Current status of Neisseria gonorrhoeae cervicitis in pregnant women in Japan

Suzuki, Shunji; Hoshi, Shinichi; Sekizawa, Akihiko; Sagara, Yoko; Tanaka, Masanobu; Kinoshita, Katsuyuki; Kitamura, Tadaichi

doi:10.1371/journal.pone.0211595

Cited by 7 publications

(3 citation statements)

References 17 publications

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“…This difference may be due to N. gonorrhoeae infection more often being symptomatic than C. trachomatis or M. genitalium infections, and therefore easier to diagnose during pregnancy. In other studies of pregnant women, the prevalence of N. gonorrhoeae has varied considerably, from 0% in France to 1.3% in Japan, 38,42 depending on variables such as age and geographical origin or ethnicity 43–45 …”

Section: Discussionmentioning

confidence: 99%

Prevalence of Chlamydia trachomatis, Mycoplasma genitalium, and Neisseria gonorrhoeae infections in a screening program for under‐30‐year‐old pregnant women with a high participation rate in northern Spain (2016–2020)

Piñeiro

Zubikarai

Manzanal

et al. 2022

Repro Female Child Health

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To assess a screening program for sexually transmitted infections (STIs) in under-30-year-old pregnant women, focusing on Chlamydia trachomatis, Neisseria gonorrhoeae and Mycoplasma genitalium infections, which though often asymptomatic, may significantly affect women's health and can be vertically transmitted. Design: Prospective, descriptive, observational study. Setting: Gipuzkoa (Basque Country, Spain). Population: Under-30-year-old pregnant women. Methods: Between 2016 and 2020, cervical samples were taken at first prenatal appointments from 3051 women. STIs were detected by multiplex nucleic acid amplification. Main Outcome Measures: Prevalence of infections by age and geographical origin groups, and screening coverage. Results: The coverage rate was 86% between 2017 and 2020. At least one STI was detected in 5.2% of the under-30-year-olds screened (95% confidence interval [CI]: 4.5%, 6.1%): C. trachomatis in 4%, M. genitalium in 1.3% and N. gonorrhoeae in 0.1%. C. trachomatis and M. genitalium prevalence rates were higher among younger women (7.2% and 2.8%, respectively in under-25-year-olds), while C. trachomatis prevalence in 25-to 30-year-olds was 2.5%. C. trachomatis was more common among Latin American women (9.7% [95% CI: 7.4%, 12.3%] vs. 2.5% [95% CI: 2.0%, 3.2%] in other women). Additionally, analysing samples from 708 pregnant over-30-year-old women with STI risk factors, 1.6% had at least one of the STIs studied. Notably, 20% of all cases had STI-related symptoms or complications during pregnancy. Conclusions: The high coverage achieved, and prevalence, clinical and epidemiological results support the view that the implementation of a screening program across Spain for C. trachomatis in under-30-year-old pregnant women would be both feasible and appropriate.

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Section: Discussionmentioning

confidence: 99%

Prevalence of Chlamydia trachomatis, Mycoplasma genitalium, and Neisseria gonorrhoeae infections in a screening program for under‐30‐year‐old pregnant women with a high participation rate in northern Spain (2016–2020)

Piñeiro

Zubikarai

Manzanal

et al. 2022

Repro Female Child Health

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“…This results in many pregnant women not being diagnosed with cervical infections. A previous study involving 1,876 pregnant women in Japan noted that 84% of pregnant women with gonococcal cervicitis may have been missed in hospitals that do not routinely perform the screening test for gonococcal cervicitis ( 115 ). These pregnant women who are not diagnosed with cervical infection are also not given the proper management that can help in preventing ascending infections during pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Breaking Down the Barrier: The Role of Cervical Infection and Inflammation in Preterm Birth

