Current status of verification practices in clinical biochemistry in Spain

Abstract

A total of 36% of Spanish laboratories do not use autoverification, despite the general implementation of laboratory information systems, most of them, with autoverification ability. Criteria and rules for seven routine biochemical tests were obtained.

Establishing and validating of an laboratory information system‐based auto‐verification system for biochemical test results in cancer patients

“…Verification of clinical laboratory reports involves different technicians in the pre‐analytical, analytical, and post‐analytical phases, particularly in specialized cancer hospitals which run thousands of biochemical tests every day. AV of biochemical tests is a significant part of decision‐making and has benefitted from the development and application of artificial intelligence to the medical field in the last 20 years . Although CLSI AUTO‐10A guideline has provided a general framework for AV, but it also advised each laboratory should design, implement, validate, and customize rules based on the needs of its own patient population.…”

“…AV of biochemical tests is a significant part of decision-making and has benefitted from the development and application of artificial intelligence to the medical field in the last 20 years. 4,11 Although CLSI AUTO-10A guideline has provided a general framework for AV, but it also advised each laboratory should design, implement, validate, and customize rules based on the needs of its own patient population. We previously found these rules were not applicable to cancer patients.…”

“…Therefore, biochemical tests for liver and kidney function are routinely performed for cancer patients, accounting for more than 50% of the total laboratory workload. The verification of these tests is a major post‐analytical process, and the accuracy and timely release of the results are crucial for medical decision‐making. In recent years, various auto‐verification (AV) systems have been incorporated into standard diagnosis.…”

Development and Implementation of Autoverification Rules for ELISA Results of HBV Serological Markers

“…8 Thus, laboratory technicians can focus on a small part of the potentially problematic samples after making use of autoverification rules. 9 Currently, laboratories worldwide are exploring and implementing autoverification 9 in many fields such as clinical chemistry analysis, 4,6,10,11 urine analysis, 12,13 clinical hematology tests, 14,15 and coagulation. 11,16 Although there is a nearly 20-year history of autoverification systems and the existence of these guidelines, there is still a lack of standardization mainly in the algorithms, the criteria used, and the verification limits applied.…”

“…11,16 Although there is a nearly 20-year history of autoverification systems and the existence of these guidelines, there is still a lack of standardization mainly in the algorithms, the criteria used, and the verification limits applied. 10 Most researchers focus on praising the advantages of autoverification, but it has remained unclear how to build autoverification rules and parameters. 8,11 The chemiluminescent microparticle immunoassay (CMIA) [17][18][19] represents the most advanced technology of detecting hepatitis B markers.…”