Current Status and Trends of Antibacterial Resistance in China

Hu, Fupin; Zhu, Demei; Wang, Fu; Wang, Minggui

doi:10.1093/cid/ciy657

Cited by 250 publications

(242 citation statements)

References 8 publications

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“…Additionally, of the studies using an antibiotic, 2 of 9 focusing on Gram+ bacteria used strains already resistant to first-line antibiotics. Many infections are not dominated by resistant microbes, and GramÀ bacteria can have higher resistance profiles than Gram+ bacteria (Hu et al, 2018a). This choice could be influenced by media coverage, strain access or geographic location.…”

Section: Experimental Approachesmentioning

confidence: 99%

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Sonobactericide: An Emerging Treatment Strategy for Bacterial Infections

Lattwein

Shekhar

Kouijzer

et al. 2020

Ultrasound in Medicine & Biology

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Ultrasound has been developed as both a diagnostic tool and a potent promoter of beneficial bioeffects for the treatment of chronic bacterial infections. Bacterial infections, especially those involving biofilm on implants, indwelling catheters and heart valves, affect millions of people each year, and many deaths occur as a consequence. Exposure of microbubbles or droplets to ultrasound can directly affect bacteria and enhance the efficacy of antibiotics or other therapeutics, which we have termed sonobactericide. This review summarizes investigations that have provided evidence for ultrasound-activated microbubble or droplet treatment of bacteria and biofilm. In particular, we review the types of bacteria and therapeutics used for treatment and the in vitro and pre-clinical experimental setups employed in sonobactericide research. Mechanisms for ultrasound enhancement of sonobactericide, with a special emphasis on acoustic cavitation and radiation force, are reviewed, and the potential for clinical translation is discussed. (

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Section: Experimental Approachesmentioning

confidence: 99%

“…This choice could be influenced by media coverage, strain access or geographic location. All articles using vancomycin and methicillin-resistant microbes originated from China, which has high levels of reported antimicrobial resistance (Hu et al, 2018a).…”

Section: Experimental Approachesmentioning

confidence: 99%

Sonobactericide: An Emerging Treatment Strategy for Bacterial Infections

Lattwein

Shekhar

Kouijzer

et al. 2020

Ultrasound in Medicine & Biology

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“…The rise in global resistance to quinolones poses a great challenge to clinical treatment and public health, given the possible transmission of fluoroquinolone resistance from animals to humans [2]. In 2017, the resistance rate of Escherichia coli to ciprofloxacin was 57.0% in China [3].…”

Section: Introductionmentioning

confidence: 99%

Emerging coexistence of three PMQR genes on a multiple resistance plasmid with a new surrounding genetic structure of qnrS2 in E. coli in China

Ying

Zhou

Xie

et al. 2020

Antimicrob Resist Infect Control

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Background: Quinolones are commonly used for treatment of infections by bacteria of the Enterobacteriaceae family. However, the rising resistance to quinolones worldwide poses a major clinical and public health risk. This study aimed to characterise a novel multiple resistance plasmid carrying three plasmid-mediated quinolone resistance genes in Escherichia coli clinical stain RJ749. Methods: MICs of ceftriaxone, cefepime, ceftazidime, ciprofloxacin, and levofloxacin for RJ749 and transconjugant c749 were determined by the Etest method. Conjugation was performed using sodium azide-resistant E. coli J53 strain as a recipient. The quinolone resistance-determining regions of gyrA, gyrB, parC, and parE were PCR-amplified. Results: RJ749 was highly resistant to quinolones, while c749 showed low-level resistance. S1-nuclease pulsed-field gel electrophoresis revealed that RJ749 and c749 both harboured a plasmid. PCR presented chromosomal mutation sites of the quinolone resistance-determining region, which mediated quinolone resistance. The c749 genome comprised a single plasmid, pRJ749, with a multiple resistance region, including three plasmid-mediated quinolone resistance (PMQR) genes (aac (6′)-Ib-cr, qnrS2, and oqxAB) and ten acquired resistance genes. One of the genes, qnrS2, was shown for the first time to be flanked by two IS26s. Three IS26-mediated circular molecules carrying the PMQR genes were detected. Conclusions:We revealed the coexistence of three PMQR genes on a multiple resistance plasmid and a new surrounding genetic structure of qnrS2 flanked by IS26 elements. IS26 plays an important role in horizontal spread of quinolone resistance.

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“…Additionally, CRE were also detected in chickens and pigs at slaughterhouses (4). Data from the China Antimicrobial Surveillance Network (CHINET) revealed that the rate of carbapenem resistance in K. pneumoniae increased from 9.3% in 2011 to 20.9% in 2017, whereas in Escherichia coli, the rate was maintained at 1.0% to 1.9% over this period (10). Thus, it seemed that CRE detected in retail meat samples might mainly be attributable to contamination from livestock during slaughter but not from human activity and hospital waste.…”

mentioning

confidence: 99%

Rapid Increase in Carbapenemase-Producing Enterobacteriaceae in Retail Meat Driven by the Spread of the bla _NDM-5 -Carrying IncX3 Plasmid in China from 2016 to 2018

Zhang

Huang

et al. 2019

Antimicrob Agents Chemother

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The presence and molecular characteristics of carbapenemase-producing Enterobacteriaceae (CPE) among meat products in China were investigated. A total of 110 carbapenem-resistant Enterobacteriaceae (CRE) isolates, including 94 Escherichia coli and 10 Klebsiella pneumoniae isolates, were identified from 105 of 794 (13.2%) samples. The positive rates markedly increased from 2016 (9.4%) to 2018 (22.2%). Only bla NDM genes were detected; 79.1% of bla NDM genes were carried by IncX3 plasmids. Routine monitoring of carbapenemase-producing Enterobacteriaceae in the animal food supply is highly recommended.

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Current Status and Trends of Antibacterial Resistance in China

Cited by 250 publications

References 8 publications

Sonobactericide: An Emerging Treatment Strategy for Bacterial Infections

Sonobactericide: An Emerging Treatment Strategy for Bacterial Infections

Emerging coexistence of three PMQR genes on a multiple resistance plasmid with a new surrounding genetic structure of qnrS2 in E. coli in China

Rapid Increase in Carbapenemase-Producing Enterobacteriaceae in Retail Meat Driven by the Spread of the bla _NDM-5 -Carrying IncX3 Plasmid in China from 2016 to 2018

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Current Status and Trends of Antibacterial Resistance in China

Cited by 250 publications

References 8 publications

Sonobactericide: An Emerging Treatment Strategy for Bacterial Infections

Sonobactericide: An Emerging Treatment Strategy for Bacterial Infections

Emerging coexistence of three PMQR genes on a multiple resistance plasmid with a new surrounding genetic structure of qnrS2 in E. coli in China

Rapid Increase in Carbapenemase-Producing Enterobacteriaceae in Retail Meat Driven by the Spread of the bla NDM-5 -Carrying IncX3 Plasmid in China from 2016 to 2018

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Rapid Increase in Carbapenemase-Producing Enterobacteriaceae in Retail Meat Driven by the Spread of the bla _NDM-5 -Carrying IncX3 Plasmid in China from 2016 to 2018