Current Status of Long Non-Coding RNAs in Human Breast Cancer

Cerk, Stefanie; Schwarzenbacher, Daniela; Adiprasito, Jan Basri; Stotz, Michael; Hutterer, Georg C.; Gerger, Armin; Ling, Hui; Calin, George A.; Pichler, Martin

doi:10.3390/ijms17091485

Cited by 64 publications

(63 citation statements)

References 161 publications

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“…Accumulating evidence indicates that lncRNAs play critical roles in a spectrum of biological processes via transcriptional, post-transcriptional and epigenetic mechanisms [5]. Dysregulation of lncRNAs has been observed in various cancers, including breast cancer, colorectal cancer, lung cancer, prostate cancer as well as esophageal cancer [6–10]. It has been reported that dysregulated lncRNAs are associated with cancer pathogenesis and function as oncogenic or tumor suppressive regulators in cancer development [11].…”

Section: Introductionmentioning

confidence: 99%

Identification of a RNA-Seq Based 8-Long Non-Coding RNA Signature Predicting Survival in Esophageal Cancer

Fan

Liu

2016

Med Sci Monit

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BackgroundAccumulating evidence suggests the involvement of long non-coding RNAs (lncRNAs) as oncogenic or tumor suppressive regulators in the development of various cancers. In the present study, we aimed to identify a lncRNA signature based on RNA sequencing (RNA-seq) data to predict survival in esophageal cancer.Material/MethodsThe RNA-seq lncRNA expression data and clinical information were downloaded from The Cancer Genome Atlas (TCGA) database. Differentially expressed lncRNAs were screened out between esophageal cancer and normal tissues. Univariate and multivariate Cox regression analysis were performed to establish a lncRNA-related prognostic model. Receiver operating characteristic (ROC) analysis was conducted to test the sensitivity and specificity of the model. GO (gene ontology) functional and KEGG pathway enrichment analyses were performed for mRNAs co-expressed with the lncRNAs to explore the potential functions of the prognostic lncRNAs.ResultsA total of 265 differentially expressed lncRNAs were identified between esophageal cancer and normal tissues. After univariate and multivariate Cox regression analysis, eight lncRNAs (GS1-600G8.5, LINC00365, CTD-2357A8.3, RP11-705O24.1, LINC01554, RP1-90J4.1, RP11-327J17.1, and LINC00176) were finally screened out to establish a predictive model by which patients could be classified into high-risk and low-risk groups with significantly different overall survival. Further analysis indicated independent prognostic capability of the 8-lncRNA signature from other clinicopathological factors. ROC curve analysis demonstrated good performance of the 8-lncRNA signature. Functional enrichment analysis showed that the prognostic lncRNAs were mainly associated with esophageal cancer related biological processes such as regulation of glucose metabolic process and amino acid and lipids metabolism.ConclusionsOur study developed a novel candidate model providing additional and more powerful prognostic information beyond conventional clinicopathological factors for survival prediction of esophageal cancer patients. Moreover, it also brings us new insights into the molecular mechanisms underlying esophageal cancer.

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Section: Introductionmentioning

confidence: 99%

Identification of a RNA-Seq Based 8-Long Non-Coding RNA Signature Predicting Survival in Esophageal Cancer

Fan

Liu

2016

Med Sci Monit

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“…A number of lncRNAs have been shown to be involved in a wide range of biological functions including RNA processing, 10,11 gene transcription regulation, 1 miRNAs' host genes, 2 modulation of apoptosis and invasion, 4 marker of cell fate, 5 and chromatin modification. 6 Altered expression of lncRNAs has been documented in human gastric cancer, prompting increased interest in their potential use as biomarkers for diagnosis and prognosis, in addition to their potential roles as therapeutic targets.…”

