Current Status of the Diagnosis and Treatment of Thymoma

Graeber, Geqjfrey M.; Tamim, Wael

doi:10.1053/stcs.2000.17955

Cited by 33 publications

(27 citation statements)

References 46 publications

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“…Ogawa and his colleagues (29) have demonstrated that if no surgery taken, radiotherapy only resulted in 44% 5-year survival rate. Another study revealed that the 5-and 10-year survival rates were 53% and 44% if patients with stage III thymoma only received radiotherapy (30). It appears that among patients with advanced thymoma, complete resection with preoperative radiotherapy is much better than radiotherapy only.…”

Section: Discussionmentioning

confidence: 99%

Reconstruction of mediastinal vessels for invasive thymoma: a retrospective analysis of 25 cases

Sun

Shi

et al. 2017

J. Thorac. Dis.

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Background: Discuss an appropriate strategy for treatment of invasive thymoma invading adjacent great vessels.Methods: A retrospective study on 25 patients with invasive thymoma invading neighboring great vessels was performed. The corresponding data including clinical presentation, operation procedure, adjuvant radiochemotherapy and follow-up were reviewed. Postoperatively, three cases suffered from pulmonary infection, and three cases had haemothorax, chylothorax and atelectasis, respectively. Two patients died due to acute respiratory distress syndrome within 90 days after the surgery. Within the remaining patients, 11 cases (44%) experienced a relapse and finally 8 (32%) patients died. Compared to R1 resection group, R0 resection group had a better prognosis (Log-rank P=0.0196). The 3-and 5-year survival rates were 79.6% and 59.1%, with median survival time of 84 months.Conclusions: Reconstruction of mediastinal vessels for invasive thymoma is a feasible technology method.Radical resection of the tumor with involved neighboring structures is the key to prolong overall survival for patients suffered from invasive thymoma.

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Section: Discussionmentioning

confidence: 99%

Reconstruction of mediastinal vessels for invasive thymoma: a retrospective analysis of 25 cases

Sun

Shi

et al. 2017

J. Thorac. Dis.

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“…However, about one-third of patients demonstrate extensive growth, and lymph node or hematogenous metastasis, which may occur in both encapsulated and invasive types (1). The sites of hematogenousmetastasis include lung, liver, bone, and others (2). In this case, both primary and metastatic lesions of thymoma were surgically extirpated and exhibited positive reactivity to immunohistochemical staining for KL-6.…”

Section: Introductionmentioning

confidence: 87%

KL-6-producing Invasive Thymoma.

et al. 2002

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Wereport a patient with KL-6-producing invasive thymoma.A 58-year-old man was admitted complaining of dyspnea and fatigability. Computedtomography of the chest revealed interstitial pneumoniaand an anterior mediastinal tumor. The tumor was surgically extirpated and diagnosed as invasive thymoma. Serum KL-6 levels later increased further and another tumor was found in the liver. That liver tumor was resected and histologically diagnosed as a metastasis of thymoma.Following resection, the serum KL-6 level decreased. Tumor cells of both primary and metastatic lesions exhibited positive reactivity to immunohistochemical staining for KL-6. A review of this case is presented. (Internal Medicine 41: 979-982, 2002)

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Section: Discussionmentioning

confidence: 99%

“…It is still a matter of debate whether radiation therapy should be used for completely resected invasive thymomas [8]. Recent studies have indicated that whole mediastinum irradiation is effective in preventing mediastinal recurrence [8]. However, in patients with pleural invasion of the tumour determined by microscopic examination, mediastinal irradiation alone was insufficient to avoid pleural-based recurrence [9].…”

Section: Discussionmentioning

confidence: 99%

A 75-year-old female with dyspnoea and chest pain

Tresinie¹

2005

European Respiratory Journal

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Current Status of the Diagnosis and Treatment of Thymoma

Cited by 33 publications

References 46 publications

Reconstruction of mediastinal vessels for invasive thymoma: a retrospective analysis of 25 cases

Reconstruction of mediastinal vessels for invasive thymoma: a retrospective analysis of 25 cases

KL-6-producing Invasive Thymoma.

A 75-year-old female with dyspnoea and chest pain

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