Current status and future developments in preparation and application of nonspherical polymer particles

Yu, Bing; Cong, Hailin; Peng, Qiaohong; Gu, Chuantao; Tang, Qi; Xu, Xiaodan; Tian, Chao; Zhai, Feng

doi:10.1016/j.cis.2018.04.010

Cited by 56 publications

(45 citation statements)

References 297 publications

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“…The main achievements concerned synthesis techniques deriving from phase separation of immiscible macromolecules and leading to anisotropic polymer particles …”

Section: Processes Based On Controlled Phase Separation Phenomenamentioning

confidence: 99%

“…The main achievements concerned synthesis techniques deriving from phase separation of immiscible macromolecules and leadingtoa nisotropic polymer particles. [10,14] The historical way was cleared in the 80s' when emulsion polymerization of organic monomers was experienced in the presence of cross-linked polymer seeds. The anisotropy arises from the immiscibility of the second stage polymer in crosslinked polymer networks,l eading to the formation of ap rotrusion on one side of the seed particle.…”

Section: Processes Based On Controlled Phase Separation Phenomenamentioning

confidence: 99%

“…We propose here an update by reviewing the most significant works published these last eight years. The reader has to refer to our previous review to embrace the full story and/or to read other excellent recent reviews written by others and addressing the field from other angles …”

Section: Introductionmentioning

confidence: 99%

“…The readerh as to refer to our previousr eview [4] to embrace the full story and/or to read other excellent recentr eviews written by others and addressing the field from other angles. [5][6][7][8][9][10][11][12][13]…”

Section: Introductionmentioning

confidence: 99%

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Synthesis of Colloidal Molecules: Recent Advances and Perspectives

Merindol

Duguet

Ravaine

2019

Chemistry An Asian Journal

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The synthesis and study of colloidal molecules, that is to say clusters of a small number of colloidal entities that resemble the configuration of atoms in molecules both in constituent size and angular arrangement to that of valence shell electron pair repulsion model‐related space‐filling geometries, are of continued and significant interest. The rapid development in this research area has attracted intense interest from researchers with diverse expertise, and numerous methods towards the synthesis of colloidal molecules have been reported. In this Minireview, we attempt to give an overview of these latest developments, classifying them in processes based on controlled phase separation phenomena, on controlled surface nucleation and growth, and on controlled clustering. We also discuss the potential use of colloidal molecules as building blocks to fabricate new hierarchically organized superstructures and functional materials.

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“…The main achievements concerned synthesis techniques deriving from phase separation of immiscible macromolecules and leading to anisotropic polymer particles …”

Section: Processes Based On Controlled Phase Separation Phenomenamentioning

confidence: 99%

Section: Processes Based On Controlled Phase Separation Phenomenamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Synthesis of Colloidal Molecules: Recent Advances and Perspectives

Merindol

Duguet

Ravaine

2019

Chemistry An Asian Journal

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“…Among all mentioned procedures, the masking method has received much attention for preparing Janus particles. 10 − 15 …”

Section: Introductionmentioning

confidence: 99%

Ultrasonic De-cross-linking of the pH- and Magneto-Responsive PHEMA/PMMA Microgel to Janus Nanoparticles: A New Synthesis Based on “Grafting from”/“Grafting to” Polymerization

2020

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Stimuli-responsive Janus nanoparticles (NPs) with a two-facial structure have been used widely in biomedical applications. Among several methods to prepare these NPs, surface-initiated atom transfer radical polymerization (SI-ATRP) has received much attention due to the precise deposition of polymers on the surface of the substrate. In this study, Janus nanoparticles with asymmetric surface chemistry were prepared through a masking method in three steps involving the covalent deposition of super paramagnetic iron oxide nanoparticles (SPIONs) on the cross-linked substrate based on methotrexate (MTX)-grafted poly(2-hydroxyethyl methacrylate) (CPM), surface functionalization of unreacted sites of immobilized SPIONs with 2-bromoisobutyryl bromide (BIBB) in order to prepare the macro-initiator (Br-Fe 3 O 4 -CPM), growing poly(methyl methacrylate) (PMMA) on the surface of the macro-initiator through the SI-ATRP method. Optical microscopy was utilized to monitor the successful modification of SPIONs. Poly(methyl methacrylate)-iron oxide-poly(2-hydroxyethyl methacrylate) (PMMA-Fe 3 O 4 -PHEMA) microgel was exposed to optimum ultrasound (US) waves to prepare the PMMA-Fe 3 O 4 -PHEMA nanoparticle. Transmission electron microscopy (TEM) was used to confirm the precise deposition of polymers and the Janus structure. The MTX release of US-synthesized Janus NPs was studied in PBS at pH values of 7.4 and 5.8. The release data were analyzed using the Excel add-in DDSolver program to evaluate the kinetics of the drug release process from the nanocarrier under different pH values.

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