Section: Introductionmentioning

confidence: 99%

Long non-coding RNA MSTO2P promotes the proliferation and colony formation in gastric cancer by indirectly regulating miR-335 expression

et al. 2017

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Long non-coding RNAs are emerging as new players in gene regulation, but whether long non-coding RNAs influence the expression of microRNA is unclear. The expression levels of misato family member 2, pseudogene were significantly associated with lymphatic metastasis and distal metastasis in 80 paired gastric cancer tissues using real-time quantitative reverse transcription polymerase chain reaction experiments. The effects of long non-coding RNA misato family member 2, pseudogene were assessed by overexpressing or downexpressing long non-coding RNA misato family member 2, pseudogene in gastric cancer cells. Long non-coding RNA misato family member 2, pseudogene promoted gastric cancer cell growth, colony formation, migration, and invasion in gastric cancer cells. Long non-coding RNA misato family member 2, pseudogene influenced biologic functions in gastric cancer cells via indirectly regulating the activation of miR-335. Our results reveal long non-coding RNA misato family member 2, pseudogene as an oncogenic long non-coding RNA that promotes cell growth and invasion. Therefore, long non-coding RNAs might function as key regulatory hubs in gastric cancer progression.

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“…Enormous studies have proven that lncRNAs were associated with tumorgenesis, progression, metastasis, and drug resistance, functioning as oncogenes, tumor suppressor genes, or both, involving in shaping multiple biological characteristics of cancer at transcriptional, posttranscriptional, and epigenetic levels . In addition, the abnormal expression levels of different lncRNAs with oncogenic and tumor suppressor functions have been frequently found in the development of BC . Particularly, adverse rules of miRNAs‐sponging lncRNAs, involved in ceRNA networks (ceRNETs), have been shown in BC .…”

Section: Introductionmentioning

confidence: 99%

Characterization of lncRNA LINC00520 and functional polymorphisms associated with breast cancer susceptibility in Chinese Han population

Guo

Peng

et al. 2020

Cancer Medicine

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Background The aim was to evaluate the association between the LINC00520 genetic polymorphisms and breast cancer (BC) susceptibility. Methods Nine single‐nucleotide polymorphisms (SNPs) on LINC00520 genotyping were performed in 504 BC patients and 505 cancer‐free controls in Chinese Han population to study the relationship between LINC00520 polymorphism and BC susceptibility. qRT‐PCR and luciferase tests were used to explore how rs12880540 affected the expression of LINC00520. Results The genotype GG (OR:3.58, 95%CI:1.32‐9.69) in rs8012083 increased the risk of triple‐negative BC. The genotype GG (OR:0.31, 95%CI:0.14‐0.69) in rs8012083, the genotype AA (OR:2.74, 95%CI:1.01‐7.42) in rs2152275, and genotype TG (OR:1.62, 95%CI:1.04‐2.52) in rs12880540 were associated with HER‐2 status. The dominant (OR:0.65, 95%CI:0.45‐0.95) and overdominant genetic model (OR:0.67, 95%CI:0.46‐0.98) consistently showed that rs11622641 T was significantly associated with lower risk of BC. Similarly, the recessive genetic model (OR:1.57, 95%CI:1.07‐2.30) of rs12880540 and the dominant (OR:1.62, 95%CI:1.24‐2.11) and overdominant (OR:1.56, 95%CI:1.19‐2.03) genetic model of rs2152278 may increase the risk of BC. The relative expression of LINC00520 increased linearly with the increase in the number of rs12880540 mutations. rs12880540 alleles were due to the interaction between LINC00520 and miR‐3122 at T, but the mutation of rs12880540 G > T had no effect on the binding ability of LINC00520 and miR‐3122. Conclusion A genetic variant of rs8012083 in LINC00520 may be used as a biomarker for triple‐negative BC after further evaluation of diagnostic tests. The genetic variant of LINC00520 was related to the susceptibility of BC, and rs12880540 might affect the corresponding mRNA expression of lncRNA LINC00520.

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Current Status of Long Non-Coding RNAs in Human Breast Cancer

Cited by 64 publications

References 161 publications

Identification of a RNA-Seq Based 8-Long Non-Coding RNA Signature Predicting Survival in Esophageal Cancer

Identification of a RNA-Seq Based 8-Long Non-Coding RNA Signature Predicting Survival in Esophageal Cancer

Long non-coding RNA MSTO2P promotes the proliferation and colony formation in gastric cancer by indirectly regulating miR-335 expression

Characterization of lncRNA LINC00520 and functional polymorphisms associated with breast cancer susceptibility in Chinese Han population

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