Current status and future prospects of drug eluting stents for restenosis / Sadašnjost i budućnost stentova za restenozu koji otpuštaju lijekove

Patel, Maulik J.; Patel, Sanjay; Patel, Nidhi; Patel, Nachiket

doi:10.2478/v10007-012-0036-8

Cited by 15 publications

(3 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The IgakiTamai scaffold had a self-expanding zigzag helical coil design, where the self-expansion of this scaffold was assisted by balloon-expansion. The obtained results of this first study in humans demonstrated a low restenosis rate and a re-intervention rate of 10.5 % at 6 months [98]. The first clinically investigated fully absorbable DES is the bioresorbable vascular scaffold (BVS) by Abbott Vascular (USA).…”

Section: Polymers For Stent Platformsmentioning

confidence: 93%

See 1 more Smart Citation

Polymers in Cardiology

Sternberg¹,

Busch

Petersen

2014

Advanced Polymers in Medicine

View full text Add to dashboard Cite

Polymers have found widespread applications in cardiology, in particular in coronary vascular intervention as stent platforms, coating matrices for drug-eluting stents (DES) and drug-coated balloons (DCB) and for transcatheter valve therapy. Besides permanent polymers, biodegradable polymers came in focus of current research and development for medical applications, as they degrade once their function is fulfilled, which might efficiently reduce observed hypersensitivity reactions. After reviewing polymers used for cardiovascular applications, the book chapter deals with possible surface modification reactions of the polymers including the provision with a local drug delivery function and/ or biofunctionalization in order to selectively control cell-implant interactions. These functionalizations can be furthermore designed to enhance bio-and hemocompatibility, which is of special interest for cardiovascular implants and devices. A general discussion of bio-and hemo-compatibility of polymers for cardiovascular applications and corresponding evaluation methods is additionally given. With our own published data, we finally highlight exemplary polymer applications in cardiology as polymer-based biodegradable stent platforms, biodegradable polymeric coatings for DES and hydrogel-based coatings for DCB. Moreover, developed biofunctionalization strategies of polymers are discussed with regard to their application in cardiology.

show abstract

Section: Polymers For Stent Platformsmentioning

confidence: 93%

“…As first Tamai et al [98] reported their clinical experiences with an absorbable coronary polymer scaffold made from PLLA, the Igaki-Tamai scaffold. The IgakiTamai scaffold had a self-expanding zigzag helical coil design, where the self-expansion of this scaffold was assisted by balloon-expansion.…”

Section: Polymers For Stent Platformsmentioning

confidence: 99%

Polymers in Cardiology

Sternberg¹,

Busch

Petersen

2014

Advanced Polymers in Medicine

View full text Add to dashboard Cite

show abstract

“…Recently, biodegradable polymers (such as PLA and polylactide-co-glycolide – PLGA), and polymer-free DES were extensively studied to optimize their biocompatibility. 58 …”

Section: Instent Restenosismentioning

confidence: 99%

Some Perspectives on Hypersensitivity to Coronary Stents

Chioncel¹,

Andrei²,

Brezeanu³

et al. 2021

IJGM

View full text Add to dashboard Cite

The development of coronary stents has represented a revolution in the treatment of coronary heart disease. Beyond their many advantages, stents also have their limitations and complications. Allergic reactions to coronary stents are more common than acknowledged. These stented patients are exposed to foreign substances inserted in direct contact with the coronary intima. Hypersensitivity to stent components and drugs prescribed after stent insertion together with any environmental exposure seem to contribute to these adverse reactions. Patients can present to the hospital with a wide range of symptoms and multiple complications, the most important ones being instent restenosis and stent thrombosis. Although not very common (and not always easy to identify), allergic reactions after coronary or peripheral stents should be taken into account. Careful selection of patients (for elective stent implantation) depending on the propensity to allergies, although hard to achieve, represents a key factor in reducing the number of these complications.

show abstract

Endovascular Metal Devices for the Treatment of Cerebrovascular Diseases

Zhang

et al. 2018

Advanced Materials

View full text Add to dashboard Cite

Cerebrovascular disease involves various medical disorders that obstruct brain blood vessels or deteriorate cerebral circulation, resulting in ischemic or hemorrhagic stroke. Platinum coils with or without biological modification have become routine embolization devices in the cerebral aneurysm sac to reduce the risk of bleeding. Many intracranial stents, flow diverters and stent retrievers have been invented with uniquely designed structures. To accelerate the translation of these devices into clinical usage, an indepth understanding of the mechanical and material performance of these metal-based devices is critical. However, considering the more distal location and tortuous anatomic characteristics of cerebral arteries, present devices still risk failing to arrive at target lesions. Consequently, more flexible endovascular devices and novel designs are under urgent demand to overcome the deficiencies of existing devices. Herein, we discuss the pros and cons of the current structural designs when these devices are applied to the treatment of diseases ranging broadly from hemorrhages to ischemic strokes, in order to encourage further development of such kind of devices and investigation of their use in the clinic. Moreover, novel biodegradable materials and drug elution techniques, and the design, safety and efficacy of personalized devices for further clinical applications in cerebral vasculature are discussed.

show abstract

Current status and future prospects of drug eluting stents for restenosis / Sadašnjost i budućnost stentova za restenozu koji otpuštaju lijekove

Cited by 15 publications

References 35 publications

Polymers in Cardiology

Polymers in Cardiology

Some Perspectives on Hypersensitivity to Coronary Stents

Endovascular Metal Devices for the Treatment of Cerebrovascular Diseases

Contact Info

Product

Resources

About