Current Status and Future Perspectives of Sonodynamic Therapy and Sonosensitiers

Liu, Xinghan; Li, Sha; Wang, Meng; Dai, Zhijun

doi:10.7314/apjcp.2015.16.11.4489

Cited by 12 publications

(5 citation statements)

References 35 publications

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“…Similar to PDT, SDT also requires three basic conditions, including ultrasound, O 2 , and sonosensitizers. In the presence of ultrasound and O 2 , the generation of ROS through the stimulated sonosensitizer and the ultrasound-activated cavitation effects can induce apoptosis, necrosis, and autophagy, thus ultimately contributing to tumor destruction 23 , 24 , 25 . Acoustic cavitation can be divided into inertial cavitation and non-inertial cavitation, which is mainly composed of three stages including nucleation, growth, and collapse of bubbles 9 , 26 .…”

Section: Mechanisms Of Spdtmentioning

confidence: 99%

Recent progress in sono-photodynamic cancer therapy: From developed new sensitizers to nanotechnology-based efficacy-enhancing strategies

Zheng

et al. 2021

Acta Pharmaceutica Sinica B

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Many sensitizers have not only photodynamic effects, but also sonodynamic effects. Therefore, the combination of sonodynamic therapy (SDT) and photodynamic therapy (PDT) using sensitizers for sono-photodynamic therapy (SPDT) provides alternative opportunities for clinical cancer therapy. Although significant advances have been made in synthesizing new sensitizers for SPDT, few of them are successfully applied in clinical settings. The anti-tumor effects of the sensitizers are restricted by the lack of tumor-targeting specificity, incapability in deep intratumoral delivery, and the deteriorating tumor microenvironment. The application of nanotechnology-based drug delivery systems (NDDSs) can solve the above shortcomings, thereby improving the SPDT efficacy. This review summarizes various sensitizers as sono/photosensitizers that can be further used in SPDT, and describes different strategies for enhancing tumor treatment by NDDSs, such as overcoming biological barriers, improving tumor-targeted delivery and intratumoral delivery, providing stimuli-responsive controlled-release characteristics, stimulating anti-tumor immunity, increasing oxygen supply, employing different therapeutic modalities, and combining diagnosis and treatment. The challenges and prospects for further development of intelligent sensitizers and translational NDDSs for SPDT are also discussed.

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Section: Mechanisms Of Spdtmentioning

confidence: 99%

Recent progress in sono-photodynamic cancer therapy: From developed new sensitizers to nanotechnology-based efficacy-enhancing strategies

Zheng

et al. 2021

Acta Pharmaceutica Sinica B

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“…The first one assumes that the reactive oxygen species—singlet oxygen—is the active substance induced in the process of sonodynamic reactions, leading to cellular death [32].…”

Section: Sonodynamic Therapy Of Cancers: Definitions and Mechanismsmentioning

confidence: 99%

Sonodynamic Therapy for Gliomas. Perspectives and Prospects of Selective Sonosensitization of Glioma Cells

Bilmin

Kujawska

Grieb

2019

Cells

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Malignant glial tumors (gliomas) are the second (after cerebral stroke) cause of death from diseases of the central nervous system. The current routine therapy, involving a combination of tumor resection, radio-, and chemo-therapy, only modestly improves survival. Sonodynamic therapy (SDT) has been broadly defined as a synergistic effect of sonication applied in combination with substances referred to as “sonosensitizers”. The current review focuses on the possibility of the use of tumor-seeking sonosensitizers, in particular 5-aminolevulinic acid, to control recurring gliomas. In this application, SDT employs a principle similar to that of the more widely-known photodynamic therapy of superficially located cancers, the difference being the use of ultrasound instead of light to deliver the energy necessary to eliminate the sensitized malignant cells. The ability of ultrasound to penetrate brain tissues makes it possible to reach deeply localized intracranial tumors such as gliomas. The major potential advantage of this variant of SDT is its relative non-invasiveness and possibility of repeated application. Until now, there have been no clinical data regarding the efficacy and safety of such treatment for malignant gliomas, but the preclinical data are encouraging.

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“…In this regard, the increase in temperature and oxygenation promotes the effectiveness of chemotherapy [45]. In oncology, LIPUS treatment has been studied for several therapeutic uses [80]: (a) Sonodynamic Therapy (SDT): combination of LIPUS and sonosensitizers to affect cancer cells [81,82,83]; (b) ultrasound-mediated chemotherapy: combination of LIPUS and chemotherapeutic molecules that increase their activity in cancer therapy [84,85,86]; (c) sonoporation: technique used both to affect cells directly and for gene delivery or transfection [87,88] and (d) molecular effects on cancer cells [81,82,83,89,90].…”

Section: Biophysical Therapies In Oncologymentioning

confidence: 99%

Adjuvant Biophysical Therapies in Osteosarcoma

Carina

Costa

Sartori

et al. 2019

Cancers

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Osteosarcoma (OS) is a primary bone sarcoma, manifesting as osteogenesis by malignant cells. Nowadays, patients’ quality of life has been improved, however continuing high rates of limb amputation, pulmonary metastasis and drug toxicity, remain unresolved issues. Thus, effective osteosarcoma therapies are still required. Recently, the potentialities of biophysical treatments in osteosarcoma have been evaluated and seem to offer a promising future, thanks in this field as they are less invasive. Several approaches have been investigated such as hyperthermia (HT), high intensity focused ultrasound (HIFU), low intensity pulsed ultrasound (LIPUS) and sono- and photodynamic therapies (SDT, PDT). This review aims to summarize in vitro and in vivo studies and clinical trials employing biophysical stimuli in osteosarcoma treatment. The findings underscore how the technological development of biophysical therapies might represent an adjuvant role and, in some cases, alternative role to the surgery, radio and chemotherapy treatment of OS. Among them, the most promising are HIFU and HT, which are already employed in OS patient treatment, while LIPUS/SDT and PDT seem to be particularly interesting for their low toxicity.

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Current Status and Future Perspectives of Sonodynamic Therapy and Sonosensitiers

Cited by 12 publications

References 35 publications

Recent progress in sono-photodynamic cancer therapy: From developed new sensitizers to nanotechnology-based efficacy-enhancing strategies

Recent progress in sono-photodynamic cancer therapy: From developed new sensitizers to nanotechnology-based efficacy-enhancing strategies

Sonodynamic Therapy for Gliomas. Perspectives and Prospects of Selective Sonosensitization of Glioma Cells

Adjuvant Biophysical Therapies in Osteosarcoma

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