Current status of IBD and surgery of Crohn's disease in Thailand

Abstract

Inflammatory bowel disease (IBD) consists of two diseases: ulcerative colitis (UC) and Crohn's disease (CD). The incidence of IBD is much higher in Western countries compared to Asian countries, especially in Thailand. The incidence of UC in Thailand is quite low and seems less aggressive than in Western countries. Over the past two decades, the evolution of UC management in Thailand has led to a reduction in hospitalization and colectomy rate. Regarding CD, the majority of patients have an inflammatory phenotype at diagnosis. Diagnosis of CD remains challenging in Thailand as the time from onset of symptoms to diagnosis is quite delayed, possibly due to unawareness and difficulty in the differential diagnosis between CD and other infectious entero‐colitis such as intestinal tuberculosis. With a significant trend to early initiation of immunomodulators and biologics, the cumulative rate of surgery after diagnosis has been improved. To improve the outcomes of CD treatment in Thailand, physicians need more awareness to recognize the disease, which results in early diagnosis, prevention of long‐term complications, and reduction in the rate of surgery.

RSim: A Reference-Based Normalization Method via Rank Similarity

“…This discovery is consistent with previous results indicating that Bacteroidota, Firmicutes, Actinobacteriota, and Fusobacteriota are associated with obesity and that the obesity rate is significantly higher for immigrants than for people living in Thailand (Ley et al, 2006;Turnbaugh et al, 2009;Andoh et al, 2016). Furthermore, Desulfobacterota is shown to be related to inflammatory bowel diseases (Loubinoux et al, 2002), and the incidence of these diseases is much higher in Western countries compared to Asian countries, especially Thailand (Riansuwan and Limsrivilai, 2021), which is also consistent with our findings. These results again suggest that RSim normalization can improve the ability of differential abundance tests to control false discoveries and detect significant differences more effectively than existing normalization methods.…”

Perioperative optimization of Crohn's disease

“…Current reports have indicated that surgery rates at 1 and 5 years in the postbiologic era are lower than those recorded in the prebiologic era (14.8% and 31.2% vs. 12.6% and 24.2%, respectively) 11,12 . Although no direct comparison has been made between Eastern and Western countries, the surgical rate is either compatible 13,14 or less in Eastern countries than that in Western countries 15,16 …”

“… 11 , 12 Although no direct comparison has been made between Eastern and Western countries, the surgical rate is either compatible 13 , 14 or less in Eastern countries than that in Western countries. 15 , 16 …”

“…11,12 Although no direct comparison has been made between Eastern and Western countries, the surgical rate is either compatible 13,14 or less in Eastern countries than that in Western countries. 15,16 During the past decade, several population-based studies have assessed the temporal trends of CD surgery, but results have been conflicting. 12,17 In a Swedish population-based database study, the cumulative incidence of the first abdominal surgical procedure following a CD diagnosis decreased by two-thirds over the past 25 years, whereas the rate of repeat surgery has remained stable despite the introduction of biological therapy.…”

Enhanced Oral Bioavailability of MT-102, a New Anti-inflammatory Agent, via a Ternary Solid Dispersion Formulation

“…Inflammatory bowel diseases (IBD), such as Crohn’s disease and ulcerative colitis, are chronic recurrent intestinal disorders characterized by transmural granulomatous inflammation or mucosa and submucosa inflammation [ 1 ]. Although the exact cause of IBD is unknown, genetic factors, host intestinal flora, and the host immune system may play a role in IBD pathogenesis [ 2 ].…”