Current status of vaccines in psychiatry—A narrative review

Kuppili, Pooja Patnaik; Manohar, Harshini; Menon, Vikas

doi:10.1016/j.ajp.2018.02.004

Cited by 6 publications

(3 citation statements)

References 65 publications

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“…In the following years many systematic reviews were done, which proved that there is no causality between the MMR vaccine and autism [27]. The systematic review by Demicheli et al, which included 14,700,000 children, found a significantly higher risk of febrile seizure after MMR vaccine exposure, but could not find any association between the vaccine and autism [28].…”

Section: Assertionmentioning

confidence: 99%

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Vaccine hesitancy

Weitz

Bellach

Faltum

et al. 2020

Wien Klin Wochenschr

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SummaryIn summer 2019 an extracurricular activity was started at the Medical University of Vienna (MUW) with the title: “Esoterism in Medicine”, where different chapters were evaluated by students. Here we present the subheading “Vaccine Hesitancy”. Three students formulated arguments from sceptic, hesitant or anti-vaccine groups and discussed the scientific literature to rebut it. Frequent objections were partly taken from the homepage of the German Robert-Koch-Institute, the home of the “Ständige Impfkommission”. Other objections were taken from blogs and social media. The students’ rebuttal was based on current scientific literature (preferentially pubmed), but also from other scientific sources like authorities.

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Section: Assertionmentioning

confidence: 99%

“…Measles in the first year of life has the highest mortality and the highest risk (1:600 infected) of developing deadly subacute sclerosing panencephalitis (SSPE). Before 2002 it was found that 50% of SSPE cases were diagnosed in children <2 years old [27].…”

Section: Assertionmentioning

confidence: 99%

Vaccine hesitancy

Weitz

Bellach

Faltum

et al. 2020

Wien Klin Wochenschr

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“…After M. bovis infects the body, it secretes various antigens during the reproduction process to induce the body to produce corresponding antibodies, and antibodies of the IgG class predominate mainly in the late stages of infection [ 8 ]. Antibodies which induce during infections, can block the proliferation of bacteria or viruses and trigger complement reactions, and the antibody levels are positively correlated with the course of the disease [ 9 ]. Therefore, detecting the level of IgG antibodies in serum is of great significance for diagnosis.…”

Section: Introductionmentioning

confidence: 99%

A combined application of molecular docking technology and indirect ELISA for the serodiagnosis of bovine tuberculosis

et al. 2022

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Background There is an urgent need to find reliable and rapid bovine tuberculosis (bTB) diagnostics in response to the rising prevalence of bTB worldwide. Toll-like receptor 2 (TLR2) recognizes components of bTB and initiates antigen-presenting cells to mediate humoral immunity. Evaluating the affinity of antigens with TLR2 can form the basis of a new method for the diagnosis of bTB based on humoral immunity. Objectives To develop a reliable and rapid strategy to improve diagnostic tools for bTB. Methods In this study, we expressed and purified the sixteen bTB-specific recombinant proteins in Escherichia coli . The two antigenic proteins, MPT70 and MPT83, which were most valuable for serological diagnosis of bTB were screened. Molecular docking technology was used to analyze the affinity of MPT70, MPT83, dominant epitope peptide of MPT70 (M1), and dominant epitope peptide MPT83 (M2) with TLR2, combined with the detection results of enzyme-linked immunosorbent assay to evaluate the molecular docking effect. Results The results showed that interaction surface Cα-atom root mean square deviation of proteins (M1, M2, MPT70, MPT83)-TLR2 protein are less than 2.5 A, showing a high affinity. It is verified by clinical serum samples that MPT70, MPT83, MPT70-MPT83 showed good diagnostic potential for the detection of anti-bTB IgG and M1, M2 can replace the whole protein as the detection antigen. Conclusions Molecular docking to evaluate the affinity of bTB protein and TLR2 combined with ELISA provides new insights for the diagnosis of bTB.

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