Current status of 4D offline PET-based treatment verification at the Heidelberg Ion-Beam Therapy Center

Kurz, Christopher; Bauer, J.; Unholtz, Daniel; Gianoli, Chiara; Combs, Stephanie E.; Debus, Jürgen; Richter, Daniel; Kaderka, Robert; Bert, Christoph; Stützer, Kristin; Baroni, Guido; Parodi, Katia

doi:10.1109/nssmic.2013.6829303

Cited by 2 publications

(1 citation statement)

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“…In 4D treatment verification, the tumour motion during the irradiation and during the successive PET acquisition is taken into account. 29 However, with the standard reconstruction strategies, 4D PET-based treatment verification is nearly impossible for the prohibitively low counting statistics levels. Motion-aware reconstructions are therefore needed.…”

Section: Discussionmentioning

confidence: 99%

4D ML reconstruction as a tool for volumetric PET‐based treatment verification in ion beam radiotherapy

et al. 2016

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Section: Discussionmentioning

confidence: 99%

4D ML reconstruction as a tool for volumetric PET‐based treatment verification in ion beam radiotherapy

et al. 2016

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Vision 20/20: Positron emission tomography in radiation therapy planning, delivery, and monitoring

Parodi

2015

Medical Physics

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Positron emission tomography (PET) is increasingly considered as an effective imaging method to support several stages of radiation therapy. The combined usage of functional and morphological imaging in state-of-the-art PET/CT scanners is rapidly emerging to support the treatment planning process in terms of improved tumor delineation, and to assess the tumor response in follow-up investigations after or even during the course of fractionated therapy. Moreover, active research is being pursued on new tracers capable of providing different insights into tumor function, in order to identify areas of the planning volume which may require additional dosage for improved probability of tumor control. In this respect, major progresses in the next years will likely concern the development and clinical investigation of novel tracers and image processing techniques for reliable thresholding and segmentation, of treatment planning and beam delivery approaches integrating the PET imaging information, as well as improved multimodal clinical instrumentation such as PET/MR. But especially in the rapidly emerging case of ion beam therapy, the usage of PET is not only limited to the imaging of external tracers injected to the patient. In fact, a minor amount of positron emitters is formed in nuclear fragmentation reactions between the impinging ions and the tissue, bearing useful information for confirmation of the delivered treatment during or after therapeutic irradiation. Different implementations of unconventional PET imaging for therapy monitoring are currently being investigated clinically, and major ongoing research aims at new dedicated detector technologies and at challenging applications such as real-time imaging and time-resolved in vivo verification of motion compensated beam delivery. This paper provides an overview of the different areas of application of PET in radiation oncology and discusses the most promising perspectives in the years to come for radiation therapy planning, delivery, and monitoring.

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Current status of 4D offline PET-based treatment verification at the Heidelberg Ion-Beam Therapy Center

Cited by 2 publications

References 8 publications

4D ML reconstruction as a tool for volumetric PET‐based treatment verification in ion beam radiotherapy

4D ML reconstruction as a tool for volumetric PET‐based treatment verification in ion beam radiotherapy

Vision 20/20: Positron emission tomography in radiation therapy planning, delivery, and monitoring

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