Current status of intratumoral therapy for glioblastoma

Mehta, Ankit I.; Linninger, Andreas A.; Lesniak, Maciej S.; Engelhard, Herbert H.

doi:10.1007/s11060-015-1875-1

Cited by 42 publications

(27 citation statements)

References 46 publications

(54 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…At present, CNTs do not efficiently cross the BBB 22 . However, advances in the use of catheter driven infusion strategies such as convection enhanced delivery (CED) 23 may allow for tumor specific delivery of CNTs. CED bypasses the BBB and relies on pressure-driven infusion through an intracranial catheter to distribute macromolecules along a pressure gradient rather than relying only on diffusion.…”

Section: Introductionmentioning

confidence: 99%

Photothermal Therapy of Glioblastoma Multiforme Using Multiwalled Carbon Nanotubes Optimized for Diffusion in Extracellular Space

Eldridge

Bernish

Fahrenholtz

et al. 2016

ACS Biomater. Sci. Eng.

View full text Add to dashboard Cite

Glioblastoma multiforme (GBM) is the most common and most lethal primary brain tumor with a 5 year overall survival rate of approximately 5%. Currently, no therapy is curative and all have significant side effects. Focal thermal ablative therapies are being investigated as a new therapeutic approach. Such therapies can be enhanced using nanotechnology. Carbon nanotube mediated thermal therapy (CNMTT) uses lasers that emit near infrared radiation to excite carbon nanotubes (CNTs) localized to the tumor to generate heat needed for thermal ablation. Clinical translation of CNMTT for GBM will require development of effective strategies to deliver CNTs to tumors, clear structure-activity and structure-toxicity evaluation, and an understanding of the effects of inherent and acquired thermotolerance on the efficacy of treatment. In our studies, we show that a dense coating of phospholipid-poly(ethylene glycol) on multiwalled CNTs (MWCNTS) allows for better diffusion through brain phantoms, while maintaining the ability to achieve ablative temperatures after laser exposure. Phospholipid-poly(ethylene glycol) coated MWCNTs do not induce a heat shock response (HSR) in GBM cell lines. Activation of the HSR in GBM cells via exposure to sub-ablative temperatures or short term treatment with an inhibitor of heat shock protein 90 (17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (17-DMAG)), induces a protective heat shock response that results in thermotolerance and protects against CNMTT. Finally, we evaluate the potential for CNMTT to treat GBM multicellular spheroids. These data provide pre-clinical insight into key parameters needed for translation of CNMTT including nanoparticle delivery, cytotoxicity, and efficacy for treatment of thermotolerant GBM.

show abstract

Section: Introductionmentioning

confidence: 99%

Photothermal Therapy of Glioblastoma Multiforme Using Multiwalled Carbon Nanotubes Optimized for Diffusion in Extracellular Space

Eldridge

Bernish

Fahrenholtz

et al. 2016

ACS Biomater. Sci. Eng.

View full text Add to dashboard Cite

show abstract

“…Backflow of infusate can be induced by tissue disruption, high infusion rates, and large catheter diameter [59]. The disappointing outcome of the PRECISE trial, which compared the efficacy of CED of citredekin besudotox with Gliadel® wafers, has been attributed to inadequate distribution likely due to suboptimal catheter placement [60–62]. Considerable progress is being made in the area of catheter design, especially the development of multi-port catheters [7] and implantable systems that can be used for multiple infusions [63].…”

Section: Challenges With Convection-enhanced Deliverymentioning

confidence: 99%

Nanomaterials for convection-enhanced delivery of agents to treat brain tumors

Seo

Saltzman

2017

Current Opinion in Biomedical Engineering

View full text Add to dashboard Cite

Nanomaterials represent a promising and versatile platform for the delivery of therapeutics to the brain. Treatment of brain tumors has been a long-standing challenge in the field of neuro-oncology. The current standard of care – a multimodal approach of surgery, radiation and chemotherapy – yields only a modest therapeutic benefit for patients with malignant gliomas. A major obstacle for treatment is the failure to achieve sufficient delivery of therapeutics at the tumor site. Recent advances in local drug delivery techniques, along with the development of highly effective brain-penetrating nanocarriers, have significantly improved treatment and imaging of brain tumors in preclinical studies. The major advantage of this combined strategy is the ability to optimize local therapy, by maintaining an effective and sustained concentration of therapeutics in the brain with minimal systemic toxicity. This review highlights some of the latest developments, significant advancements and current challenges in local delivery of nanomaterials for the treatment of brain tumors.

show abstract

“…Intracranial drug administration via CED may also potentially overcome systemic toxicities. In particular, catheter design and placement-in are critical components of any CED protocol (34). However, early studies may have been limited by "first generation" delivery techniques and recently reported improvements may potentially allow for better outcomes (26).…”

Section: Convection-enhanced Deliverymentioning

confidence: 99%

Advances in drug delivery to high grade gliomas

Fròsina

2016

Brain Pathology

View full text Add to dashboard Cite

If cancer is hard to be treated, brain cancer is even more, caused by the inability of many effective drugs given systemically to cross the blood brain and blood tumor barriers and reach adequate concentrations at the tumor sites. Effective delivery of drugs to brain cancer tissues is thus a necessary, albeit not sufficient, condition to effectively target the disease. In order to analyze the current status of research on drug delivery to high grade gliomas (HGG-WHO grades III and IV), the most frequent and aggressive brain cancers, a literature search was conducted in PubMed using the terms: "drug delivery and brain tumor" over the publication year 2015. Currently explored drug delivery techniques for HGG include the convection and permeabilization-enhanced deliveries, drug-releasing depots and Ommaya reservoirs. The efficacy/safety ratio widely varies among these techniques and the success of current efforts to increase this ratio widely varies as well.

show abstract

Current status of intratumoral therapy for glioblastoma

Cited by 42 publications

References 46 publications

Photothermal Therapy of Glioblastoma Multiforme Using Multiwalled Carbon Nanotubes Optimized for Diffusion in Extracellular Space

Photothermal Therapy of Glioblastoma Multiforme Using Multiwalled Carbon Nanotubes Optimized for Diffusion in Extracellular Space

Nanomaterials for convection-enhanced delivery of agents to treat brain tumors

Advances in drug delivery to high grade gliomas

Contact Info

Product

Resources

About