Current Status of Genetically Engineered Pig to Monkey Kidney Xenotransplantation in Korea

Hwang, Sun Ae; Park, Kyoung Sik; Kim, Wan Seop; Shin, Ki Cheul; Ahn, Yu Rim; Kim, Jun Seok; Chee, Hyun Keun; Yang, Hyun Suk; Oh, Keon Bong; Choi, Ki Myung; Hwang, Jeong Ho; Hur, Chang-Gi; Yun, Ik Jin

doi:10.1016/j.transproceed.2023.03.060

Cited by 2 publications

(2 citation statements)

References 23 publications

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“…Despite the challenges, unwavering efforts are in progress to advance the field of xenotransplantation toward clinical trials, buoyed by the continued promising outcomes observed in preclinical trials for xenografts 17 . A recent study reviewed xenotransplantation clinical activities as of December 2022, revealing that out of 14 activities, only nine used porcine xenografts 18 .…”

Section: Regulationmentioning

confidence: 99%

“…In South Korea, donor αGal‐knockout ‐based transgenic pig kidneys were utilized, featuring knock‐in genes of CD39, CD46, CD55, CD73, and thrombomodulin, along with two to four additional transgenic modifications. These modifications were tested in a non‐human primate (NHP) model, and the grafts demonstrated survival for a median duration of 39 days, with the longest survival lasting 115 days 17 …”

Section: Modifications To the Xenograftmentioning

confidence: 99%

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Xenotransplantation literature update March 2023–November 2023

Kamberi,

Meier

2024

Xenotransplantation

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Section: Regulationmentioning

confidence: 99%

Section: Modifications To the Xenograftmentioning

confidence: 99%

Xenotransplantation literature update March 2023–November 2023

Kamberi,

Meier

2024

Xenotransplantation

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Physiological basis for xenotransplantation from genetically modified pigs to humans

Peterson,

Yacoub,

Ayares

et al. 2024

Physiological Reviews

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The collective efforts of scientists over multiple decades have led to advancements in molecular and cellular biology-based technologies including genetic engineering and animal cloning, that are now being harnessed to enhance the suitability of pig organs for xenotransplantation into humans. Using organs sourced from pigs with multiple gene deletions and human transgene insertions, investigators have overcome formidable immunological and physiological barriers in pig-to-non-human primate (NHP) xenotransplantation and achieved prolonged pig xenograft survival. These studies informed the design of Revivicor's (Revivicor Inc, Blacksburg, VA) genetically engineered pig with 10 genetic modifications (10 GE) (including the inactivation of 4 endogenous porcine genes and insertion of 6 human transgenes) whose hearts and kidneys have now been studied in preclinical human xenotransplantation models using brain-dead recipients. Additionally, the first two clinical cases of pig-to-human heart xenotransplantation were recently performed using hearts from this 10 GE pig at the University of Maryland. While this review focuses on xenotransplantation of hearts and kidneys, multiple organs, tissues, and cell-types from genetically engineered pigs will provide much-needed therapeutic interventions in the future.

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Current Status of Genetically Engineered Pig to Monkey Kidney Xenotransplantation in Korea

Cited by 2 publications

References 23 publications

Xenotransplantation literature update March 2023–November 2023

Xenotransplantation literature update March 2023–November 2023

Physiological basis for xenotransplantation from genetically modified pigs to humans

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