Current Status of Microneedle Array Technology for Therapeutic Delivery: From Bench to Clinic

Chakraborty, Chiranjib; Bhattacharya, Manojit; Lee, Sang-Soo

doi:10.1007/s12033-023-00961-2

Cited by 2 publications

(1 citation statement)

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“…The emergence of microneedle technology has provided potential insights for overcoming the stratum corneum barrier, resulting in the enhancement of the transdermal absorption rate. The microneedle is a chip-type transdermal drug delivery system fabricated by integrating hundreds of needle tips with a length of 25~2000 μm (mostly 100~1500 μm) on a matrix of ~1 cm 2 area [ 23 ]. It can create a large number of tiny pores within the skin as delivery channels to promote the penetration of drugs through physical penetration with the needles [ 24 ].…”

Section: Overcoming the Challenge With Dissolving Microneedlesmentioning

confidence: 99%

The Necessity to Investigate In Vivo Fate of Nanoparticle-Loaded Dissolving Microneedles

Chang,

Wu,

et al. 2024

Pharmaceutics

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Transdermal drug delivery systems are rapidly gaining prominence and have found widespread application in the treatment of numerous diseases. However, they encounter the challenge of a low transdermal absorption rate. Microneedles can overcome the stratum corneum barrier to enhance the transdermal absorption rate. Among various types of microneedles, nanoparticle-loaded dissolving microneedles (DMNs) present a unique combination of advantages, leveraging the strengths of DMNs (high payload, good mechanical properties, and easy fabrication) and nanocarriers (satisfactory solubilization capacity and a controlled release profile). Consequently, they hold considerable clinical application potential in the precision medicine era. Despite this promise, no nanoparticle-loaded DMN products have been approved thus far. The lack of understanding regarding their in vivo fate represents a critical bottleneck impeding the clinical translation of relevant products. This review aims to elucidate the current research status of the in vivo fate of nanoparticle-loaded DMNs and elaborate the necessity to investigate the in vivo fate of nanoparticle-loaded DMNs from diverse aspects. Furthermore, it offers insights into potential entry points for research into the in vivo fate of nanoparticle-loaded DMNs, aiming to foster further advancements in this field.

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Section: Overcoming the Challenge With Dissolving Microneedlesmentioning

confidence: 99%