Current status and prospects of MOFs in controlled delivery of Pt anticancer drugs

Abstract

Cancer has become the second leading reason of death in the world. Still, cancer therapy development is exceptionally challenging because the tumor microenvironment is very complex, and individual tumors are...

Construction of Fe-doped ZIF-8/DOX nanocomposites for ferroptosis strategy in the treatment of breast cancer

“…7 The intracellular ROS include superoxide ion (O 2 ˙ − ), hydrogen peroxide (H 2 O 2 ), and hydroxyl radicals ( · OH). 8,9 Having an important influence on the behavior of cancers and the stromal components of the tumor, ROS can regulate the development and survival of cancer cells. Thence, ROS can be both essential and lethal to tumor cells.…”

A 3D paddle-wheel type Cu(ii)-based MOF with pcu topology as an efficient photocatalyst for antibiotics photodegradation

“…Metal–organic frameworks (MOFs) are a peculiar sub-class of coordination polymers that possess three-dimensional frameworks constituted by metal ions and polyfunctional organic ligands. 1–6 This assorted class of materials has received considerable attention due to their remarkable features such as a high surface area and tunable porosity, and are used in gas storage, catalysis, sensing, and drug delivery. 1–6 Nowadays, one of the main areas of research is the design and development of MOFs that can be employed as photocatalysts for the photodegradation of a variety of aquatic pollutants such as dyes, antibiotics etc.…”

“…1–6 This assorted class of materials has received considerable attention due to their remarkable features such as a high surface area and tunable porosity, and are used in gas storage, catalysis, sensing, and drug delivery. 1–6 Nowadays, one of the main areas of research is the design and development of MOFs that can be employed as photocatalysts for the photodegradation of a variety of aquatic pollutants such as dyes, antibiotics etc. 7,8 This is due to the fact that photocatalysis is a technique that is based on the conversion of light energy into chemical energy, and is both economical and ecologically beneficial.…”

Current status of Fe-based MOFs in biomedical applications

“…22–27 MOFs have been extensively studied because of their remarkable properties like flexible framework, large effective external surface, controllable size distribution, and good biocompatibility. 28–32 Thus, some MOFs are biomedically favorable for drug delivery and cancer therapy. 33–35…”