Current status of indoor dust PBDE pollution and its physical burden and health effects on children

Zheng, Keyang; Zeng, Zhijun; Lin, Youping; Wang, Qihua; Tian, Qianwen; Huo, Xia

doi:10.1007/s11356-022-24723-w

Cited by 7 publications

(4 citation statements)

References 75 publications

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“…It is well documented that exposure to BFRs and their metabolites can induce neurodevelopmental effects such as lower IQ, impaired cognition, and behavior issues [ 62 , 63 , 64 ]. Within the DNT battery, BDE-47 was the most potent of all FRs but only due to the NFA being about 200 times more sensitive than the other DNT battery assays that otherwise had similar BMCs for all FRs.…”

Section: Discussionmentioning

confidence: 99%

Integrated Approach for Testing and Assessment for Developmental Neurotoxicity (DNT) to Prioritize Aromatic Organophosphorus Flame Retardants

Kreutz,

Oyetade,

Chang

et al. 2024

Toxics

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Organophosphorus flame retardants (OPFRs) are abundant and persistent in the environment but have limited toxicity information. Their similarity in structure to organophosphate pesticides presents great concern for developmental neurotoxicity (DNT). However, current in vivo testing is not suitable to provide DNT information on the amount of OPFRs that lack data. Over the past decade, an in vitro battery was developed to enhance DNT assessment, consisting of assays that evaluate cellular processes in neurodevelopment and function. In this study, behavioral data of small model organisms were also included. To assess if these assays provide sufficient mechanistic coverage to prioritize chemicals for further testing and/or identify hazards, an integrated approach to testing and assessment (IATA) was developed with additional information from the Integrated Chemical Environment (ICE) and the literature. Human biomonitoring and exposure data were identified and physiologically-based toxicokinetic models were applied to relate in vitro toxicity data to human exposure based on maximum plasma concentration. Eight OPFRs were evaluated, including aromatic OPFRs (triphenyl phosphate (TPHP), isopropylated phenyl phosphate (IPP), 2-ethylhexyl diphenyl phosphate (EHDP), tricresyl phosphate (TMPP), isodecyl diphenyl phosphate (IDDP), tert-butylphenyl diphenyl phosphate (BPDP)) and halogenated FRs ((Tris(1,3-dichloro-2-propyl) phosphate (TDCIPP), tris(2-chloroethyl) phosphate (TCEP)). Two representative brominated flame retardants (BFRs) (2,2′4,4′-tetrabromodiphenyl ether (BDE-47) and 3,3′,5,5′-tetrabromobisphenol A (TBBPA)) with known DNT potential were selected for toxicity benchmarking. Data from the DNT battery indicate that the aromatic OPFRs have activity at similar concentrations as the BFRs and should therefore be evaluated further. However, these assays provide limited information on the mechanism of the compounds. By integrating information from ICE and the literature, endocrine disruption was identified as a potential mechanism. This IATA case study indicates that human exposure to some OPFRs could lead to a plasma concentration similar to those exerting in vitro activities, indicating potential concern for human health.

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Section: Discussionmentioning

confidence: 99%

Integrated Approach for Testing and Assessment for Developmental Neurotoxicity (DNT) to Prioritize Aromatic Organophosphorus Flame Retardants

Kreutz,

Oyetade,

Chang

et al. 2024

Toxics

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“…For example, polybrominated chemicals have been widely used as flame retardants, while triazoles (steroid synthesis inhibitors) are fungicides intended for wood preservation. Substances identified as ED are subject to restrictions, but they can persist in materials and consequently in indoor dust [ 21 ]. For example, the exposure to polybrominated diphenyl ethers used in paints, plastics, foam furniture padding, textiles, rugs, curtains, televisions, building materials, airplanes, and automobiles, banned since 2006, may cause concerns for human health.…”

Section: Main Textmentioning

confidence: 99%

The impact of indoor air pollution on children’s health and well-being: the experts’ consensus

Bozzola,

Agostiniani,

Pacifici Noja

et al. 2024

Ital J Pediatr

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Background Pollution of the indoor environment represents a concern for human health, mainly in case of prolonged exposure such as in the case of women, children, the elderly, and the chronically ill, who spend most of their time in closed environments. Main body The aim of the study is to organize a group of experts in order to evaluate the evidence and discuss the main risk factors concerning indoor air and the impact on human health as well as challenging factors regarding preventive strategies to reduce pollution. The experts highlighted the main risk factors concerning indoor air, including poor ventilation, climatic conditions, chemical substances, and socio-economic status. They discussed the impact on human health in terms of mortality and morbidity, as well as challenging factors regarding preventive strategies to reduce pollution. Conclusion The experts identified strategies that can be reinforced to reduce indoor pollution and prevent negative consequences on human health at national and local levels.

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“…This concept implies that no effect can be detected for exposures below the lowest-observed-adverse-effect level (LOAEL). However, as chemicals able to disrupt the endogenous hormonal activities, PBDEs may be characterized by a non-linear, non-monotonic dose-response (NMDR) relationship (see Figure 2) [17] and by effects observed below the LOAEL (14,15).…”

Section: Dose-response and Time-exposure Curvesmentioning

confidence: 99%

“…In toddlers, who ingest more dust than adults, the indoor PBDE exposure is concerning [13]. In fact, children's exposure to indoor dust is a greater source of PBDEs than diet [14]. In infants, breastfeeding may become an additional route of PBDE absorption [15].…”

Section: Dose-response and Time-exposure Curvesmentioning

confidence: 99%

Polybrominated Diphenyl Ethers (PBDEs) and Human Health: Effects on Metabolism, Diabetes and Cancer

Renzelli,

Gallo,

Morviducci

et al. 2023

Cancers

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There is increasing evidence of the role of endocrine disruptors (EDs) derived from commonly employed compounds for manufacturing and processing in altering hormonal signaling and function. Due to their prolonged half-life and persistence, EDs can usually be found not only in industrial products but also in households and in the environment, creating the premises for long-lasting exposure. Polybrominated diphenyl ethers (PBDEs) are common EDs used in industrial products such as flame retardants, and recent studies are increasingly showing that they may interfere with both metabolic and oncogenic pathways. In this article, a multidisciplinary panel of experts of the Italian Association of Medical Diabetologists (AMD), the Italian Society of Diabetology (SID), the Italian Association of Medical Oncology (AIOM), the Italian Society of Endocrinology (SIE) and the Italian Society of Pharmacology (SIF) provides a review on the potential role of PBDEs in human health and disease, exploring both molecular and clinical aspects and focusing on metabolic and oncogenic pathways.

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Current status of indoor dust PBDE pollution and its physical burden and health effects on children

Cited by 7 publications

References 75 publications

Integrated Approach for Testing and Assessment for Developmental Neurotoxicity (DNT) to Prioritize Aromatic Organophosphorus Flame Retardants

Integrated Approach for Testing and Assessment for Developmental Neurotoxicity (DNT) to Prioritize Aromatic Organophosphorus Flame Retardants

The impact of indoor air pollution on children’s health and well-being: the experts’ consensus

Polybrominated Diphenyl Ethers (PBDEs) and Human Health: Effects on Metabolism, Diabetes and Cancer

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