Current Status of Functional Pulmonary Imaging1

Permutt, Solbert

doi:10.1016/j.acra.2005.08.025

Cited by 3 publications

(3 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1A): 1) A blood compartment accounting for the amount of 18 F-FDG that is confined to the pulmonary vessels (C p (t)F B ), where F B is the fractional volume of pulmonary blood; 2) an extravascular compartment representing the concentration of 18 F-FDG in the ROI that constitutes the precursor pool for phosphorylation to 18 F-FDG-6-P (C e (t)); 3) an extravascular/non-cellular compartment, which accounts for the concentration of 18 F-FDG in the ROI that is not an immediate precursor for phosphorylation (C ee (t)); and 4) a metabolite compartment accounting for the ROI concentration of 18 F-FDG-6-P (C m (t)). The activity concentration in the region of interest (C ROI (t)) is given as (1) According to Figure 1A, facilitated 18 F-FDG transport from blood into the tissue, per unit of lung volume, is quantified by the rate constant k 1 (see Appendix). The rate constant k 2 quantifies tracer transport from tissue back into the blood, and k 3 is the rate of 18 F-FDG phosphorylation to 18 F-FDG-P, which is proportional to hexokinase activity.…”

Section: Model Of Lung 18 F-fdg Kinetics During Acute Lung Injury: Twmentioning

confidence: 99%

“…In basic science and clinical investigation of lung pathology, there is a growing interest in new pulmonary imaging techniques (1)(2)(3). Recently, PET imaging of the glucose analog 2-deoxy-2-[ 18 F]fluoro-D-glucose ( 18 F-FDG), a standard tool in oncology, is increasingly used to assess metabolic activity of pulmonary inflammatory cells (4)(5)(6)(7)(8)(9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Modeling Pulmonary Kinetics of 2-Deoxy-2-[18F]fluoro-d-glucose During Acute Lung Injury

et al. 2008

View full text Add to dashboard Cite

Rationale and objectives-Dynamic positron-emission tomography (PET) imaging of the radiotracer 2-deoxy-2-[18F]fluoro-D-glucose ( 18 F-FDG) is increasingly used to assess metabolic activity of lung inflammatory cells. To analyze the kinetics of 18 F-FDG in brain and tumor tissues the 'Sokoloff' model has been typically used. In the lungs, however, a high blood-to-parenchymal volume ratio and 18 F-FDG distribution in edematous injured tissue could require a modified model to properly describe 18 F-FDG kinetics.Material and Methods-We developed and validated a new model of lung 18 F-FDG kinetics that includes an extravascular/non-cellular compartment in addition to blood and 18 F-FDG precursor pools for phosphorylation. Parameters obtained from this model were compared with those obtained using the Sokoloff model. We analyzed dynamic PET data from 15 sheep with smoke or ventilatorinduced lung injury.Results-In the majority of injured lungs, the new model provided better fit to the data than the Sokoloff model. Rate of pulmonary 18 F-FDG net uptake and distribution volume in the precursor pool for phosphorylation correlated between the two models (R 2 = 0.98, 0.78), but were overestimated with the Sokoloff model by 17% (p < 0.05) and 16% (p < 0.0005) as compared to the new one. The range of the extravascular/non-cellular 18 F-FDG distribution volumes was up to 13% and 49% of lung tissue volume in smoke and ventilator-induced lung injury, respectively. Conclusion-The lung-specific model predicted 18 F-FDG kinetics during acute lung injury more accurately than the Sokoloff model and may provide new insights in the pathophysiology of lung injury.

show abstract

Section: Model Of Lung 18 F-fdg Kinetics During Acute Lung Injury: Twmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Modeling Pulmonary Kinetics of 2-Deoxy-2-[18F]fluoro-d-glucose During Acute Lung Injury

et al. 2008

View full text Add to dashboard Cite

show abstract

“…Functional imaging in the lungs has great potential for mechanistic studies of lung disease, particularly for identifying regional patterns of obstruction that test physiologic hypotheses (4)(5)(6)(7). Regional mosaics of reduced parenchymal density, apparently due to air trapping, are associated with asthma on computed tomography (CT) (8).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Structure-Function Relationships in Asthma using Multidetector CT and Hyperpolarized He-3 MRI

et al. 2008

View full text Add to dashboard Cite

Rationale and Objectives-While multiple detector CT (MDCT) and hyperpolarized gas MRI (HP MRI) have demonstrated ability to detect structural and ventilation abnormalities in asthma, few studies have sought to exploit or cross-validate the regional information provided by these techniques. The purpose of this work is to assess regional disease in asthma by evaluating the association of sites of ventilation defect on HP MRI with other regional markers of airway disease, including air trapping on MDCT and inflammatory markers on bronchoscopy.Materials and Methods-Both HP MRI using helium-3 and MDCT were acquired in the same patients. Supervised segmentation of the lung lobes on MRI and MDCT facilitated regional comparisons of ventilation abnormalities in the lung parenchyma. The percentage of spatial overlap was evaluated between regions of ventilation defect on HP MRI and hyperlucency on MDCT to determine associations between obstruction and likely regions of gas trapping.. Similarly, lung lobes with high defect volume were compared to lobes with low defect volume for differences in inflammatory cell number and percentage using bronchoscopic assessment.Results-There was significant overlap between sites of ventilation defect on HP MRI and hyperlucency on MDCT suggesting that sites of airway obstruction and air trapping are associated in asthma. The percent (r = 0.68; p = 0.0039) and absolute (r = 0.61; p = 0.0125) number of neutrophils on bronchoalveolar lavage (BAL) for the sampled lung lobe also directly correlated with increased defect volume.Conclusion-These results show promise for using image guidance to assess specific regions of ventilation defect or air trapping in heterogeneous obstructive lung diseases such as asthma.

show abstract

What Can We Learn From Success?

Baum¹

2006

Academic Radiology

View full text Add to dashboard Cite

Current Status of Functional Pulmonary Imaging1

Cited by 3 publications

References 54 publications

Modeling Pulmonary Kinetics of 2-Deoxy-2-[18F]fluoro-d-glucose During Acute Lung Injury

Modeling Pulmonary Kinetics of 2-Deoxy-2-[18F]fluoro-d-glucose During Acute Lung Injury

Evaluation of Structure-Function Relationships in Asthma using Multidetector CT and Hyperpolarized He-3 MRI

What Can We Learn From Success?

Contact Info

Product

Resources

About