Current status and molecular biology of human papillomavirus‐independent gastric‐type adenocarcinoma of the cervix

Abstract

This article reviews the findings of clinical studies on gastric-type adenocarcinoma of the cervix to date, outline the molecular biological features identified in recent studies, and discusses the future therapeutic strategies. Gastric-type adenocarcinoma of the cervix is a new classification in the World Health Organization 2014 classification. The World Health Organization 2020 classification further divides cervical tumors into two categories: human papillomavirus-associated and human papillomavirus-independent. Thus, gastric-type adenocarcinoma of the cervix is now classified as a human papillomavirus-independent gastric type. Clinical studies have reported that gastric adenocarcinoma of the cervix is refractory to conventional chemotherapy and radiotherapy, and it is desirable to elucidate its molecular biological mechanism. A series of gene mutations characteristic to the gastric-type adenocarcinoma of the cervix encourage the development of future treatment strategies. K E Y W O R D Sgene mutation, HPV-independent gastric-type adenocarcinoma of the cervix, molecular biological features

Gastric-type adenocarcinoma of the uterine cervix: clinical features and future directions

“…GAS has a wide range of atypia, from minimal to marked. The tumour cells form glands and solid areas, but papillary, trabecular or single-cell patterns can be present ( 20 ). The glands deeply infiltrate stroma, including a desmoplastic response, and lymphovascular invasion is also common.…”