Current status of top 10 nutraceuticals used for Knee Osteoarthritis in India

Abstract

Knee Osteoarthritis (OA) is a progressive degenerative joint disease affecting the quality of life of the elderly population. There is considerable evidence that nutraceuticals from natural herbs may play a significant role in inflammation and joint destruction in OA. We review the current status of some of the commonly used nutraceuticals in Indian market e Boswellia, Aflapin, Chondroitin sulphate, Glucosamine sulphate, Collagen peptide, Curcumin, Fish Oil, Ginger, Green tea, and Rosehip extract. We have summarized their mechanism of action, biological effects, toxicities and efficacy in the management of Knee OA. These supplements have been found to be effective in knee OA in various studies. No serious side effects have been reported for any of these supplements. Overall, our study identifies and support the use of these nutraceuticals to provide symptomatic relief to patients with knee OA and justify their use as an adjunct therapy for the management. More good quality trials are needed to provide definitive answers to questions related to their efficacy and safety for OA prevention and treatment.

Nutritional, metabolic and genetic considerations to optimise regenerative medicine outcome for knee osteoarthritis

“…Vaishya et al, the impact of various nutraceuticals in the management of KOA. 15 Studies show the anti-inflammatory effect of Boswellia in KOA patient through decreasing the production of inflammatory MMPs, and report a generalized decrease in inflammation levels, which supports regenerative medicine applications. Active individuals with increased risk of developing KOA due to wear and tear are advised to supplement with Glucosamine sulfate (GS) due to its properties in supporting bone health.…”

“…GS contributes to the synthesis of chondrocytes, studies show its epigenetic impact of inflammatory markers. 15 Although various nutraceuticals have demonstrated to effectively reduce inflammation, oxidative stress and catabolic activity, their effects on disease modification have not yet been clearly demonstrated or are still under investigation. Further high-quality research is needed to evaluate clinical effects of nutraceuticals when used prior and/or post regenerative medicine treatments, and whether the effects change when used concurrently with regenerative techniques, or if nutraceuticals are better serveing as complementary medicine for the management of KOA.…”

Nutraceutical Alternatives to Pharmaceutical Analgesics in Osteoarthritis

“…As such, the following sections will discuss those nutraceuticals that are currently not in mainstream use but may have the potential to aid in treatment of OA (i.e. the well discussed Glucosamine and Chondroitin will not feature in this chapter) but are in regular use worldwide [280]. The identified nutraceuticals that have been compared to/with NSAID/analgesics for OA can be divided into three categories, defined by their origin, and are presented in Table 2; 1.…”

Assessment of safety and efficacy of Karallief® Easy ClimbTM, an herbal extract blend for supporting joint health: a double-blind, placebo-controlled, randomized clinical trial

“…12 Alternative approaches to improve symptoms and reduce pain have been explored as options for the treatment of osteoarthritis. 13,14 This study was conducted to test the efficacy and safety of two such proprietary herbal extract blends, KEC and HEG, in improving the symptoms of knee osteoarthritis as compared to a placebo control.…”