Current Status of Problem of Early Diagnosis of Ovarian Cancer and Its Solutions (Literature Review)

Макаров, О. В.; Moshkovskii, Sergei A.; Карпова, М. А.; Narimanova, M.R.

doi:10.17650/1994-4098-2015-1-76-82

Cited by 2 publications

(1 citation statement)

References 39 publications

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“…Основным принципом большинства современных исследований в области разработки биохимических диагностических методов является поиск панелей биомаркеров и комбинирование биомаркеров. В настоящее время стала возможной идентификация одновременно большого количества белков и генов методом профилирования биологического материала (транскриптомного и протеомного), а также сравнение профилей экспрессии генов в клетках здоровых и больных людей с помощью ДНК-микрочипов [43]. К недостаткам использования микрочипов на основе антител относят высокую стоимость расходных материалов и необходимость иметь антитела ко всем анализируемым белкам.…”

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The differential diagnosis of benign and malignant ovarian neoplasms (history)

et al. 2016

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The history of the differential diagnosis of ovarian neoplasms at the preoperative stage is presented in the review article. This is still a problem due to the high incidence of tumors and tumor-like formations of ovaries, the continuing upward trend in the index of ovarian cancer, along with a slight decrease in mortality and 5-year survival. Considerable success of surgical treatment and chemotherapy in the early stages of ovarian cancer suggests the earliest possible detection and accuracy of differential diagnosis of ovarian neoplasms. It highlights the role of the different research methods, including radiation imaging techniques, tumor markers and their potential advantages and disadvantages.

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The differential diagnosis of benign and malignant ovarian neoplasms (history)

et al. 2016

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Optimization of early diagnosis of ovarian cancer using an original software ScOv

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et al. 2019

Opuholi ženskoj reproduktivnoj sistemy

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The most common causes of treatment failure in ovarian cancer (ОС) include late diagnosis due to the absence of screening programs for its early detection and lack of vigilance by general practitioners and gynecologists. World experience suggests that screening of 100% of women has a minimal impact on mortality. Examination of women at high risk for OC is a sensible alternative to mass screening. This examination can be performed using universal computerized screening, which is a very promising and cost-effective method.To identify the symptoms significantly associated with early-stage OC, we questionnaired 100 patients with morphologically verified stage IA–IC OC, admitted to the Department of Gynecology, Tula Regional Oncology Dispensary between 2010 and 2017 (experimental group). The control group included 200 women without malignant diseases, who underwent preventive medical examination in outpatient units of Tula. We analyzed the significance of 22 clinical symptoms and developed original computer software ScOv, which was subsequently used for identifying patients at high risk of OC among women aged 40 years and older by evaluating their complaints. The sensitivity and specificity of ScOv were 73.7 % and 88.8 % respectively. A retrospective check of the developed program demonstrated its high efficiency and prognostic value.

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Current Status of Problem of Early Diagnosis of Ovarian Cancer and Its Solutions (Literature Review)

Cited by 2 publications

References 39 publications

The differential diagnosis of benign and malignant ovarian neoplasms (history)

The differential diagnosis of benign and malignant ovarian neoplasms (history)

Optimization of early diagnosis of ovarian cancer using an original software ScOv

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