Current Status of Intrathecal Radiogold in the Treatment of Medulloblastoma

Gold, Lawrence H. A.; Kieffer, Stephen A.; D’Angio, Giulio J.; Fallon, Valerie; Long, Donlin M.

doi:10.3109/02841867209130756

Cited by 10 publications

(2 citation statements)

References 7 publications

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“…The complex causes leading to the production of the cauda equina syndrome by the use of intrathecal radiogold in the treatment of medulloblastoma are discussed by Gold et al(1972). In our cases, obviously the use of intrathecal CROP would be the main factor that could account for the development of this complication; however, in our patients this was not investigated.…”

Section: Willoughbymentioning

confidence: 72%

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Remission Maintenance Therapy for Meningeal Leukaemia: Intrathecal Methotrexate and Dexamethasone versus Intrathecal Craniospinal Irradiation with a Radiocolloid

Muriel¹,

Schere²,

Barengols³

et al. 1976

Br J Haematol

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Thirty-two patients with meningeal leukaemia who achieved meningeal remission with intrathecal methotrexate (MTX) plus dexamethasone (DMT) were entered in a randomized study of two maintenance treatments: (a) I6 patients received intermittent intrathecal doses of MTX plus DMT, and (b) I6 patients received intermittent intrathecal doses of radioactive chromic phosphate (CROP). The population and clinical characteristics of the cases assigned to each maintenance regimen were similar. The duration of meningeal remission was 55-600 + d (median 550 d) for the MTX and DMT group and 56-555 d (median 360 d) for the CROP group. There was no statistical difference (P greater than 0.05) between the curves of the two groups. Intrathecal CROP seems to be as effective as intrathecal MTX plus DMT as maintenance treatment for intrathecal MTX plus DMT induced meningeal remission. Further uses of this compound should be explored but it seems to be dangerous to administer it by lumbar puncture.

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Section: Willoughbymentioning

confidence: 72%

“…Currently, she has a meningeal relapse and is being reinduced with intrathecal MTX-DMT, but the neurological sequela is still present. None of these three patients had had previous radiation to the lumbar sacral spine or a myelogram performed, both factors known to contribute to the production of the cauda equina syndrome (Gold et al, 1972).…”

Section: Toxicitymentioning

confidence: 99%

Remission Maintenance Therapy for Meningeal Leukaemia: Intrathecal Methotrexate and Dexamethasone versus Intrathecal Craniospinal Irradiation with a Radiocolloid

Muriel¹,

Schere²,

Barengols³

et al. 1976

Br J Haematol

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Chemotherapy of primary malignant brain tumors in children

Shapiro

1975

Cancer

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Meningosis prophylaxis with intrathecal198Au-colloid and methotrexate in childhood acute lymphocytic leukemia

Metz

Stoll

Plenert

1982

Cancer

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Since 1972, telecobalt irradiation plus intrathecal methotrexate (ITMTX) has been successfully replaced in Jena by intrathecal colloidal radioactive gold (198Au) plus ITMTX for meningosis prophylaxis in leukemia. Seventy-three children with acute lymphocytic leukemia (ALL) were given 1.24-4.89 mCi (45.8-181 MBq) of colloidal 198Au IT after successful initiation of remission. During cytostatic therapy, the following relapses occurred: meningosis leucaemica, five patients (6.8%); bone-marrow relapse and the meningosis leucaemica, one patient; and bone-marrow relapse, 20 patients (27.4%). In 18 children, combination chemotherapy was terminated after two and a half or three years of treatment. After that time, one meningeal relapse and six bone-marrow relapses occurred. Within the first 24 hours after application of radioactive gold, headaches, vomiting, and fever occurred in less than 10% of the children. An apathy syndrome, leukecephalopathy, or severe infections, were not observed in a single case. Radioactive gold spreads in the subarachnoid space and is phagocytized by the arachnoidea. The tumoricide effect extends selectively over the space of distribution of the latent meningosis leucaemia. The cerebral parenchyma remains unaffected by radiation. Thus, radioactive gold may be preferable to telecobalt irradiation in preventing central nervous system leukemia.

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Current Status of Intrathecal Radiogold in the Treatment of Medulloblastoma

Cited by 10 publications

References 7 publications

Remission Maintenance Therapy for Meningeal Leukaemia: Intrathecal Methotrexate and Dexamethasone versus Intrathecal Craniospinal Irradiation with a Radiocolloid

Remission Maintenance Therapy for Meningeal Leukaemia: Intrathecal Methotrexate and Dexamethasone versus Intrathecal Craniospinal Irradiation with a Radiocolloid

Chemotherapy of primary malignant brain tumors in children

Meningosis prophylaxis with intrathecal198Au-colloid and methotrexate in childhood acute lymphocytic leukemia

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