Current status of esophageal cancer treatment

Triantafyllou, Tania; Wijnhoven, Bas P. L.

doi:10.21147/j.issn.1000-9604.2020.03.01

Cited by 16 publications

(12 citation statements)

References 109 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The treatment of esophageal cancer mainly includes surgery, radiotherapy, chemotherapy, targeted therapy and so on. Despite recent advances in the treatment of esophageal cancer, the prognosis for esophageal cancer remains relatively poor ( 49 , 50 ). In recent years, immunotherapy for EC has attracted increasing attention, and various clinical studies have been performed ( 51 , 52 ).…”

Section: Discussionmentioning

confidence: 99%

METTL3 Is Associated With the Malignancy of Esophageal Squamous Cell Carcinoma and Serves as a Potential Immunotherapy Biomarker

Zhou

Guo

et al. 2022

Front. Oncol.

View full text Add to dashboard Cite

Methyltransferase-like 3 (METTL3) is an RNA methyltransferase mediating N6 methyladenosine (m6A) modification. Its role in cancer pathogenesis and progression has attracted increasing attention. However, the immunological role, possible immune mechanism, and clinical significance of METTL3 in esophageal squamous cell carcinoma (ESCC) remain to be confirmed. The Tumor Genome Atlas (TCGA) provided clinical and transcriptome sequencing data for this study (162 tumor tissue samples and 11 normal tissue samples), while the Immunology Database and Analysis Portal (immport, https://www.immport.org/home) provided 2483 immune-related genes. METTL3 was substantially expressed in ESCC and linked to poor prognosis in ESCC, according to the findings. Functional analysis revealed that METTL3 is mainly involved in chromosomal homologous recombination and DNA mismatch repair processes, which could be potential mechanisms for tumor disease development and progression. Analysis on the TISIDB website shows that effector memory CD8 T cells, NK cells, neutrophils and other cells are highly correlated with METTL3 expression. We screened immune genes associated with METTL3 by Spearman’s analysis and performed functional analysis. These immune genes were mostly linked with immune processes, such as cytokine receptors, the MAPK signaling pathway, and natural killer cell-mediated cytotoxicity, indicating that METTL3 is a key molecule in the immune regulation of esophageal cancer. In addition, based on METTL3-related immune genes, we separated the patients into several subgroups and constructed a prognostic prediction model consisting of six immune genes. As an independent prognostic indicator for ESCC, the risk score of this model can be employed. A nomogram was also developed to accurately evaluate individual prognoses based on clinical indicators and risk scores. In summary, this study suggests that METTL3 is not only a potential pathogenic molecule for esophageal carcinogenesis and progression but also a potential biological marker for forecasting ESCC patient prognosis and could serve as a basis for clinical decision making.

show abstract

Section: Discussionmentioning

confidence: 99%

METTL3 Is Associated With the Malignancy of Esophageal Squamous Cell Carcinoma and Serves as a Potential Immunotherapy Biomarker

Zhou

Guo

et al. 2022

Front. Oncol.

View full text Add to dashboard Cite

show abstract

“…Esophagectomy is still the main treatment, and some methods are being tried,such as endoscopic treatment for early EC, prophylactic chemoradiation, Perioperative treatment, targeted therapy and immunotherapy, etc. However, the choice of these treatments is affected by the type and stage of the disease, tumor location, individual differences of patients, and there is no global consensus on the optimal regimen [21] .…”

Section: Discussionmentioning

confidence: 99%

Qigesan Reduced the Migration and Invasion of Esophageal Cancer Cells via Inhibiting TGF-β1 Pathway

Shang

Zhu

Meng

et al. 2021

Preprint

View full text Add to dashboard Cite

Background: The present study aim to investigate the mechanism of Qigesan (QGS) on migration and invasion of esophageal cancer cells. Methods: First, we detected the cells in the normal group and the QGS group using microarray, and analyzed the ontology function and signaling pathway of target genes, and screened out TGF-β as one of the important targets of QGS. The subsequent verification experiments were divided into four groups: control group, model group (TGF-β1 stimulation group), QGS group (TGF-β1+QGS group) and positive control group (TGF-β1+TGF-β1 receptor inhibitor group). The migration and invasion abilities, as well as the expressions of related proteins and mRNA of each experimental group were detected. The migration and invasion ability of cells were detected by cell scratch test, and the Gene expression levels of E-cadherin, Vimentin, Smad2 and Smad7 mRNA in TGF-β1/Smad pathway were detected by RT-qPCR. The expression of E-cadherin, Vimentin, p-Smad2/3, Smad2/3 and Smad7 were detected by WB. Results: The results showed that TE-1 cells were reversed from fibroblast induced by TGF-β1 to epithelial cells after being treated QGS with the concentration of 20ug/mL for 36 h. Besides, QGS inhibited the migration and invasion of TE-1 cells and down-regulated the Gene and protein expression of Vimentin, Smad2 mRNA and Vimentin, p-Smad2/3 and Smad2/3. Meanwhile, The gene and protein overexpression E-cadherin and Smad7 was observed in QGS-treated cells. Conclusions: Together, these data indicated that QGS interfered with the epithelial-mesenchymal transition (EMT) process of TE-1 cells and reduced the migration and invasion of TE-1 cells via regulating TGF-β pathway, which maybe provided idea for the treatment of esophageal cancer.

show abstract

“…While esophagectomy remains the cornerstone, endoscopic procedures for early lesions, neoadjuvant chemoradiotherapy and minimally invasive esophagectomy have been successfully and widely used for clinical management of ESCC. [103][104][105] However, early lymphatic metastasis in some cases remains a challenge and makes outcomes unpredictable.…”

Section: Therapy For Esccmentioning

confidence: 99%

Research on esophageal cancer: With personal perspectives from studies in China and Kenya

Yang

Chen

2020

Intl Journal of Cancer

View full text Add to dashboard Cite

The most common form of esophageal cancer (EC), esophageal squamous cell carcinoma (ESCC), is prevalent in many unindustrialized societies, among people with lower socioeconomic status and those who frequently use tobacco and alcohol. In some areas, ESCC mortality ranked top among all cancer. In this review, we begin with discussions of the extensive research on EC in Linxian in northern China that started 60 years ago and the recent studies in Kenya from our personal perspectives.Based on the results obtained from these studies and information from the literature, we summarize our current understanding about the risk factors for ESCC including lifestyle factors (smoking, alcohol, consumption of food and beverages at high temperature and other unhealthy habits), poor diet and nutritional insufficiencies and genetic susceptibility. Elimination or minimization of these environmental risk factors, as well as early detection and treatment of precancerous lesions, would be effective means for the prevention of ESCC. Current knowledge of molecular alterations in ESCC (gene mutations, hypermethylation and amplification or overexpression), as well as treatment of ESCC and the potential of targeted therapy, are also discussed.Finally, we propose effective approaches for the prevention of ESCC by adapting a healthy lifestyle, including a healthy diet that would also prevent other diseases. Community outreach, public education and international collaboration are important for achieving this public health goal.

show abstract

Current status of esophageal cancer treatment

Cited by 16 publications

References 109 publications

METTL3 Is Associated With the Malignancy of Esophageal Squamous Cell Carcinoma and Serves as a Potential Immunotherapy Biomarker

METTL3 Is Associated With the Malignancy of Esophageal Squamous Cell Carcinoma and Serves as a Potential Immunotherapy Biomarker

Qigesan Reduced the Migration and Invasion of Esophageal Cancer Cells via Inhibiting TGF-β1 Pathway

Research on esophageal cancer: With personal perspectives from studies in China and Kenya

Contact Info

Product

Resources

About