Current Status of Management on Pharmacopuncture in Korea through Introduction of an Accreditation System

Sung, Soo-Hyun; Shin, Byung‐Cheul; Park, Min-Jung; Kim, Kyeong Han; Kim, Jiwon; Ryu, Ji-Yeon; Park, Jang-Kyung

doi:10.3831/kpi.2019.22.009

Cited by 16 publications

(14 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While medicinal products are usually administered by the MFDS, pharmacopuncture is implemented in Korea according to prescriptions issued to EHDs by TKM and TCM institutions [ 15 , 16 ]. An EHD is a type of pharmacy that offers various types and formulations of herbal medicines to TKM institutions according to TKM doctors’ prescriptions based on each patient’s condition and was legalized by the Ministry of Health and Welfare (MoHW) in Korea in 2008.…”

Section: Discussionmentioning

confidence: 99%

“…An EHD is a type of pharmacy that offers various types and formulations of herbal medicines to TKM institutions according to TKM doctors’ prescriptions based on each patient’s condition and was legalized by the Ministry of Health and Welfare (MoHW) in Korea in 2008. In September 2018, the MoHW announced that the Accreditation System of EHDs would be applied in TKM to evaluate and certify herbal and pharmacopuncture preparations [ 15 - 17 ].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Single-Dose Intramuscular Toxicity Study of SU-Eohyeol Pharmacopuncture in Rats

Hwang

Jung

2022

J Pharmacopuncture

View full text Add to dashboard Cite

Objectives This toxicological study was performed to assess for potential toxicity and to determine the approximate lethal dose of SU-Eohyeol pharmacopuncture (SUEP) following a single intramuscular injection of SUEP into male and female Sprague-Dawley (SD) rats. Methods The groups in our experiment consisted of an experimental group treated with SUEP at a dose of 1.0 mL/animal and a control group injected with a normal saline solution, and five male and female rats were placed in each group. Each animal was administered a single intramuscular injection. We monitored all rats for clinical signs and body weight changes for 14 days after administration. At the end of the observation period, the rats were euthanized and autopsied, and localized tolerance examinations were conducted at the site of administration of the test substance. Results There were no deaths in either sex in the SUEP-treated group. There was no significant difference between the SUEP-treated group and the control group in the clinical signs and weight changes among the rats. In addition, no significant SUEP-related changes were observed on autopsy findings or local tolerance examinations at the injection site by histopathological examination. Conclusion Our results suggest that the approximate lethal dose of a single intramuscular administration of SUEP in female and male rats under the conditions of this study is greater than 1.0 mL/animal. To determine the safety of the use of SUEP in Korean medical clinical practice, additional toxicity studies will be needed.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Single-Dose Intramuscular Toxicity Study of SU-Eohyeol Pharmacopuncture in Rats

Hwang

Jung

2022

J Pharmacopuncture

View full text Add to dashboard Cite

show abstract

“…In this study, satisfaction and intent to seek retreatment did not significantly differ between the BV-PA and non-BV-PA groups. This could be acceptable to BV-PA for patients, considering that compared to non-BV-PA, BV-PA is associated with more complicated procedures such as skin tests [6], severe pain [16], high costs [5], and the possibility of adverse events [23].…”

Section: Discussionmentioning

confidence: 99%

“…In the case of treatment, the PA was 24.1%, similar to that of the herbal medicine (26.8%) [4]. Eighty-eight percent of Korean medicine doctors (KMDs) administer PA, 35% of whom use BV, which is diluted to a ratio of less than 1:10,000 to minimize the side effects when as a PA solution [5,6]. BV is a complex compound consisting of several substances, some of which have anti-inflammatory [7], antinociceptive [8], radioprotective [9], antimutagenic [10], and anticancer [11,12] activities.…”

Section: Introductionmentioning

confidence: 99%

Characteristics of Adverse Events in Bee Venom Therapy Reported in South Korea: A Survey Study

Kim

Jeong

Lee

et al. 2021

Toxins

View full text Add to dashboard Cite

This study was aimed at investigating Korean patients’ experience with bee venom therapy (BVT) and providing evidence to enhance BVT safety. Thus, an anonymous online survey was conducted between August 22 and 28, 2018. Five hundred respondents who underwent pharmacopuncture (PA) within one year were surveyed (sample error: 95 ± 4.38%). Of these, 32 respondents were excluded and 468 were evaluated. Of the 468, 61 reported experiencing adverse events after PA. The adverse event rate was higher in the BV-PA(Bee venom-Pharmacopuncture) group than in the non-A group; however, intergroup differences were insignificant. There were no significant differences in mild symptom intensity between the BV-PA and non-BV-PA groups (p = 0.572). However, there was a significant intergroup difference in severe symptom intensity (p < 0.001). Additionally, the BV-PA and non-BV-PA groups did not significantly differ in their level of satisfaction either overall or in terms of effectiveness and safety (p = 0.414, p = 0.339, and p = 0.675, respectively). Furthermore, the BV-PA and non-BV-PA groups did not differ regarding intent to re-treat (p = 0.722). Severe adverse events such as anaphylactic shock were not reported; however, BVT practitioners should be cautious when applying it.

show abstract

“…Pharmacopuncture therapy using acupuncture agents prepared in single or mixed forms of herbal medicines is a commonly used treatment method in Korean medicine (KM). Pharmacopuncture combines the use of meridians and herbal factors and improve the delivery of herbal medicines to the target site [ 5 - 8 ]. It is important to note that the herbs used in pharmacopuncture are natural substances, and the manufacturing process may vary depending on the level of active ingredients present in the formulation [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Genotoxicity of SU-Eohyeol Pharmacopuncture Using an In Vitro Chromosome Aberration Test in Chinese Hamster Lung Cell

Ku¹,

Hwang

2022

J Pharmacopuncture

View full text Add to dashboard Cite

Objectives This study was conducted to evaluate the safety of SU-Eohyeol pharmacopuncture (SUEP) by assessing its potential to cause chromosomal abnormalities in Chinese hamster lung cells (CHL/IC). Methods A dose-curve was conducted to determine the highest dose of SUEP. Doses of 10, 5, 2.5, 1.25, 0.625, and 0.313% were used, and no cytotoxicity or SUEP precipitation was observed. SUEP doses of 10, 5, and 2.5%, with positive and negative controls, were used in a chromosome aberration test. Results In this study, the frequency of abnormal chromosomal cells in the SUEP group did not show a statistically significant difference from that of the negative control group in short-term treatments with and without metabolic activation and the continuous treatment without metabolic activation. Compared with the negative control group, the positive control group had a significantly higher frequency of cells with structural chromosomal abnormalities. This test’s results satisfied all conditions for determining the results. Conclusion SUEP did not induce chromosomal aberrations under the conditions of this study. Other toxicity evaluations, safety studies in humans, and various clinical trials are required to evaluate the safety and efficacy of SUEP.

show abstract

Current Status of Management on Pharmacopuncture in Korea through Introduction of an Accreditation System

Cited by 16 publications

References 20 publications

Single-Dose Intramuscular Toxicity Study of SU-Eohyeol Pharmacopuncture in Rats

Single-Dose Intramuscular Toxicity Study of SU-Eohyeol Pharmacopuncture in Rats

Characteristics of Adverse Events in Bee Venom Therapy Reported in South Korea: A Survey Study

Evaluation of Genotoxicity of SU-Eohyeol Pharmacopuncture Using an In Vitro Chromosome Aberration Test in Chinese Hamster Lung Cell

Contact Info

Product

Resources

About