Current status of tests of carbaryl for reproductive and teratogenic effect

Weil, Carrol S.; Woodside, M.D.; Carpenter, Charles P.; Smyth, Henry F.

doi:10.1016/0041-008x(72)90159-7

Cited by 33 publications

(11 citation statements)

References 17 publications

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“…The data from the individual pesticide treatment groups is in agreement with the work of other investigators (Khera et al, 1978;Weil et al, 1972). Khera et al (1978) showed that doses as high as 300 mg malathion/kg administered only on d 6-15 of gestation produced no significant effect on maternal weight gain, fetal weights, and the number of implants, live fetuses, or resorption sites per dam.…”

Section: Discussionsupporting

confidence: 86%

“…Khera et al (1978) showed that doses as high as 300 mg malathion/kg administered only on d 6-15 of gestation produced no significant effect on maternal weight gain, fetal weights, and the number of implants, live fetuses, or resorption sites per dam. Also, treatment during the entire gestational period with doses as high as 500 mg carbaryl/kg made no significant alteration in the number of implants, live fetuses or resorptions sites per dam (Weil et al, 1972).…”

Section: Discussionmentioning

confidence: 98%

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A teratology study of carbaryl and malathion mixtures in rat

Lechner¹,

Abdel‐Rahman²

1984

Journal of Toxicology and Environmental Health

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Recently, much controversy has developed in relation to the use of pesticides alone and in mixtures. Mixtures are used as a more efficient method of pest control. Carbaryl and malathion are one of many combinations used today. A limited amount of work has been done with these two pesticides in relation to their teratogenic potential. This study examined the teratological parameters of carbaryl and malathion in combination compared to the effect of the individual insecticides. Formulation grade carbaryl (0, 1, 10, and 100 mg/kg), formulation grade malathion (1 and 50 mg/kg), and a formulation grade mixture of carbaryl/malathion (1/1 and 50/50 mg/kg) were administered daily by gavage for 3 mo prior to and throughout gestation. Dams were sacrificed on d 20 of gestation, and the fetuses were examined for external, skeletal, and visceral malformations. Significant decreases in dam weight gain during pregnancy and a slight decrease in the number of implantations and number of live fetuses per dam were observed with the 100-mg/kg carbaryl group and were further reduced in both combination doses. The combination dose groups showed a significant reduction in placenta weight. No increases were seen in skeletal or visceral anomalies for the individual treatment groups; however, an increase in external hemorrhagic spots was observed with malathion at 50 mg/kg and the high-dosage mixture group.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 98%

A teratology study of carbaryl and malathion mixtures in rat

Lechner¹,

Abdel‐Rahman²

1984

Journal of Toxicology and Environmental Health

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“…Weil et al (1972Weil et al ( , 1973 giving Carbaryl per os in the diet (2.5 to 200 mg/ kg/ day) or by intubation (3 to 100 mg/ kg) observed no embryotoxic or teratogenic effects. In the Osborne-Mendel strain, rats receiving Carbaryl in the diet (5000 ppm) showed a slight decrease in litter size.…”

Section: Carbamate Insecticidesmentioning

confidence: 92%

“…at doses of 20, 100, and 500 mg/ kg/ day, Carbaryl was neither embryotoxic nor teratogenic (Weil et at., 1972 (1973) observed no embryotoxic or teratogenic activity after oral treatment in the diet (100, 200, and 300 mg/ kg/ day), or by intubation (30, 100, and 200 mg/ kg/ day) from the 10th to 24th day p.c. A three-generation study was performed with Mongolian gerbils receiving 2000, 4000, 6000, and 10,000 ppm Carbaryl in the diet (Collins et al, 1971 b).…”

Section: Carbamate Insecticidesmentioning

confidence: 97%

Mutagenicity, Carcinogenicity, and Teratogenicity of Insecticides

Moutschen-Dahmen

Degraeve

1984

Mutagenicity, Carcinogenicity, and Teratogenicity of Industrial Pollutants

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“…Recording done also to the number of live and dead mice generation F-1 at birth, number of pups living mice on post natal (PN) -1, PN-4 and PN-21. To calculate the perinatal mortality index is the number of pups born die divided by the number of pups born multiplied by 100%, while viability index on PN-4 is the number of pups living in the PN-4 divided by the number of pups living in the PN-0 multiplied by 100% (Weil et al, 1972). Determination of fertility of the F-1 offspring were undertaken by mating interlitter.Mating patterns consisted of four combinations are: I. K X K, II.…”

Section: Methodsmentioning

confidence: 99%

Effect of Zearalenone Administrated at Late Gestation Days on Fertility of The F-1 Offspring in Swiss webster (Mus musculus)

Irnidayanti

2012

Int. J. Morphol.

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SUMMARY:Zearalenone solution was given to dams mice subcutaneously at a dose of 30 mg/kg body weight at the age of pregnancy 13 to 18 days. Control mice were given only sesame oil. Furthermore, dams mice were allowed to deliver their litter and pups were weaned on 21 days of age. The live birth index and viability of the F-1 offspring were recorded. Determination of fertility of the F-1 offspring were undertaken by mating interlitters. On days 18 of gestation, the F-1 offspring were killed by cervical dislocation. The observation was performed on the number of live or dead fetus, embryo resorption, the number of implantation and the percentage of gestation loss. The result revealed that administration of zearalenone on days 13 to 18 of gestation caused a significant decreasein the number of implantation as the result of mating between control male with treated female and treated male with tretaed female of the F-1 offspring. It could be concluded that in the F-1 offspring, zearalenone interfered the process of ovarian develoment, stimulated the differentation of the uterus, decreased the fertility of the female and the effect of zearalenon was more persistent in the female than in the male

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Current status of tests of carbaryl for reproductive and teratogenic effect

Cited by 33 publications

References 17 publications

A teratology study of carbaryl and malathion mixtures in rat

A teratology study of carbaryl and malathion mixtures in rat

Mutagenicity, Carcinogenicity, and Teratogenicity of Insecticides

Effect of Zearalenone Administrated at Late Gestation Days on Fertility of The F-1 Offspring in Swiss webster (Mus musculus)

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