Current Status of Anabolic Steroids

Fruehan, Alice E.

doi:10.1001/jama.1963.03700200049009

Cited by 15 publications

(5 citation statements)

References 14 publications

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“…Anabolic therapy has been used in a variety of clinical conditions in which protein depletion is thought to be present (7). It is generally believed that underweight geriatric patients are protein‐depleted, and therefore anabolic steroids would be of value in their treatment.…”

Section: Discussionmentioning

confidence: 99%

A Vitamin, Anabolic, Stimulant Mixture. Is This Form of Medication Advantageous for Debilitated Geriatric Patients?

Johnson¹,

Shaw²

1966

J American Geriatrics Society

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Of 32 underweight geriatric patients in a double-blind study, 24 were given a therapeutic mixture containing, per dose, 10 mg of methylphenidate, 2.5 mg of methandrostenolone, and a mixture of B vitamins; 8 patients were given placebo only. After eight weeks of this therapy, there was a significant weight gain in the treated patients. In some cases, this was associated with increased bromsulphalein retention. The number of patients who showed clinically evident increases in strength and vitality was no greater than in the control group. The results lend no support to the use of tonic mixtures instead of separate drugs.

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Section: Discussionmentioning

confidence: 99%

A Vitamin, Anabolic, Stimulant Mixture. Is This Form of Medication Advantageous for Debilitated Geriatric Patients?

Johnson¹,

Shaw²

1966

J American Geriatrics Society

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“…A loading dosage followed by smaller dosages of an anabolic steroid (especially norbolethone) on an intermittent regimen is reported to produce a consistent weight gain with a reduced risk of hepatic dysfunction (4, 8). Therefore, in our series, the loading dosage of norbolethone was one 2.5‐mg tablet three times daily for the first week.…”

Section: Methodsmentioning

confidence: 99%

“…The fact that body weight may remain stable in the presence of an anabolic effect, or may increase in the presence of a non‐anabolic effect or concomitant illness indicates the need for quantitative measurement of the actions of anabolic agents; this has been pointed out by others (1, 4). The clinician often cannot conduct nitrogen balance studies, so he has to rely on changes in body weight as the primary criterion in determining the efficacy of treatment.…”

mentioning

confidence: 99%

Body Weight as an Index of Therapeutic Effect in Anabolic Steroid Therapy*

Wolpert

Sheppard

Merlis

1968

J American Geriatrics Society

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The efficacy of anabolic steroid therapy has often been challenged because of equivocal clinical evidence of weight gain. In view of this challenge, 21 chronically underweight, geriatric patients in a state hospital were chosen for a study to determine the effect of a new synthetic anabolic prep mation, norbolethone. Long-term weight charts were used to determine confidence limits. After a one-month placebo trial, placebo responders were identified; then the active preparation was given for fourteen weeks. The data indicated that 8pUriOU8 results can be obtained if strict criteria are not used for changes in body weight. Of the 21 etudy patients, as many as 18 could have been reported as showing a weight gain if only a short pre-study period had been used for the baseline. However, when the placebo responders and yearly weight fluctuations were accounted for, only 4 patients showed significant gains in weight, and only 2 of these maintained their gaine until the completfon' of the anabolic phase of the etudy.Unless stringent criteria are applied, gross body weight alone cannot be used as a reliable index of the therapeutic &ect of anabolic ste~oids.Problems in design and data handling have often made the study of the clinical effects of anabolic steroids difficult to evaluate. There is considerable information regarding the value of an anabolic stimulus in the management of chronic illness, and the nitrogen-retaining effect is well documented. However, the data on body weight gains are often equivocal (1-3).The fact that body weight may remain stable in the presence of an anabolic effect, or may increase in the presence of a non-anabolic effect or concomitant illness indicates the need for quantitative measurement of the actions of anabolic agents; this has been pointed out by others (1, 4). The clinician often cannot conduct nitrogen balance studies, so he has to rely on changes in body weight as the primary criterion in determining the efficacy of treatment. The literature is vague on this important criterion; weight gains are expressed as

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“…These may include liver toxicity, cardiovascular issues, hormonal imbalances and estrogenrelated effects. Additionally, the gains achieved with Methandrostenolone are often associated with water retention, which may not be purely attributed to lean muscle mass [16][17][18][19][20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Dianabol Unveiled: A Systematic Review of Methandrostenolone

Hamlaoui

2023

JOSR

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Methandrostenolone, commonly known as Dianabol or Dbol, is an anabolic steroid that gained immense popularity in the 20th century due to its potential to promote muscle growth and enhance athletic performance. Originally developed for medicinal purposes, it quickly found its way into the realms of bodybuilding and sports. This research article aims to provide an in-depth review of Methandrostenolone’s pharmacology, mechanisms of action, performance-enhancing effects, potential side effects and overall health implications. We explore the scientific evidence surrounding its use, the risks associated with its misuse and the legal status of Methandrostenolone in various countries.

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Current Status of Anabolic Steroids

Cited by 15 publications

References 14 publications

A Vitamin, Anabolic, Stimulant Mixture. Is This Form of Medication Advantageous for Debilitated Geriatric Patients?

A Vitamin, Anabolic, Stimulant Mixture. Is This Form of Medication Advantageous for Debilitated Geriatric Patients?

Body Weight as an Index of Therapeutic Effect in Anabolic Steroid Therapy*

Dianabol Unveiled: A Systematic Review of Methandrostenolone

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