Current status of Indian medicinal plants with antidiabetic potential: a review

Patil, Raju N; Patil, Ravindra; Ahirwar, Bharati; Ahirwar, Dheeraj

doi:10.1016/s2221-1691(11)60175-5

Cited by 73 publications

(46 citation statements)

References 73 publications

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“…Therefore, it is highly recommended to find new anti-diabetic molecules that stimulate glucose uptake by fat or muscle cells but distinct than thiazolidinediones or insulin mode of action. Also, ideally these novel drugs would not induce obesity or other side effects like brain damage, swelling, erythema, hepatotoxicity, and gastrointestinal disturbances (Sheng and Yang, 2008;Patil et al 2011).…”

Section: Introductionmentioning

confidence: 99%

Effect of Glycosin alkaloid from Rhizophora apiculata in non-insulin dependent diabetic rats and its mechanism of action: In vivo and in silico studies

2016

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Section: Introductionmentioning

confidence: 99%

Effect of Glycosin alkaloid from Rhizophora apiculata in non-insulin dependent diabetic rats and its mechanism of action: In vivo and in silico studies

2016

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“…[7] Diabetes mellitus occurs throughout the world, but most cases are found in the more developed countries. The greatest increase in prevalence is, however, expected to occur in Asia and Africa, where most patients will likely be found by 2030.…”

Section: Introductionmentioning

confidence: 99%

Nutraceuticals as therapeutic agents for holistic treatment of diabetes

Baldi¹,

Choudhary²,

Kumar³

2013

Int J Green Pharm

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Nutraceuticals is one of the promising approaches for prevention and treatment of a large number of ailments. Nutrients, herbals and dietary supplements are major constituents of nutraceuticals, which make it instrumental in maintaining health, acting against various diseased conditions and thus to promote the quality of life. Diabetes mellitus is one of them. It is a multi-factorial metabolic disorder reflected by high blood sugar/glucose level. In spite of significant development in drug discovery to treat this disease, extensive efforts are on for finding a holistic approach by combining compounds from natural and synthetic drugs. Botanicals, vitamins, anti-oxidants, minerals, amino acids and fatty acids, collectively referred as 'nutraceuticals' , are important sources of new therapies for type 2 diabetes and insulin resistance. This review summarises nutraceuticals with proven anti-diabetic potential in pre-clinical and clinical studies and explores the possibility of a new approach, 'polypathy' for synergistic management of diabetes.

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“…This assertion is further validated by the report of Zhang et al [16] which associated gene mutation in glucokinase with a form of diabetes known as maturity onset diabetes of the young. Compounds that elicit stimulatory effect on the activity of glucokinase have been reported to enhance the regulatory function of the enzyme in drug-induced diabetes in animal model [28,29].…”

Section: Discussionmentioning

confidence: 99%

“…Interestingly, Patil et al [29] had previously identified amentoflavone as the antidiabetic principle in Biophytum sensitivum, a plant well known for its antidiabetic function. Hence, the presence of the flavonoid in S. ellipcitum is likely responsible for its significant effects on glucose metabolizing enzymes such as glucokinase and glucose-6-phosphatase, as noted in the present study.…”

Section: Discussionmentioning

confidence: 99%