAON induction. VC significantly elevated the osteoblast differentiation potential of marrow cells and improved the trabecular architecture. The combination supplementation significantly inhibited osteoclast differentiation potential of marrow cells. In vitro study showed promoting osteoblast differentiation effect of VC, and antiinflammation and promoting angiogenesis effect of Mg with underlying mechanisms. Mg and VC supplementation could synergistically alleviate SAON in rats, indicating great translational potentials of metallic minerals for preventing SAON.

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“…Ideally, the corrosion rate of the implant would match the rate at which the body tissue heals, as depicted in Fig. 1 [26].…”

Section: Medical Magnesium and Biocorrosionmentioning

confidence: 99%

Building towards a standardised approach to biocorrosion studies: a review of factors influencing Mg corrosion in vitro pertinent to in vivo corrosion

2017

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The factors that influence magnesium (Mg) corrosion in vitro are systematically evaluated from a review of the relevant literature. We analysed the influence of the following factors on Mg biocorrosion in vitro: (i) inorganic ions, including both anions and cations, (ii) organic components such as proteins, amino acids and vitamins, and (iii) experimental parameters such as temperature, pH, buffer system and flow rate. Considerations and recommendations towards a standardised approach to in vitro biocorrosion testing are given. Several potential simulated body fluids are recommended. Implementing a standardised approach to experimental parameters has the potential to significantly reduce variability between in vitro biocorrosion tests, and to help build towards a methodology that accurately and consistently mimics in vivo corrosion. However, there are also knowledge gaps with regard to how best to characterise the in vivo environment and corrosion mechanism. The assumption that blood plasma is the correct bodily fluid upon which to base in vitro methodologies is examined, and factors that influence the corrosion mechanism in vivo, such as specimen encapsulation, bear consideration for further studies.

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Current status on clinical applications of magnesium-based orthopaedic implants: A review from clinical translational perspective

Cited by 740 publications

References 111 publications

Biodegradable Metallic Wires in Dental and Orthopedic Applications: A Review

Biodegradable Metallic Wires in Dental and Orthopedic Applications: A Review

Magnesium and vitamin C supplementation attenuates steroid-associated osteonecrosis in a rat model

Building towards a standardised approach to biocorrosion studies: a review of factors influencing Mg corrosion in vitro pertinent to in vivo corrosion

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