Current Status of Antihypertensive Prescription and Associated Blood Pressure Control in Japan

Mori, Hisao; Ukai, Hiroshi; Yamamoto, Hareaki; Saitou, Saburo; Hirao, Kouich; Yamauchi, Mikio; Umemura, Satoshi

doi:10.1291/hypres.29.143

Cited by 125 publications

(111 citation statements)

References 29 publications

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“…Although the percentage of patients using diuretics in the present study was higher than that found in previous reports from Japan (3)(4)(5), the prescription rate of diuretics (8.6%) among patients with a history of stroke still seems to be low. In the Perindopril Protection against Recurrent Stroke study (PROGRESS), it was shown that combination therapy with an ACE-inhibitor (perindopril) and a diuretic (indapamide) appeared to reduce the risk of stroke (8).…”

Section: Number Of Diuretic Prescriptions (N)contrasting

confidence: 92%

“…The percentage of patients using diuretics (9.3%) in the J-HOME study was higher than that (4.0-5.4%) found in previous studies (3)(4)(5), but was similar to that found (12.6%) in another recent study (6). This trend could be attributable to the impact of recently published, large-scale intervention trials, such as the ALLHAT study, which emphasized the clinical significance of diuretics (1,16,17).…”

Section: Discussioncontrasting

confidence: 70%

“…*The percentage represented the propotion among patients treated with diuretics. previous studies showed a high prescription rate of CCBs for both monotherapy and combination therapy (5).…”

Section: Discussionmentioning

confidence: 96%

“…In Japan, it has been reported that the percentage of treated hypertensives being prescribed diuretics was only 4.0-5.4% for the period from 1999 to 2002 (3)(4)(5), but was 13.0-14.0% between 2003 and 2004 (6, 7). However, the dosages of diuretics used were not mentioned in these reports.…”

Section: Introductionmentioning

confidence: 99%

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Current Usage of Diuretics among Hypertensive Patients in Japan: The Japan Home versus Office Blood Pressure Measurement Evaluation (J-HOME) Study

et al. 2006

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In the Japan Home versus Office Blood Pressure Measurement Evaluation (J-HOME) study, we examined the current situation with respect to the prescription of diuretics, including the prevalence of diuretic treatment and the dosages used for patients with essential hypertension in primary care settings. Of the 3,400 hypertensive patients included in the study, 315 (9.3%) patients (mean age: 66.9 ± 10.4 years; males: 43.5%) were prescribed diuretics. Compared with patients who were not using diuretics, those who were using diuretics were more obese and had more complications. The most commonly prescribed diuretic among the 331 prescriptions in the 315 diuretic users was trichlormethiazide (44%), followed by indapamide (15%) and spironolactone (14%). Among patients being treated with diuretics, monotherapy was used in only 5% of patients; in the majority of patients combination therapy including diuretics (95%) was used. Relatively low dosages of diuretics were generally used. There was a difference between the actual dosages prescribed and those recommended by the Japanese Society of Hypertension (JSH) guidelines or the product information approved in Japan. Compared with previous estimates of the prevalence of diuretic use in hypertensives in Japan (4.0-5.4%), the rate in the J-HOME study (9.3%) was higher. This may be attributable at least in part

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Section: Number Of Diuretic Prescriptions (N)contrasting

confidence: 92%

Section: Discussioncontrasting

confidence: 70%

“…*The percentage represented the propotion among patients treated with diuretics. previous studies showed a high prescription rate of CCBs for both monotherapy and combination therapy (5).…”

Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Current Usage of Diuretics among Hypertensive Patients in Japan: The Japan Home versus Office Blood Pressure Measurement Evaluation (J-HOME) Study

et al. 2006

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“…In Japan, CCBs have long been the most widely used antihypertensives, mainly because of their reliable blood pressurelowering effects (13). ARBs are a relatively new class of drugs that suppress the renin-angiotensin system in a manner similar to ACE inhibitors.…”

Section: Introductionmentioning

confidence: 99%

Controlled Release Nifedipine and Valsartan Combination Therapy in Patients with Essential Hypertension: The Adalat CR and Valsartan Cost-Effectiveness Combination (ADVANCE-Combi) Study

Saito

Saruta

2006

Hypertens Res

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Hypertension management in diabetic patients: prescribing trends from 1999 to 2005 in three Japanese university hospitals

Kamijima

Ooba

Yagame

et al. 2008

Pharmacoepidemiology and Drug

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show abstract

Current Status of Antihypertensive Prescription and Associated Blood Pressure Control in Japan

Cited by 125 publications

References 29 publications

Current Usage of Diuretics among Hypertensive Patients in Japan: The Japan Home versus Office Blood Pressure Measurement Evaluation (J-HOME) Study

Current Usage of Diuretics among Hypertensive Patients in Japan: The Japan Home versus Office Blood Pressure Measurement Evaluation (J-HOME) Study

Controlled Release Nifedipine and Valsartan Combination Therapy in Patients with Essential Hypertension: The Adalat CR and Valsartan Cost-Effectiveness Combination (ADVANCE-Combi) Study

Hypertension management in diabetic patients: prescribing trends from 1999 to 2005 in three Japanese university hospitals

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