Tantengco

Menon

2022

Front. Glob. Womens Health

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Approximately 40% of cases of spontaneous preterm birth (sPTB) are associated with ascending intrauterine infections. The cervix serves as a physical and immunological gatekeeper, preventing the ascent of microorganisms from the vagina to the amniotic cavity. The cervix undergoes remodeling during pregnancy. It remains firm and closed from the start until the late third trimester of pregnancy and then dilates and effaces to accommodate the passage of the fetus during delivery. Remodeling proceeds appropriately and timely to maintain the pregnancy until term delivery. However, risk factors, such as acute and chronic infection and local inflammation in the cervix, may compromise cervical integrity and result in premature remodeling, predisposing to sPTB. Previous clinical studies have established bacterial (i.e., chlamydia, gonorrhea, mycoplasma, etc.) and viral infections (i.e., herpesviruses and human papillomaviruses) as risk factors of PTB. However, the exact mechanism leading to PTB is still unknown. This review focuses on: (1) the epidemiology of cervical infections in pregnant patients; (2) cellular mechanisms that may explain the association of cervical infections to premature cervical ripening and PTB; (3) endogenous defense mechanisms of the cervix that protect the uterine cavity from infection and inflammation; and (4) potential inflammatory biomarkers associated with cervical infection that can serve as prognostic markers for premature cervical ripening and PTB. This review will provide mechanistic insights on cervical functions to assist in managing cervical infections during pregnancy.

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“…It can also be manifested as frequent pain in the lower abdomen or lumbosacral region, as well as some bladder and bowel symptoms. The concomitant diseases of chronic cervicitis include cervical erosion, cervical valgus, cervical polyps, cervical retention cyst, and endocervicitis (8,9). It seriously affects the quality of life of patients and brings a huge burden to the body and mind of patients.…”

Section: Introductionmentioning

confidence: 99%

Loop Electrosurgical Excision Procedure under Propofol Intravenous Anesthesia Combined with Nano-Silver Gel in the Treatment of Cervicitis

Liu¹,

Zou²,

Sun³

et al. 2022

Cell Mol Biol (Noisy-le-grand)

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It was aimed at the therapeutic value of loop electrosurgical excision procedure (LEEP) under propofol intravenous anesthesia combined with nano-silver gel in chronic cervicitis. 100 patients with chronic cervicitis were selected and randomly divided into the control group with 50 cases (LEEP under intravenous anesthesia with fentanyl) and the experimental group with the other 50 cases (LEEP under propofol intravenous anesthesia combined with the nano-silver gel). It was suggested from the results that the mean arterial pressure (MAP) and heart rate (HR) (76.88±5.65mmHg, 75.45±5.06beats/min) of patients in the experimental group at T1 time were better than those of the control group (83.76±5.43mmHg, 68.31±5.28beats/min). Visual analogue scale (VAS) (1.85±0.73 points), onset time of anesthesia (0.56±0.21min), time to open eyes (2.45±1.38min) and time of consciousness recovery (5.22±1.42min) were all lower than those of the control group (2.83±0.79 points, 0.93±0.25min, 4.33±1.45min, and 7.15±1.34min, respectively). The incidence of adverse reactions, the effective rate of treatment, the time of wound healing, and the incidence of complications (6%, 94%, 23.83±2.05 days, and 6%, respectively) were all better than those of the control group (24%, 70%, 29.25±2.16 days, and 6%) (P<0.05). All in all, intravenous anesthesia with propofol was beneficial to perform LEEP better, and the combination of LEEP combined with nano-silver gel had an important value in the treatment of chronic cervicitis and was worthy of clinical promotion.

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Current status of Neisseria gonorrhoeae cervicitis in pregnant women in Japan

Cited by 7 publications

References 17 publications

Prevalence of Chlamydia trachomatis, Mycoplasma genitalium, and Neisseria gonorrhoeae infections in a screening program for under‐30‐year‐old pregnant women with a high participation rate in northern Spain (2016–2020)

Prevalence of Chlamydia trachomatis, Mycoplasma genitalium, and Neisseria gonorrhoeae infections in a screening program for under‐30‐year‐old pregnant women with a high participation rate in northern Spain (2016–2020)

Breaking Down the Barrier: The Role of Cervical Infection and Inflammation in Preterm Birth

Loop Electrosurgical Excision Procedure under Propofol Intravenous Anesthesia Combined with Nano-Silver Gel in the Treatment of Cervicitis

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